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Xenobiotica
the fate of foreign compounds in biological systems
Volume 48, 2018 - Issue 8
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General Xenobiochemistry

Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes

Shinji IwasakiDrug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd, Cambridge, MA, USA and Correspondence[email protected]
,
Hideki HirabayashiDrug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd, Fujisawa, Japan
&
Nobuyuki AmanoDrug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co., Ltd, Fujisawa, Japan
Pages 770-780 | Received 25 Jun 2017, Accepted 20 Aug 2017, Published online: 04 Sep 2017

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