Xenobiotica, Volume 49, Issue 8 (2019)

Browse this journal
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Xenobiotica, Volume 49, Issue 8 (2019)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Volume 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Microbial biotransformation – an important tool for the study of drug metabolism
Rhys Salter, Douglas C. Beshore, Steven L. Colletti, Liam Evans, Yong Gong, Roy Helmy, Yong Liu, Cheri M. Maciolek, Gary Martin, Natasa Pajkovic, Richard Phipps, James Small, Jonathan Steele, Ronald de Vries, Headley Williams & Iain J. Martin
Pages: 877-886
Published online: 21 Sep 2018
AbstractforMicrobial biotransformation – an important tool for the study of drug metabolism | Full Text | References | PDF (1.1 MB) | EPUB
  • 662 Views
  • 17 CrossRef citations
  • 0Altmetric
Article
In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans
Takashi Koyanagi, Koji Yano, Soonih Kim, Norie Murayama, Hiroshi Yamazaki & Ikumi Tamai
Pages: 887-894
Published online: 21 Sep 2018
AbstractforIn vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans | Full Text | References | PDF (940.9 KB) | EPUB
  • 400 Views
  • 6 CrossRef citations
  • 0Altmetric
Article
In vitro phase I metabolism of vinclozolin by human liver microsomes
Marycarmen Cruz-Hurtado, Ma de Lourdes López-González, Victor Mondragón & Adolfo Sierra-Santoyo
Pages: 895-904
Published online: 21 Dec 2018
AbstractforIn vitro phase I metabolism of vinclozolin by human liver microsomes | Full Text | References | PDF (1.5 MB) | EPUB
  • 236 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Effects of shuanghuanglian injection on the activities of CYP1A2, 2C11, 2D1 and 3A1/2 in rats in vivo and in vitro
Yuan Shi, Juan Xu, Yan Qiao, Wenlong Zhang, Duo Liu, Mengnan Qin, Gaofeng Liu & Mei Dong
Pages: 905-911
Published online: 08 Apr 2019
AbstractforEffects of shuanghuanglian injection on the activities of CYP1A2, 2C11, 2D1 and 3A1/2 in rats in vivo and in vitro | Full Text | References | PDF (922.4 KB) | EPUB | Supplemental
  • 146 Views
  • 3 CrossRef citations
  • 0Altmetric
Article
Physiologically-based pharmacokinetic modeling for mirabegron: a multi-elimination pathway mediated by cytochrome P450 3A4, uridine 5'-diphosphate-glucuronosyltransferase 2B7, and butyrylcholinesterase
Kentaro Konishi, Tsuyoshi Minematsu, Yasuhisa Nagasaka & Kenji Tabata
Pages: 912-921
Published online: 29 Nov 2018
AbstractforPhysiologically-based pharmacokinetic modeling for mirabegron: a multi-elimination pathway mediated by cytochrome P450 3A4, uridine 5'-diphosphate-glucuronosyltransferase 2B7, and butyrylcholinesterase | Full Text | References | PDF (1.9 MB) | EPUB
  • 446 Views
  • 6 CrossRef citations
  • 0Altmetric
Article
Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry
Agnieszka Potęga, Dorota Garwolińska, Anna M. Nowicka, Michał Fau, Agata Kot-Wasik & Zofia Mazerska
Pages: 922-934
Published online: 04 Jan 2019
AbstractforPhase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 150 Views
  • 9 CrossRef citations
  • 0Altmetric
Article
Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir in vitro
Su Nwe San, Jun Matsumoto, Yumi Saito, Masako Koike, Hiroaki Sakaue, Yoshinori Kato, Masachika Fujiyoshi, Noritaka Ariyoshi & Harumi Yamada
Pages: 935-944
Published online: 08 Nov 2018
AbstractforMinor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir in vitro | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 189 Views
  • 1 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
Intestinal phase-II metabolism of quercetin in HT29 cells, 3D human intestinal tissues and in healthy volunteers: a qualitative comparison using LC-IMS-MS and LC-HRMS
Clément Chalet, Boudewijn Hollebrands, Guus S. Duchateau & Patrick Augustijns
Pages: 945-952
Published online: 28 Sep 2018
AbstractforIntestinal phase-II metabolism of quercetin in HT29 cells, 3D human intestinal tissues and in healthy volunteers: a qualitative comparison using LC-IMS-MS and LC-HRMS | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 254 Views
  • 7 CrossRef citations
  • 0Altmetric
Article
19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers
David Pearson, Maxime Garnier, Alexandre Luneau, Alexander David James & Markus Walles
Pages: 953-960
Published online: 29 Nov 2018
Abstractfor19F-NMR-based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 517 Views
  • 11 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions
Chie Makino, Akiko Watanabe, Tsuneo Deguchi, Hideyuki Shiozawa, Ilona Schreck, Veronika Rozehnal, Tomoko Ishizuka, Nobuaki Watanabe, Osamu Ando, Norie Murayama & Hiroshi Yamazaki
Pages: 961-969
Published online: 28 Sep 2018
AbstractforIn vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 327 Views
  • 4 CrossRef citations
  • 0Altmetric
Article
Effect Of epigallocatechin-3-gallate on the pharmacokinetics of amlodipine in rats
Xiuyuan Han, Haixia Zhang, Huihui Hao, Hangao Li, Xichun Guo & Dong Zhang
Pages: 970-974
Published online: 16 Oct 2018
AbstractforEffect Of epigallocatechin-3-gallate on the pharmacokinetics of amlodipine in rats | Full Text | References | PDF (588.3 KB) | EPUB
  • 146 Views
  • 12 CrossRef citations
  • 0Altmetric
Article
Effect of diammonium glycyrrhizinate on pharmacokinetics of omeprazole by regulating cytochrome P450 enzymes and plasma protein binding rate
Lu Han, Rong Wang, Bin Wu, Yanqiu Gu & Yongfang Yuan
Pages: 975-980
Published online: 21 Dec 2018
AbstractforEffect of diammonium glycyrrhizinate on pharmacokinetics of omeprazole by regulating cytochrome P450 enzymes and plasma protein binding rate | Full Text | References | PDF (766.4 KB) | EPUB
  • 451 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Pharmacokinetic modeling and simulation of etodolac following single oral administration in dogs
In-Hwan Baek
Pages: 981-986
Published online: 11 Dec 2018
AbstractforPharmacokinetic modeling and simulation of etodolac following single oral administration in dogs | Full Text | References | PDF (866.4 KB) | EPUB
  • 109 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Evaluation of pharmacokinetic interactions between bicyclol and co-administered drugs in rat and human liver microsomes in vitro and in rats in vivo
Shu Yang, Jinping Hu, Yan Li & Zhigang Zhao
Pages: 987-994
Published online: 11 Dec 2018
AbstractforEvaluation of pharmacokinetic interactions between bicyclol and co-administered drugs in rat and human liver microsomes in vitro and in rats in vivo | Full Text | References | PDF (1.1 MB) | EPUB
  • 247 Views
  • 3 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques
Yasuhiro Uno, Norie Murayama, Kazuaki Tamura & Hiroshi Yamazaki
Pages: 995-1000
Published online: 06 Dec 2018
AbstractforFunctionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques | Full Text | References | PDF (929.9 KB) | EPUB
  • 95 Views
  • 6 CrossRef citations
  • 0Altmetric

Explore articles