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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 10
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Research Article

Metabolism-related liabilities of a potent histone deacetylase (HDAC) inhibitor and relevance of the route of administration on its metabolic fate

M. FonsiDepartments of DMPK, IRBM, Merck Research Laboratories, Rome, ItalyCorrespondence[email protected]
,
F. FioreDepartments of Pharmacology, IRBM, Merck Research Laboratories, Rome, Italy
,
P. JonesDepartments of Chemistry, IRBM, Merck Research Laboratories, Rome, Italy
,
O. KinzelDepartments of Chemistry, IRBM, Merck Research Laboratories, Rome, Italy
,
R. LauferDepartments of Pharmacology, IRBM, Merck Research Laboratories, Rome, Italy
,
M. RowleyDepartments of Chemistry, IRBM, Merck Research Laboratories, Rome, Italy
&
E. MonteagudoDepartments of DMPK, IRBM, Merck Research Laboratories, Rome, Italy
 show all
Pages 722-737 | Received 14 Apr 2009, Accepted 01 Jun 2009, Published online: 01 Jul 2009

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Nadine Martinet & Philippe Bertrand. (2011) Interpreting clinical assays for histone deacetylase inhibitors. Cancer Management and Research 3, pages 117-141.
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Matthew W Lawless, Kenneth J O'Byrne & Steven G Gray. (2010) Targeting oxidative stress in cancer. Expert Opinion on Therapeutic Targets 14:11, pages 1225-1245.
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Raman Preet Kaur, Prabhsimran Kaur & Anjana Munshi. 2022. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1639 1655 .
Raman Preet Kaur, Prabhsimran Kaur & Anjana Munshi. 2020. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1 18 .
Alina Ciammaichella, Federica Ferrigno, Andreina Basta, Melania D'Amico, Ilaria Biancofiore, Valentina Nardi, Simona Ponzi, Rita Graziani, Nadia Gennari, Maria Vittoria Orsale, Ivan Fini, Giacomo Paonessa, Vincenzo Summa, Steven Harper & Jesus M. Ontoria. (2020) Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT. Bioorganic & Medicinal Chemistry Letters 30:12, pages 127207.
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Federica Ferrigno, Ilaria Biancofiore, Savina Malancona, Simona Ponzi, Giacomo Paonessa, Rita Graziani, Alberto Bresciani, Nadia Gennari, Annalise Di Marco, Marcel Kaiser, Vincenzo Summa, Steven Harper & Jesus M. Ontoria. (2018) Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro. Bioorganic & Medicinal Chemistry Letters 28:23-24, pages 3689-3692.
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