Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 3
Submit an article Journal homepage
40
Views
14
CrossRef citations to date
0
Altmetric
Research Article

o-Nitroanilines as major metabolic products of anti-Trypanosoma cruzi 5-phenylethenylbenzofuroxans in microsomal and cytosolic fractions of rat hepatocytes and in whole parasitic cells

M. BoianiDepartamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
,
A. MerlinoDepartamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
,
A. GerpeDepartamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
,
W. PorcalDepartamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
,
F. CroceDepartamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
,
S. DepaulaArea Análisis Químicos, Polo Tecnológico, Facultad de Química, Universidad de la República, Pando, Uruguay
,
M.A. RodríguezArea Análisis Químicos, Polo Tecnológico, Facultad de Química, Universidad de la República, Pando, Uruguay
,
H. CerecettoDepartamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Montevideo, UruguayCorrespondence[email protected]
&
M. GonzálezDepartamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
 show all
Pages 236-248 | Received 13 Nov 2008, Accepted 15 Dec 2008, Published online: 01 Mar 2009

Citations (14)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Mercedes González & Hugo Cerecetto. (2011) Novel compounds to combat trypanosomatid infections: a medicinal chemical perspective. Expert Opinion on Therapeutic Patents 21:5, pages 699-715.
Read now

Articles from other publishers (13)

Elena Aguilera, Carina Sánchez, María Eugenia Cruces, Belén Dávila, Lucía Minini, Florencia Mosquillo, Leticia Pérez-Díaz, Elva Serna, Susana Torres, Alicia Schini, Luis Sanabria, Ninfa I. Vera de Bilbao, Gloria Yaluff, Flavio R. Zolessi, Luis Fabian Ceilas, Hugo Cerecetto & Guzmán Alvarez. (2022) Preclinical Studies and Drug Combination of Low-Cost Molecules for Chagas Disease. Pharmaceuticals 16:1, pages 20.
Crossref
Dipak B. Patil, Rocío Gámez‐Montaño, Mario Ordoñez, Melchor Solis‐Santos, J. Oscar C. Jiménez‐Halla & César R. Solorio‐Alvarado. (2022) Iodine(III)‐Mediated Electrophilic Chlorination and Catalytic Nitration of N ‐Tosyl Anilines . European Journal of Organic Chemistry 2022:47.
Crossref
Guzmán Alvarez, Lisa van Pul, Xavier Robert, Zoraima Artía, Ad C. van Nuenen, Mathieu Long, Natalia Sierra, Williams Porcal, Neeltje A. Kootstra & Christophe Guillon. (2022) Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo. BMC Pharmacology and Toxicology 23:1.
Crossref
Cintya Perdomo, Elena Aguilera, Ileana Corvo, Paula Faral-Tello, Elva Serna, Carlos Robello, Shane R. Wilkinson, Gloria Yaluff & Guzmán Alvarez. (2021) Preclinical Studies in Anti-Trypanosomatidae Drug Development. Pharmaceuticals 14:7, pages 644.
Crossref
Elena Aguilera, Cintya Perdomo, Alejandra Espindola, Ileana Corvo, Paula Faral-Tello, Carlos Robello, Elva Serna, Fátima Benítez, Rocío Riveros, Susana Torres, Ninfa I. Vera de Bilbao, Gloria Yaluff & Guzmán Alvarez. (2019) A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids. Molecules 24:20, pages 3800.
Crossref
Mauricio Cabrera, Stefani de Ovalle, Mariela Bollati-Fogolín, Fabiana Nascimento, Patrícia Corbelini, Fernanda Janarelli, Daniel Kawano, Vera Lucia Eifler-Lima, Mercedes González & Hugo Cerecetto. (2015) New hits as phase II enzymes inducers from a focused library with heteroatom–heteroatom and Michael-acceptor motives. Future Science OA 1:3.
Crossref
Guzmán Álvarez, Javier Varela, Eugenia Cruces, Marcelo Fernández, Martín Gabay, Sandra M. Leal, Patricia Escobar, Luis Sanabria, Elva Serna, Susana Torres, Susy J. Figueredo Thiel, Gloria Yaluff, Ninfa I. Vera de Bilbao, Hugo Cerecetto & Mercedes González. (2015) Identification of a New Amide-Containing Thiazole as a Drug Candidate for Treatment of Chagas' Disease. Antimicrobial Agents and Chemotherapy 59:3, pages 1398-1404.
Crossref
Guzmán Álvarez, Javier Varela, Pablo Márquez, Martín Gabay, Carmen Elena Arias Rivas, Karina Cuchilla, Gustavo A. Echeverría, Oscar E. Piro, Marlus Chorilli, Sandra M. Leal, Patricia Escobar, Elva Serna, Susana Torres, Gloria Yaluff, Ninfa I. Vera de Bilbao, Mercedes González & Hugo Cerecetto. (2014) Optimization of Antitrypanosomatid Agents: Identification of Nonmutagenic Drug Candidates with in Vivo Activity. Journal of Medicinal Chemistry 57:10, pages 3984-3999.
Crossref
Javier Varela, María L. Lavaggi, Mauricio Cabrera, Alejandra Rodríguez, Patricio Miño, Ximena Chiriboga, Hugo Cerecetto & Mercedes González. (2012) Bioactive-guided Identification of Labdane Diterpenoids from Aerial Parts of Aristeguietia glutinosa as anti- Trypanosoma cruzi agents . Natural Product Communications 7:9, pages 1934578X1200700.
Crossref
Mariana Boiani, Lucia Piacenza, Paola Hernández, Lucia Boiani, Hugo Cerecetto, Mercedes González & Ana Denicola. (2010) Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?. Biochemical Pharmacology 79:12, pages 1736-1745.
Crossref
Hugo Cerecetto & Mercedes González. (2010) Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase. Pharmaceuticals 3:4, pages 810-838.
Crossref
Diego Castro, Lucia Boiani, Diego Benitez, Paola Hernández, Alicia Merlino, Carmen Gil, Claudio Olea-Azar, Mercedes González, Hugo Cerecetto & Williams Porcal. (2009) Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies. European Journal of Medicinal Chemistry 44:12, pages 5055-5065.
Crossref
Mauricio Cabrera, María Laura Lavaggi, Paola Hernández, Alicia Merlino, Alejandra Gerpe, Williams Porcal, Mariana Boiani, Ana Ferreira, Antonio Monge, Adela López de Cerain, Mercedes González & Hugo Cerecetto. (2009) Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction. Toxicology Letters 190:2, pages 140-149.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.