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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 4
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General Xenobiochemistry

Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations

Laura HedgesConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-3627-4711View further author information
ORCID Icon,
Susan BrownConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; View further author information
,
Audrey VardyConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; View further author information
,
Edward DoyleConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; View further author information
,
Miyoung YoonScitoVation, LLC, Research Triangle Park, NC, USA; View further author information
,
Thomas G. OsimitzScience Strategies, LLC, Charlottesville, VA, USA; View further author information
&
Brian G. LakeConcept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK; ;Centre for Toxicology, University of Surrey, Surrey, UKORCID Iconhttp://orcid.org/0000-0002-1571-5207View further author information
ORCID Icon show all
Pages 388-396 | Received 31 Jan 2018, Accepted 07 Mar 2018, Published online: 19 Apr 2018

Citations (11)

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Roger J. Price, Mary P. Scott, Carina Cantrill, Larry G. Higgins, Marjory Moreau, Miyoung Yoon, Harvey J. Clewell, Moire R. Creek, Thomas G. Osimitz, J. Brian Houston & Brian G. Lake. (2021) Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol. Xenobiotica 51:1, pages 40-50.
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Laura Hedges, Susan Brown, A. Kenneth MacLeod, Marjory Moreau, Miyoung Yoon, Moire R. Creek, Thomas G. Osimitz & Brian G. Lake. (2020) Metabolism of bifenthrin, β-cyfluthrin, λ-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes. Xenobiotica 50:12, pages 1434-1442.
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Laura Hedges, Susan Brown, A. Kenneth MacLeod, Audrey Vardy, Edward Doyle, Gina Song, Marjory Moreau, Miyoung Yoon, Thomas G. Osimitz & Brian G. Lake. (2019) Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes. Xenobiotica 49:5, pages 521-527.
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Articles from other publishers (8)

Derek Simonsen, Jacob Heffelfinger, David M. Cwiertny & Hans-Joachim Lehmler. (2023) Benoxacor is enantioselectively metabolized by microsomes and cytosol from the human liver. Emerging Contaminants 9:1, pages 100198.
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Vanessa Baier, Alicia Paini, Stephan Schaller, Colin G. Scanes, Audrey J. Bone, Markus Ebeling, Thomas G. Preuss, Johannes Witt & David Heckmann. (2022) A generic avian physiologically-based kinetic (PBK) model and its application in three bird species. Environment International 169, pages 107547.
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Larry G. Higgins, Lynsey R. Chatham, Sara L. Tomczynski, A. Kenneth MacLeod, Marjory Moreau, Harvey J. Clewell, Miyoung Yoon, Moire R. Creek, Thomas G. Osimitz & Brian G. Lake. (2020) Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats. Toxicology 443, pages 152563.
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Pankajini Mallick, Gina Song, Alina Y Efremenko, Salil N Pendse, Moire R Creek, Thomas G Osimitz, Ronald N Hines, Paul Hinderliter, Harvey J Clewell, Brian G Lake, Miyoung Yoon & Marjory Moreau. (2020) Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids. Toxicological Sciences 176:2, pages 460-469.
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Jing Pang, Tanzir Mortuza, Catherine A White, Srinavasa Muralidhara, Brian S Cummings & James V Bruckner. (2020) Toxicokinetics of cis- and trans-Permethrin: Influence of Isomer, Maturation, and Sex. Toxicological Sciences 174:1, pages 25-37.
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Pankajini Mallick, Marjory Moreau, Gina Song, Alina Y Efremenko, Salil N Pendse, Moire R Creek, Thomas G Osimitz, Ronald N Hines, Paul Hinderliter, Harvey J Clewell, Brian G Lake & Miyoung Yoon. (2020) Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans. Toxicological Sciences 173:1, pages 86-99.
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Marwa Mohamed Atef, Omnia Safwat El-Deeb, Mona Tayssir Sadek, Rehab E. Abo El Gheit, Marwa Nagy Emam, Yasser Mostafa Hafez & Rasha Osama El-Esawy. (2019) Targeting ERK/COX-2 signaling pathway in permethrin-induced testicular toxicity: a possible modulating effect of matrine. Molecular Biology Reports 47:1, pages 247-259.
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Vanessa Baier, Alicia Paini, Stephan Schaller, Colin G. Scanes, Audrey Bone, Markus Ebeling, Thomas G. Preuss, Johannes Witt & David Heckmann. (2022) A Generic Avian Physiologically-Based Kinetic (Pbk) Model and its Application in Three Bird Species. SSRN Electronic Journal.
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