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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 9
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Xenobiotic Transporters

Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions

Ryota KikuchiDepartment of Drug Metabolism and Pharmacokinetics, AbbVie Inc, North Chicago, IL, USACorrespondence[email protected]
,
Vincent C. PeterkinDepartment of Drug Metabolism and Pharmacokinetics, AbbVie Inc, North Chicago, IL, USA
,
William J. ChiouDepartment of Drug Metabolism and Pharmacokinetics, AbbVie Inc, North Chicago, IL, USA
,
Sonia M. de MoraisDepartment of Drug Metabolism and Pharmacokinetics, AbbVie Inc, North Chicago, IL, USA
&
Daniel A. J. BowDepartment of Drug Metabolism and Pharmacokinetics, AbbVie Inc, North Chicago, IL, USA
Pages 825-832 | Received 23 Jun 2016, Accepted 03 Sep 2016, Published online: 03 Oct 2016

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Julia Annette Schulz, David M. Stresser & John Cory Kalvass. (2023) Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review. Drug Metabolism Reviews 55:3, pages 205-238.
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Articles from other publishers (9)

A.D. Rodrigues. (2022) Reimagining the Framework Supporting the Static Analysis of Transporter Drug Interaction Risk; Integrated Use of Biomarkers to Generate Pan‐Transporter Inhibition Signatures . Clinical Pharmacology & Therapeutics 113:5, pages 986-1002.
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Srinivasan Krishnan, Diane Ramsden, Douglas Ferguson, Simone H. Stahl, Joanne Wang, Dermot F. McGinnity & Niresh Hariparsad. (2022) Challenges and Opportunities for Improved Drug–Drug Interaction Predictions for Renal OCT2 and MATE1/2‐K Transporters. Clinical Pharmacology & Therapeutics 112:3, pages 562-572.
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Eleanor Jing Yi Cheong, Daniel Zhi Wei Ng, Sheng Yuan Chin, Ziteng Wang & Eric Chun Yong Chan. (2022) Application of a physiologically based pharmacokinetic model of rivaroxaban to prospective simulations of drug–drug–disease interactions with protein kinase inhibitors in cancer‐associated venous thromboembolism. British Journal of Clinical Pharmacology 88:5, pages 2267-2283.
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Takeshi Miyake, Emi Kimoto, Lina Luo, Sumathy Mathialagan, Lauren M. Horlbogen, Ragu Ramanathan, Linda S. Wood, Jillian G. Johnson, Vu H. Le, Manoli Vourvahis, A. David Rodrigues, Chieko Muto, Kenichi Furihata, Yuichi Sugiyama & Hiroyuki Kusuhara. (2020) Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein‐Mediated Drug‐Drug Interactions in Healthy Volunteers. Clinical Pharmacology & Therapeutics 109:2, pages 507-516.
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Hari V. Kalluri, Ryota Kikuchi, Sheryl Coppola, Jeffrey Schmidt, Mohamed‐Eslam F. Mohamed, Daniel A.J. Bow & Ahmed H. Salem. (2020) Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study. Clinical and Translational Science 14:1, pages 373-381.
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Ruhul Kayesh, Taleah Farasyn, Alexandra Crowe, Qiang Liu, Sonia Pahwa, Khondoker Alam, Sibylle Neuhoff, Oliver Hatley, Kai Ding & Wei Yue. (2021) Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interaction Potential of Vemurafenib Using R-Value and Physiologically-Based Pharmacokinetic Models. Journal of Pharmaceutical Sciences 110:1, pages 314-324.
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Shunji Imai, Toshiki Arai, Tetsuhiro Yamada & Makoto Niwa. (2020) Improved In Vitro-In Vivo Correlation by Using the Unbound-Fraction-Adjusted IC50 for Breast Cancer Resistance Protein Inhibition. Pharmaceutical Research 37:12.
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Ryota Kikuchi, William J. Chiou, Miriam A. Kasai, Sonia M. de Morais & Daniel A.J. Bow. (2019) No Inhibition of MATE1/2K-Mediated Renal Creatinine Secretion Predicted With Ritonavir or Cobicistat. Journal of Pharmaceutical Sciences 108:9, pages 3118-3123.
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Matthew P. Kosloski, Daniel A.J. Bow, Ryota Kikuchi, Haoyu Wang, Elaine J. Kim, Kennan Marsh, Federico Mensa, Jens Kort & Wei Liu. (2019) Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir. Journal of Pharmacology and Experimental Therapeutics 370:2, pages 278-287.
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