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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 3
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General Xenobiochemistry

Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery

Carl PeterssonNCE DMPK, Discovery Technology, HealthCare Merck KGaA, Darmstadt, Germany; Correspondence[email protected]
,
Orestis PapasouliotisMerck Institute for Pharmacometrics (an affiliate of HealthCare Merck KGaA, Darmstadt, Germany), Lausanne, Switzerland);
,
Marc LecomteNCE DMPK, Discovery Technology, HealthCare Merck KGaA, Darmstadt, Germany;
,
Lassina BadoloNCE DMPK, Discovery Technology, HealthCare Merck KGaA, Darmstadt, Germany;
&
Hugues DolgosR&D, HealthCare Merck KGaA, Darmstadt, Germany
Pages 270-279 | Received 24 Apr 2019, Accepted 26 May 2019, Published online: 19 Jun 2019

Citations (8)

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Read on this site (2)

Eva Sherbetjian, Sheila-Annie Peters & Carl Petersson. (2022) Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model. Xenobiotica 52:7, pages 661-668.
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Urban Fagerholm, Sven Hellberg, Jonathan Alvarsson, Staffan Arvidsson McShane & Ola Spjuth. (2021) In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models. Xenobiotica 51:12, pages 1366-1371.
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Articles from other publishers (6)

Shoko Inatani, Akiko Mizuno‐Yasuhira, Makoto Kamiya, Izumi Nishino, Helene D. Sabia & Hiromi Endo. (2021) Prediction of a clinically effective dose of THY1773, a novel V 1B receptor antagonist, based on preclinical data . Biopharmaceutics & Drug Disposition 42:5, pages 204-217.
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Shibin Mathew, David Tess, Woodrow Burchett, George Chang, Nathaniel Woody, Christopher Keefer, Christine Orozco, Jian Lin, Samantha Jordan, Shinji Yamazaki, Rhys Jones & Li Di. (2021) Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods. Journal of Pharmaceutical Sciences 110:4, pages 1799-1823.
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Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker & Philip Lienau. (2021) Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat. Drug Metabolism and Disposition 49:1, pages 53-61.
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Franco Lombardo, Jörg Bentzien, Giuliano Berellini & Ingo Muegge. (2021) In Silico Models of Human PK Parameters. Prediction of Volume of Distribution Using an Extensive Data Set and a Reduced Number of Parameters. Journal of Pharmaceutical Sciences 110:1, pages 500-509.
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Dong-Seok Yim & Suein Choi. (2020) Predicting human pharmacokinetics from preclinical data: volume of distribution. Translational and Clinical Pharmacology 28:4, pages 169.
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Giuliano Berellini & Franco Lombardo. (2019) An Accurate In Vitro Prediction of Human VD ss Based on the Øie–Tozer Equation and Primary Physicochemical Descriptors. 3. Analysis and Assessment of Predictivity on a Large Dataset . Drug Metabolism and Disposition 47:12, pages 1380-1387.
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