Xenobiotica

the fate of foreign compounds in biological systems

Volume 49, 2019 - Issue 8

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Animal Pharmacokinetics and Metabolism

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

Chie MakinoDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan; Correspondence[email protected]

Akiko WatanabeDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan;

Tsuneo DeguchiBiomarker Department, Daiichi Sankyo Co., Ltd. Tokyo, Japan;

Hideyuki ShiozawaDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan;

Ilona SchreckTissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany;

Veronika RozehnalTissue and Cell Research Center Munich, Daiichi Sankyo Europe GmbH, Munich, Germany;

Tomoko IshizukaClinical Pharmacology Department, Daiichi Sankyo Co., Ltd. Tokyo, Japan;

Nobuaki WatanabeBiomarker Department, Daiichi Sankyo Co., Ltd. Tokyo, Japan;

Osamu AndoDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd. Tokyo, Japan;

Norie MurayamaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan

Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan

http://orcid.org/0000-0002-1068-4261

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In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

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In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions

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