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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 2
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General Xenobiochemistry

Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes

Shuting WangCenter of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Xiange TangCenter of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Tingting YangCenter of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Jiong XuCenter of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Jiaxin ZhangCenter of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaView further author information
,
Xiaodong LiuCenter of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected]
View further author information
&
Li LiuCenter of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected]
View further author information
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Pages 161-168 | Received 11 Dec 2017, Accepted 25 Jan 2018, Published online: 08 Feb 2018

Citations (8)

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Read on this site (1)

Li-jun Luo, Xiao Liu, Yan Li, Yang Li & Li Sheng. Characterization of the metabolic contributions of cytochrome P450 isoforms to bicyclol using the relative activity factor method. Journal of Asian Natural Products Research 0:0, pages 1-12.
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Articles from other publishers (7)

Robert S. Foti, Joseph M. Roesner & Joshua T. Pearson. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 249 267 .
Angela C. Doran, Woodrow Burchett, Connor Landers, Gabrielle M. Gualtieri, Amanda Balesano, Heather Eng, Alyssa L Dantonio, Theunis C. Goosen & R. Scott Obach. (2022) Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach. Drug Metabolism and Disposition 50:9, pages 1259-1271.
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Angela C. Doran, Alyssa L. Dantonio, Gabrielle M. Gualtieri, Amanda Balesano, Connor Landers, Woodrow Burchett, Theunis C. Goosen & R. Scott Obach. (2022) An Improved Method for Cytochrome P450 Reaction Phenotyping Using a Sequential Qualitative-Then-Quantitative Approach. Drug Metabolism and Disposition 50:9, pages 1272-1286.
Crossref
Mo’tasem M. Alsmadi, Nour M. AL-Daoud, Rana M. Obaidat & Niazy A. Abu-Farsakh. (2022) Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid Technology Guided by wbPBPK Modeling in Rat and Human. AAPS PharmSciTech 23:5.
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Alyssa L. Dantonio, Angela C. Doran & R. Scott Obach. (2022) Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping. Drug Metabolism and Disposition 50:3, pages 249-257.
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Josefine Schulz, Antonia Thomas, Ayatallah Saleh, Gerd Mikus, Charlotte Kloft & Robin Michelet. (2022) Towards the Elucidation of the Pharmacokinetics of Voriconazole: A Quantitative Characterization of Its Metabolism. Pharmaceutics 14:3, pages 477.
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William Irwin. 2020. Information Resources in Toxicology. Information Resources in Toxicology 189 196 .

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