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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 2
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Clinical Pharmacokinetics and metabolism

Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans

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Pages 200-210 | Received 15 Dec 2017, Accepted 05 Jan 2018, Published online: 22 Jan 2018

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Daniel R Reed, Ramey Z Elsarrag, Amy L Morris & Michael K Keng. (2019) Enasidenib in acute myeloid leukemia: clinical development and perspectives on treatment. Cancer Management and Research 11, pages 8073-8080.
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Yiming Cheng, Xiaomin Wang, Atalanta Ghosh, Jie Pu, Leonidas N Carayannopoulos & Yan Li. (2024) Assessment of CYP‐Mediated Drug Interactions for Enasidenib Based on a Cocktail Study in Patients with Relapse or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome. The Journal of Clinical Pharmacology.
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Yiming Cheng, Shengnan Du, Hongxiang Hu, Xiaomin Wang, Leon Carayannopoulos & Yan Li. (2024) Integrating Full Bayesian Inference and Student's t‐Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug–Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients. The Journal of Clinical Pharmacology.
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Xueke Shi, Jin Yang, Shuzhi Deng, Hongdan Xu, Deyang Wu, Qingxiang Zeng, Shimeng Wang, Tao Hu, Fanglong Wu & Hongmei Zhou. (2022) TGF-β signaling in the tumor metabolic microenvironment and targeted therapies. Journal of Hematology & Oncology 15:1.
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Yiming Cheng, Xiaomin Wang, Zeen Tong, Josephine Reyes, Leon Carayannopoulos, Simon Zhou & Yan Li. (2021) Assessment of Transporter‐Mediated Drug Interactions for Enasidenib Based on a Cocktail Study in Patients With Relapse or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome. The Journal of Clinical Pharmacology 62:4, pages 494-504.
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Bin Fan, Yue Chen, Feng Yin, Lei Hua, Caroline Almon, Salah Nabhan, Michael Cooper, Hua Yang & Mohammad Hossain. (2022) Pharmacokinetic/Pharmacodynamic Evaluation of Ivosidenib or Enasidenib Combined With Intensive Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed IDH1/2 ‐Mutant Acute Myeloid Leukemia . Clinical Pharmacology in Drug Development 11:4, pages 429-441.
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Lamia Madaci, Julien Colle, Geoffroy Venton, Laure Farnault, Béatrice Loriod & Régis Costello. (2021) The contribution of single-cell analysis of acute leukemia in the therapeutic strategy. Biomarker Research 9:1.
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Zhiqiang Wang, Zhibo Zhang, Yong Li, Li Sun, Dezhen Peng, Danyu Du, Xian Zhang, Luwei Han, Liwen Zhao, Ligong Lu, Hongzhi Du, Shengtao Yuan & Meixiao Zhan. (2021) Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China. Acta Pharmaceutica Sinica B 11:6, pages 1526-1540.
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Juan Eduardo Megías-Vericat, Antonio Solana-Altabella, Octavio Ballesta-López, David Martínez-Cuadrón & Pau Montesinos. (2020) Drug-drug interactions of newly approved small molecule inhibitors for acute myeloid leukemia. Annals of Hematology 99:9, pages 1989-2007.
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Xiaomin Wang, Jian Chen, Josephine Reyes, Simon Zhou, Maria Palmisano & Yan Li. (2019) A Phase 1, Open-Label Study in Healthy Subjects to Evaluate the Absolute Bioavailability of AG-221 by a Microtracer Approach. Oncology and Therapy 8:1, pages 91-102.
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Shuang-long Li, Yong-liang Zhu, Yi Zhang, Shu-han Liu, Xiang-die Wang & Xiang-jun Qiu. (2020) Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application. International Journal of Analytical Chemistry 2020, pages 1-7.
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Yan Li, Liangang Liu, Diana Gomez, Jian Chen, Zeen Tong, Maria Palmisano & Simon Zhou. (2018) Pharmacokinetics and safety of Enasidenib following single oral doses in Japanese and Caucasian subjects. Pharmacology Research & Perspectives 6:6.
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