Xenobiotica, Volume 39, Issue 3 (2009)

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Xenobiotica, Volume 39, Issue 3 (2009)

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Commentary

Article Commentary
Drug–drug interaction studies in preclinical species: should metabolite(s) kinetics be studied?
N. R. Srinivas
Pages: 193-196
Published online: 01 Mar 2009
AbstractforDrug–drug interaction studies in preclinical species: should metabolite(s) kinetics be studied? | Full Text | References | PDF (502.9 KB)
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Research Article

Article
2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton
E.M. Joshi, B.H. Heasley & T.L. Macdonald
Pages: 197-204
Published online: 01 Mar 2009
Abstractfor2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton | Full Text | References | PDF (977 KB)
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Article
Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells
S. Choi, B. Sainz Jr., P. Corcoran, S. Uprichard & H. Jeong
Pages: 205-217
Published online: 01 Mar 2009
AbstractforCharacterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells | Full Text | References | PDF (805.2 KB)
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Article
Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs
K. Hagihara, M. Kazui, H. Ikenaga, T. Nanba, K. Fusegawa, M. Takahashi, A. Kurihara, O. Okazaki, N. A Farid & T. Ikeda
Pages: 218-226
Published online: 01 Mar 2009
AbstractforComparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs | Full Text | References | PDF (798.4 KB)
  • 339 Views
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Article
Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding
C. Emoto, N. Murayama, A. Rostami-Hodjegan & H. Yamazaki
Pages: 227-235
Published online: 01 Mar 2009
AbstractforUtilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding | Full Text | References | PDF (881.5 KB)
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Article
o-Nitroanilines as major metabolic products of anti-Trypanosoma cruzi 5-phenylethenylbenzofuroxans in microsomal and cytosolic fractions of rat hepatocytes and in whole parasitic cells
M. Boiani, A. Merlino, A. Gerpe, W. Porcal, F. Croce, S. Depaula, M.A. Rodríguez, H. Cerecetto & M. González
Pages: 236-248
Published online: 01 Mar 2009
Abstractforo-Nitroanilines as major metabolic products of anti-Trypanosoma cruzi 5-phenylethenylbenzofuroxans in microsomal and cytosolic fractions of rat hepatocytes and in whole parasitic cells | Full Text | References | PDF (1.4 MB)
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Article
Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers
L. Fan, X.-Q. Mao, G.-Y. Tao, G. Wang, F. Jiang, Y. Chen, Q. Li, W. Zhang, H.-P. Lei, D.-L. Hu, Y.-F. Huang, D. Wang & H.-H. Zhou
Pages: 249-254
Published online: 01 Mar 2009
AbstractforEffect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers | Full Text | References | PDF (667.4 KB)
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Article
Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2′-benzoyloxycinnamaldehyde in rats
Kiho Lee, Byoung-Mog Kwon, Kangjeon Kim, Jekyung Ryu, Soo Jin Oh, Kye Sook Lee, Mu-Gil Kwon, Song-Kyu Park, Jong Soon Kang, Chang Woo Lee & Hwan Mook Kim
Pages: 255-265
Published online: 01 Mar 2009
AbstractforPlasma pharmacokinetics and metabolism of the antitumour drug candidate 2′-benzoyloxycinnamaldehyde in rats | Full Text | References | PDF (1.2 MB)
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Article
Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions
K. W. Ward, D. J. Coon, D. Magiera, S. Bhadresa, M. Struharik & M. S. Lawrence
Pages: 266-272
Published online: 01 Mar 2009
AbstractforExploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions | Full Text | References | PDF (739.1 KB)
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Article
Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit
S. X. Zhang, P. W. Yang, D. C. Zhang, W. Q. Dong, F. H. Zhang & Y. M. Sun
Pages: 273-281
Published online: 01 Mar 2009
AbstractforPharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit | Full Text | References | PDF (855.8 KB) | Supplemental
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Acknowledgements

Acknowledgements
Page: 282
Published online: 01 Mar 2009
CitationforAcknowledgements | Full Text | PDF (433.7 KB)
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