Xenobiotica, Volume 49, Issue 2 (2019)

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Xenobiotica, Volume 49, Issue 2 (2019)

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General Xenobiochemistry

Article
Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone
Kensaku Kakimoto, Norie Murayama, Shigeo Takenaka, Haruna Nagayoshi, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich & Tsutomu Shimada
Pages: 131-142
Published online: 29 Jan 2018
AbstractforCytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Predicting the dopamine D2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic–pharmacodynamic modeling
Chenrong Huang, Ziteng Wang, Linsheng Liu, Xiaoxue Liu, Ji Dong, Qingqing Xu, Bin Zhang & Liyan Miao
Pages: 143-151
Published online: 14 Mar 2018
AbstractforPredicting the dopamine D2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic–pharmacodynamic modeling | Full Text | References | PDF (643.6 KB) | EPUB
  • 196 Views
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Article
Metabolic characteristics of Tanshinone I in human liver microsomes and S9 subcellular fractions
Yue Li, Yujuan Fan, Huizong Su, Qian Wang, Guo-Fu Li, Yiyang Hu, Jian Jiang, Bo Tan & Furong Qiu
Pages: 152-160
Published online: 05 Feb 2018
AbstractforMetabolic characteristics of Tanshinone I in human liver microsomes and S9 subcellular fractions | Full Text | References | PDF (1.4 MB) | EPUB
  • 246 Views
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Article
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes
Shuting Wang, Xiange Tang, Tingting Yang, Jiong Xu, Jiaxin Zhang, Xiaodong Liu & Li Liu
Pages: 161-168
Published online: 08 Feb 2018
AbstractforPredicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes | Full Text | References | PDF (848.8 KB) | EPUB
  • 361 Views
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Article
Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole
Raghava Choudary Palacharla, Parusharamulu Molgara, Hanumanth Rao Panthangi, Rajesh Kumar Boggavarapu, Arun Kumar Manoharan, Ranjith Kumar Ponnamaneni, Devender Reddy Ajjala & Ramakrishna Nirogi
Pages: 169-176
Published online: 15 Feb 2018
AbstractforMethoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole | Full Text | References | PDF (790.6 KB) | EPUB
  • 307 Views
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Article
Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes
Marike Visser, Matthew J. Zaya, Charles W. Locuson, Dawn M. Boothe & Dawn A. Merritt
Pages: 177-186
Published online: 06 Mar 2018
AbstractforComparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 367 Views
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Clinical Pharmacokinetics and metabolism

Article
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes
Jade Huguet, Fleur Gaudette, Veronique Michaud & Jacques Turgeon
Pages: 187-199
Published online: 08 Mar 2018
AbstractforDevelopment and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 230 Views
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Article
Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans
Zeen Tong, Christian Atsriku, Usha Yerramilli, Xiaomin Wang, Yan Li, Josephine Reyes, Bin Fan, Hua Yang, Matthew Hoffmann & Sekhar Surapaneni
Pages: 200-210
Published online: 22 Jan 2018
AbstractforAbsorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans | Full Text | References | PDF (614 KB) | EPUB | Supplemental
  • 445 Views
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Animal Pharmacokinetics and metabolism

Article
Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism
Tonghui Li, Jijun Liu, Yingying Zheng, Shengchang Yang, Xun Liu & Xuejing Li
Pages: 211-215
Published online: 06 Mar 2018
AbstractforEffects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism | Full Text | References | PDF (583.3 KB) | EPUB
  • 153 Views
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Molecular Toxicology

Article
Investigation of the mechanisms of Genkwa Flos hepatotoxicity by a cell metabolomics strategy combined with serum pharmacology in HL-7702 liver cells
Zhipeng Wang, Yuanyuan Zhang, Quanli Liu, Linjia Sun, Mingming Lv, Peipei Yu & Xiaohui Chen
Pages: 216-226
Published online: 31 Jan 2018
AbstractforInvestigation of the mechanisms of Genkwa Flos hepatotoxicity by a cell metabolomics strategy combined with serum pharmacology in HL-7702 liver cells | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats
Corinne Haines, Lynsey R. Chatham, Audrey Vardy, Clifford R. Elcombe, John R. Foster & Brian G. Lake
Pages: 227-238
Published online: 26 Mar 2018
AbstractforComparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats | Full Text | References | PDF (1.6 MB) | EPUB
  • 286 Views
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Xenobiotic transporters

Article
Interaction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3
Yanli Lu, Qingqing Hu, Lin Chen, Hong Zhang, Shibo Huang, Yuqing Xiong & Chunhua Xia
Pages: 239-246
Published online: 18 Feb 2018
AbstractforInteraction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3 | Full Text | References | PDF (1.6 MB) | EPUB
  • 226 Views
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Pharmacogenetics

Article
Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver
Yasuhiro Uno, Yoshiyuki Igawa, Maori Tanaka, Kayoko Ohura, Masakiyo Hosokawa & Teruko Imai
Pages: 247-255
Published online: 27 Apr 2018
AbstractforAnalysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 219 Views
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