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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 8
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General Xenobiochemistry

Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes

Shinji IwasakiDrug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd, Cambridge, MA, USA and Correspondence[email protected]
,
Hideki HirabayashiDrug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd, Fujisawa, Japan
&
Nobuyuki AmanoDrug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd, Fujisawa, Japan
Pages 770-780 | Received 25 Jun 2017, Accepted 20 Aug 2017, Published online: 04 Sep 2017

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Shinji Iwasaki, Yohei Kosugi, Andy Z.X. Zhu, Sayaka Nakagawa, Noriyasu Sano, Miyuki Funami, Mai Kosaka, Atsutoshi Furuta, Hideki Hirabayashi & Nobuyuki Amano. (2019) Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach. Xenobiotica 49:11, pages 1251-1259.
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Articles from other publishers (2)

Yajuan Bi, Xue Wang, Hui Ding, Feng He, Lifeng Han & Youcai Zhang. (2022) Transporter-mediated Natural Product-Drug Interactions. Planta Medica 89:02, pages 119-133.
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Malavika Deodhar, Sweilem B. Al Rihani, Lucy Darakjian, Jacques Turgeon & Veronique Michaud. (2021) Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition. Pharmaceutics 13:2, pages 148.
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