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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 4
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Clinical Pharmacokinetics and Metabolism

Absorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects

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Pages 427-434 | Received 29 May 2019, Accepted 17 Jul 2019, Published online: 07 Aug 2019

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Read on this site (3)

Martine Gehin, Robert F. Storey, Corine Bernaud & Jasper Dingemanse. (2023) Clinical pharmacology of selatogrel for self-administration by patients with suspected acute myocardial infarction. Expert Opinion on Drug Metabolism & Toxicology 19:10, pages 697-708.
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William A. E. Parker & Robert F. Storey. (2021) Novel approaches to P2Y12 inhibition and aspirin dosing. Platelets 32:1, pages 7-14.
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William A. E. Parker & Robert F. Storey. (2020) Pharmacology and potential role of selatogrel, a subcutaneous platelet P2Y12 receptor antagonist. Expert Opinion on Emerging Drugs 25:1, pages 1-6.
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Articles from other publishers (15)

Chih-hsuan Hsin, Jasper Dingemanse, Andrea Henrich, Corine Bernaud, Martine Gehin & Andreas Krause. (2023) Mind the Gap: Model-Based Switching from Selatogrel to Maintenance Therapy with Oral P2Y12 Receptor Antagonists. Biomolecules 13:9, pages 1365.
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Li-guo Ming, Dong-xia Hu, Cheng Zuo & Wen-jun Zhang. (2023) G protein-coupled P2Y12 receptor is involved in the progression of neuropathic pain. Biomedicine & Pharmacotherapy 162, pages 114713.
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Giulia Alagna, Paolo Mazzone, Marco Contarini & Giuseppe Andò. (2023) Dual Antiplatelet Therapy with Parenteral P2Y12 Inhibitors: Rationale, Evidence, and Future Directions. Journal of Cardiovascular Development and Disease 10:4, pages 163.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
Matthew L. CondakesAnna E. HurtleyDavid W. LinRhiannon Thomas-TranJuan del Pozo. 2022. 2022 Medicinal Chemistry Reviews. 2022 Medicinal Chemistry Reviews 571 484 .
Véronique Pons, Cédric Garcia, Naomi Tidten-Luksch, Aengus Mac Sweeney, Eva Caroff, Céline Galés & Markus A. Riederer. (2022) Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation. Biochemical Pharmacology 206, pages 115291.
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Dorota Danielak, Kornel Pawlak, Franciszek Główka & Marta Karaźniewicz-Łada. (2022) Influence of Genetic and Epigenetic Factors of P2Y12 Receptor on the Safety and Efficacy of Antiplatelet Drugs. Cardiovascular Drugs and Therapy.
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Uta Schilling, Chih‐Hsuan Hsin, Stephane Delahaye, Andreas Krause, Hauke Wuelfrath, Atef Halabi & Jasper Dingemanse. (2022) Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of the P2Y12 receptor antagonist selatogrel . Clinical and Translational Science 15:8, pages 1906-1915.
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Isabelle Zenklusen, Chih-Hsuan Hsin, Uta Schilling, Martin Kankam, Andreas Krause, Mike Ufer & Jasper Dingemanse. (2021) Transition from Syringe to Autoinjector Based on Bridging Pharmacokinetics and Pharmacodynamics of the P2Y12 Receptor Antagonist Selatogrel in Healthy Subjects. Clinical Pharmacokinetics 61:5, pages 687-695.
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Ad Roffel, Jan Jaap van Lier, Gerk Rozema & Ewoud-Jan van Hoogdalem. (2022) Predictability of Elimination and Excretion of Small Molecules in Animals and Humans, and its Impact on Dosimetry for human ADME Studies with Radiolabeled Drugs. Current Reviews in Clinical and Experimental Pharmacology 17:1, pages 26-38.
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Craig J. Beavers, Samuel. Aaron EffoePaul P. Dobesh. (2022) Selatogrel: A Novel Subcutaneous P2Y12 Inhibitor. Journal of Cardiovascular Pharmacology 79:2, pages 161-167.
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Andrea Henrich, Christian Hove Claussen, Jasper Dingemanse & Andreas Krause. (2021) Pharmacokinetic/pharmacodynamic modeling of drug interactions at the P2Y 12 receptor between selatogrel and oral P2Y 12 antagonists . CPT: Pharmacometrics & Systems Pharmacology 10:7, pages 735-747.
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Uta Schilling, Jasper Dingemanse, Christine Voors‐Pette, Christel Romeijn, Peter Dogterom & Mike Ufer. (2020) Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel. Clinical and Translational Science 13:5, pages 886-890.
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Bastiaan Zwart, William A. E. Parker & Robert F. Storey. (2020) New Antithrombotic Drugs in Acute Coronary Syndrome. Journal of Clinical Medicine 9:7, pages 2059.
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Uta Schilling, Jasper Dingemanse & Mike Ufer. (2020) Pharmacokinetics and Pharmacodynamics of Approved and Investigational P2Y12 Receptor Antagonists. Clinical Pharmacokinetics 59:5, pages 545-566.
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