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Xenobiotica
the fate of foreign compounds in biological systems
Volume 47, 2017 - Issue 12
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Clinical Pharmacokinetics and Metabolism

Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration

Justine L. LamDepartment of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc, San Diego, CA, USA, Correspondence[email protected]
,
Alfin VazDepartment of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc, Groton, CT, USA,
,
Brian HeeDepartment of Clinical Pharmacology, Pfizer Inc, San Diego, CA, USA, and
,
Yali LiangDepartment of Clinical Pharmacology, Pfizer Inc, Groton, CT, USA
,
Xin YangDepartment of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc, Groton, CT, USA,
&
M. Naveed ShaikDepartment of Clinical Pharmacology, Pfizer Inc, San Diego, CA, USA, and
Pages 1064-1076 | Received 13 Sep 2016, Accepted 12 Nov 2016, Published online: 03 Jan 2017

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Shahid Zaman, Hafiza Sana Arbab Yaqoob, Asad Ullah & Mariam Sheikh. (2023) QSPR Analysis of Some Novel Drugs Used in Blood Cancer Treatment Via Degree Based Topological Indices and Regression Models. Polycyclic Aromatic Compounds 0:0, pages 1-17.
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Luke K. Fostvedt, Naveed Shaik, Giovanni Martinelli, Andrew J. Wagner & Ana Ruiz-Garcia. (2021) Exposure–response modeling of the effect of glasdegib on cardiac repolarization in patients with cancer. Expert Review of Clinical Pharmacology 14:7, pages 927-935.
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Shawn M Sarkaria & Mark L Heaney. (2021) Glasdegib in newly diagnosed acute myeloid leukemia. Expert Review of Anticancer Therapy 21:6, pages 573-581.
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Jorge E. Cortes, Anna Candoni, Richard E. Clark, Brian Leber, Pau Montesinos, Paresh Vyas, Amer M. Zeidan & Michael Heuser. (2020) Selection and management of older patients with acute myeloid leukemia treated with glasdegib plus low-dose cytarabine: expert panel review. Leukemia & Lymphoma 61:14, pages 3287-3305.
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Xavier Thomas & Maël Heiblig. (2020) An evaluation of glasdegib for the treatment of acute myelogenous leukemia. Expert Opinion on Pharmacotherapy 21:5, pages 523-530.
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Articles from other publishers (16)

Ernesto Callegari, Susanna Tse, Angela C. Doran, Theunis C. Goosen & Naveed Shaik. (2023) Physiologically Based Pharmacokinetic Modeling of the Drug–Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical Study. The Journal of Clinical Pharmacology.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
Zifan Feng, Shanshan Zhu, Wenrui Li, Maojun Yao, Hualong Song & Ru-Bing Wang. (2022) Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy. European Journal of Medicinal Chemistry 244, pages 114867.
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Cyril Fersing & Fanny Mathias. (2022) Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors. Acta Pharmaceutica 72:1, pages 9-34.
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Joanna C. Masters, Robert R. LaBadie, Joanne Salageanu, Jerry Li & Naveed Shaik. (2020) Pharmacokinetics and Safety of Glasdegib in Participants With Moderate/Severe Hepatic Impairment: A Phase I, Single‐Dose, Matched Case‐Control Study. Clinical Pharmacology in Drug Development 10:7, pages 707-717.
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Ana Ruiz‐Garcia, Naveed Shaik, Swan Lin, Catriona Jamieson, Michael Heuser & Geoffrey Chan. (2020) Evaluation of the Relationship of Glasdegib Exposure and Safety End Points in Patients With Refractory Solid Tumors and Hematologic Malignancies. The Journal of Clinical Pharmacology 61:3, pages 349-359.
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Naveed Shaik, Robert R. LaBadie, Brian Hee & Geoffrey Chan. (2021) Evaluation of the impact of renal impairment on the pharmacokinetics of glasdegib in otherwise healthy volunteers. Cancer Chemotherapy and Pharmacology 87:2, pages 241-250.
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Swan Lin, Naveed Shaik, Giovanni Martinelli, Andrew J. Wagner, Jorge Cortes & Ana Ruiz‐Garcia. (2019) Population Pharmacokinetics of Glasdegib in Patients With Advanced Hematologic Malignancies and Solid Tumors. The Journal of Clinical Pharmacology 60:5, pages 605-616.
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Amit S. Kalgutkar & James P. Driscoll. (2020) Is there enough evidence to classify cycloalkyl amine substituents as structural alerts?. Biochemical Pharmacology 174, pages 113796.
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Anna Wolska-Washer & Tadeusz Robak. (2019) Glasdegib in the treatment of acute myeloid leukemia. Future Oncology 15:28, pages 3219-3232.
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Naveed Shaik, Brian Hee, Yali Liang & Robert Roland LaBadie. (2019) Absolute Oral Bioavailability of Glasdegib (PF‐04449913), a Smoothened Inhibitor, in Randomized Healthy Volunteers. Clinical Pharmacology in Drug Development 8:7, pages 895-902.
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Jorge E. Cortes, Ralf Gutzmer, Mark W. Kieran & James A. Solomon. (2019) Hedgehog signaling inhibitors in solid and hematological cancers. Cancer Treatment Reviews 76, pages 41-50.
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Naveed Shaik, Brian Hee, Hua Wei & Robert R. LaBadie. (2018) Evaluation of the effects of formulation, food, or a proton-pump inhibitor on the pharmacokinetics of glasdegib (PF-04449913) in healthy volunteers: a randomized phase I study. Cancer Chemotherapy and Pharmacology 83:3, pages 463-472.
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Sheridan M. Hoy. (2019) Glasdegib: First Global Approval. Drugs 79:2, pages 207-213.
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Richard L. Carpenter & Haimanti Ray. (2019) Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer. Drug Safety 42:2, pages 263-279.
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M. Naveed Shaik, Brian Hee, Hua Wei & Robert R. LaBadie. (2018) Evaluation of the effect of rifampin on the pharmacokinetics of the Smoothened inhibitor glasdegib in healthy volunteers. British Journal of Clinical Pharmacology 84:6, pages 1346-1353.
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