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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 4
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Research Article

Mechanism-based inhibition of CYP1A2 by antofloxacin, an 8-NH2 derivative of levofloxacin in rats

Q. ZhuKey Laboratory of Drug Metabolism and Pharmacokinetics
,
J. LiaoDepartment of Information Management and System, China Pharmaceutic University, Nanjing, P. R. China
,
L. XieKey Laboratory of Drug Metabolism and Pharmacokinetics
,
G. J. WangKey Laboratory of Drug Metabolism and Pharmacokinetics
&
X. D. LiuKey Laboratory of Drug Metabolism and PharmacokineticsCorrespondence[email protected]
Pages 293-301 | Received 22 Dec 2008, Accepted 22 Dec 2008, Published online: 01 Apr 2009

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J. Wang, Y. Xiao, Y. Lu, Z. Kang, M. Zhang, Y. Liu, J. Liang, M. Zhang & T. Li. (2011) Pharmacokinetics of antofloxacin hydrochloride in healthy male subjects after multiple intravenous dose administration. Xenobiotica 41:7, pages 561-566.
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Shu-Feng Zhou, Bo Wang, Li-Ping Yang & Jun-Ping Liu. (2010) Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metabolism Reviews 42:2, pages 268-354.
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J. Wang, Y. Xiao, Y. Lu, Z. Kang, M. Zhang, Y. Liu, J. Liang, M. Zhang & T. Li. (2010) Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers. Xenobiotica 40:5, pages 344-349.
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Sandra Doß, Corinne Blessing, Katharina Haller, Georg Richter & Martin Sauer. (2022) Influence of Antibiotics on Functionality and Viability of Liver Cells In Vitro. Current Issues in Molecular Biology 44:10, pages 4639-4657.
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Ying Zhang, Cunbin Du, Yang Cong, Yi Xue, Bin Qiao, Tingting Ye & Mingliang Wang. (2019) Solubility Increment and Thermodynamic Analysis of Bioactive Antofloxacin Hydrochloride in Aqueous ChCl/PTS Deep Eutectic Solvent and Cosolvent Mixtures. Journal of Chemical & Engineering Data 64:12, pages 5748-5754.
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Xin-Yue JING, Yun-Ru PENG, Xin-Min WANG & Jin-Ao DUAN. (2015) Effects of Ziziphus jujuba fruit extracts on cytochrome P450 (CYP1A2) activity in rats. Chinese Journal of Natural Medicines 13:8, pages 588-594.
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Na Gao, Bing Qi, Fang-jun Liu, Yan Fang, Jun Zhou, Lin-jing Jia & Hai-ling Qiao. (2014) Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS ONE 9:2, pages e89752.
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Ling-ling Jia, Ze-yu Zhong, Feng Li, Zhao-li Ling, Yang Chen, Wei-man Zhao, Ying Li, Shu-wen Jiang, Ping Xu, Yang Yang, Meng-yue Hu, Li Liu & Xiao-dong Liu. (2014) The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats. Journal of Pharmacological Sciences 124:4, pages 468-479.
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Ping Wang, Xian Pan, Guanming Chen, Jia Li, Li Liu, Xiaodong Liu, Shi Jin, Lin Xie & Guangji Wang. (2012) Increased Exposure of Vitamin A by Chrysanthemum morifolium Ramat Extract in Rat Was Not via Induction of CYP1A1, CYP1A2, and CYP2B1. Journal of Food Science 77:6, pages H121-H127.
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Li Liu, Xian Pan, Hai-yan Liu, Xiao-dong Liu, Hui-wen Yang, Lin Xie, Jun-lin Cheng, Hong-wei Fan & Da-wei Xiao. (2011) Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta Pharmacologica Sinica 32:10, pages 1285-1293.
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Xian Pan, Ping Wang, Nan Hu, Li Liu, Xiaodong Liu, Lin Xie & Guangji Wang. (2011) A Physiologically Based Pharmacokinetic Model Characterizing Mechanism-based Inhibition of CYP1A2 for Predicting Theophylline/Antofloxacin Interaction in both Rats and Humans. Drug Metabolism and Pharmacokinetics 26:4, pages 387-398.
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Liwei Hu, Wen Xu, Xi Zhang, Juan Su, Xinru Liu, Haiyun Li & Weidong Zhang. (2010) In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. Journal of Pharmacy and Pharmacology 62:5, pages 658-662.
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Shu-Feng Zhou, Li-Ping Yang, Zhi-Wei Zhou, Ya-He Liu & Eli Chan. (2009) Insights into the Substrate Specificity, Inhibitors, Regulation, and Polymorphisms and the Clinical Impact of Human Cytochrome P450 1A2. The AAPS Journal 11:3, pages 481-494.
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