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Xenobiotica
the fate of foreign compounds in biological systems
Volume 50, 2020 - Issue 9
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General Xenobiochemistry

Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment

Shin-ichiro OgawaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
,
Makiko ShimizuLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan
&
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-1068-4261
ORCID Icon
Pages 1023-1031 | Received 14 Nov 2019, Accepted 21 Dec 2019, Published online: 03 Jan 2020

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Shin-ichiro Ogawa, Makiko Shimizu & Hiroshi Yamazaki. (2020) Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations. Xenobiotica 50:12, pages 1413-1422.
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Articles from other publishers (4)

Gautam Vijaywargi, Sivacharan Kollipara, Tausif Ahmed & Siddharth Chachad. (2022) Predicting transporter mediated drug–drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where we are now and the way forward. Biopharmaceutics & Drug Disposition 44:3, pages 195-220.
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Xiaoyan Chu, Bhagwat Prasad, Sibylle Neuhoff, Kenta Yoshida, James Steven Leeder, Dwaipayan Mukherjee, Kunal Taskar, Manthena V. S. Varma, Xinyuan Zhang, Xinning Yang & Aleksandra Galetin. (2022) Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective . Clinical Pharmacology & Therapeutics 112:3, pages 501-526.
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Hong Shen, Zheng Yang & A. David Rodrigues. (2022) Cynomolgus Monkey as an Emerging Animal Model to Study Drug Transporters: In Vitro, In Vivo, In Vitro-to-In Vivo Translation. Drug Metabolism and Disposition 50:3, pages 299-319.
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Eman El‐Khateeb, Adam S. Darwich, Brahim Achour, Varinder Athwal & Amin Rostami‐Hodjegan. (2021) Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment. Alimentary Pharmacology & Therapeutics 54:4, pages 388-401.
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