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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 11
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Animal Pharmacokinetics and Metabolism

Metabolism study of hesperetin and hesperidin in rats by UHPLC-LTQ-Orbitrap MSn

Qishu Jiaoa School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, ChinaView further author information
,
Lulu Xua School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, ChinaView further author information
,
Lijuan Jianga School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, ChinaView further author information
,
Yanyan Jianga School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, ChinaView further author information
,
Jiayu Zhangb Beijing Research Institution of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCorrespondence[email protected]
View further author information
&
Bin Liua School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, ChinaCorrespondence[email protected]
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Pages 1311-1322 | Received 26 Nov 2018, Accepted 07 Jan 2019, Published online: 12 Aug 2020

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Aftab Ahmad, Muhammad Afzaal, Farhan Saeed, Shinawar Waseem Ali, Ali Imran, Syed Yaseen Raza Zaidi, Muhammad Awais Saleem, Muzzamal Hussain & Entessar Al Jbawi. (2023) A comprehensive review of the therapeutic potential of citrus bioflavonoid hesperidin against lifestyle-related disorders. Cogent Food & Agriculture 9:1.
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Yueying Bian, Mengqi Sun, Huili Chen, Guanghui Ren, Kejia Fu, Nan Yang, Mei Zhang, Nan Zhou, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen & Di Zhao. (2022) Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS. Xenobiotica 52:2, pages 165-176.
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Hongjun Xia. (2021) Extensive metabolism of flavonoids relevant to their potential efficacy on Alzheimer’s disease. Drug Metabolism Reviews 53:4, pages 563-591.
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Haijun Xiong, Jin Wang, Qian Ran, Guanhua Lou, Chengyi Peng, Qingxia Gan, Ju Hu, Jilin Sun, Renchuan Yao & Qinwan Huang. (2019) Hesperidin: A Therapeutic Agent For Obesity. Drug Design, Development and Therapy 13, pages 3855-3866.
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Arshad Husain Rahmani, Ali Yousif Babiker & Shehwaz Anwar. (2023) Hesperidin, a Bioflavonoid in Cancer Therapy: A Review for a Mechanism of Action through the Modulation of Cell Signaling Pathways. Molecules 28:13, pages 5152.
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Yang Yao, Mingyue Lin, Zhujun Liu, Mengyang Liu, Shiheng Zhang & Yukun Zhang. (2022) Hesperidin Inhibits Lung Cancer In Vitro and In Vivo Through PinX1. Frontiers in Pharmacology 13.
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Tingting Chen, Xinning Wang, Pan Chen, Yuying Zheng, Yan He, Xuan Zeng, Wei Peng & Weiwei Su. (2022) Chemical components analysis and in vivo metabolite profiling of Jian’er Xiaoshi oral liquid by UHPLC-Q-TOF-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 211, pages 114629.
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Tzu-Chien Chen, Yu-Yu Ho, Rui-Chian Tang, Yong-Chen Ke, Jhih-Ni Lin, I-Hsuan Yang & Feng-Huei Lin. (2021) Thiolated Chitosan as an Intestinal Absorption Carrier with Hesperidin Encapsulation for Obesity Treatment. Nutrients 13:12, pages 4405.
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Kah Min Yap, Mahendran Sekar, Yuan Seng Wu, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Lay Jing Seow, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria & Pei Teng Lum. (2021) Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects. Saudi Journal of Biological Sciences 28:12, pages 6730-6747.
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Yi Cao, Long Xie, Kai Liu, Youdan Liang, Xiaolin Dai, Xian Wang, Jing Lu, Xumin Zhang & Xiaofang Li. (2021) The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review. Pharmacological Research 174, pages 105919.
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Anallely López-Yerena, Inés Domínguez-López, Anna Vallverdú-Queralt, Maria Pérez, Olga Jáuregui, Elvira Escribano-Ferrer & Rosa M. Lamuela-Raventós. (2021) Metabolomics Technologies for the Identification and Quantification of Dietary Phenolic Compound Metabolites: An Overview. Antioxidants 10:6, pages 846.
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Feng Wang, Chengying Zhao, Minke Yang, Lin Zhang, Rujun Wei, Kun Meng, Yuming Bao, Lina Zhang & Jinkai Zheng. (2021) Four Citrus Flavanones Exert Atherosclerosis Alleviation Effects in ApoE –/– Mice via Different Metabolic and Signaling Pathways . Journal of Agricultural and Food Chemistry 69:17, pages 5226-5237.
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Anna Mas-Capdevila, Joan Teichenne, Cristina Domenech-Coca, Antoni Caimari, Josep M Del Bas, Xavier Escoté & Anna Crescenti. (2020) Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability. Nutrients 12:5, pages 1488.
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Rasha Al-Rikabi, Hanady Al-Shmgani, Yaser Hassan Dewir & Salah El-Hendawy. (2020) In Vivo and In Vitro Evaluation of the Protective Effects of Hesperidin in Lipopolysaccharide-Induced Inflammation and Cytotoxicity of Cell. Molecules 25:3, pages 478.
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