Xenobiotica, Volume 50, Issue 9 (2020)

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Xenobiotica, Volume 50, Issue 9 (2020)

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General Xenobiochemistry

Article
The biotransformation of Bupleuri Radix by human gut microbiota
Cui Tang, Qiachi Fu, Xia Chen, Yang Hu, Helen Renaud, Chong Ma, Tai Rao, Yao Chen, Zhirong Tan, Curtis D. Klaassen, Shuyun Shi & Ying Guo
Pages: 1011-1022
Published online: 16 Jan 2020
AbstractforThe biotransformation of Bupleuri Radix by human gut microbiota | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 192 Views
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Article
Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment
Shin-ichiro Ogawa, Makiko Shimizu & Hiroshi Yamazaki
Pages: 1023-1031
Published online: 03 Jan 2020
AbstractforPlasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment | Full Text | References | PDF (1.4 MB) | EPUB
  • 431 Views
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Article
Evaluation of in vitro absorption, distribution, metabolism, and excretion and assessment of drug-drug interaction of rucaparib, an orally potent poly(ADP-ribose) polymerase inhibitor
Mingxiang Liao, Sarah Jaw-Tsai, Jeri Beltman, Andrew D. Simmons, Thomas C. Harding & Jim J. Xiao
Pages: 1032-1042
Published online: 18 Mar 2020
AbstractforEvaluation of in vitro absorption, distribution, metabolism, and excretion and assessment of drug-drug interaction of rucaparib, an orally potent poly(ADP-ribose) polymerase inhibitor | Full Text | References | PDF (945.7 KB) | EPUB
  • 414 Views
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Article
Effects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line
Zhenyue Wang, Yongtao Liu, Xiaohui Ai, Liqiao Zhong, Gang Han, Jinlong Song, Qiuhong Yang & Jing Dong
Pages: 1043-1051
Published online: 12 Mar 2020
AbstractforEffects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line | Full Text | References | PDF (1.9 MB) | EPUB
  • 232 Views
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Article
Identification of rhythmic human CYPs and their circadian regulators using synchronized hepatoma cells
Min Chen, Cui Zhou, Tianpeng Zhang & Baojian Wu
Pages: 1052-1063
Published online: 09 Mar 2020
AbstractforIdentification of rhythmic human CYPs and their circadian regulators using synchronized hepatoma cells | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 408 Views
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Article
In vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization
Keiichi Morita, Motohiro Kato, Toshiyuki Kudo & Kiyomi Ito
Pages: 1064-1075
Published online: 12 Mar 2020
AbstractforIn vitro–in vivo extrapolation of metabolic clearance using human liver microsomes: factors showing variability and their normalization | Full Text | References | PDF (1.1 MB) | EPUB
  • 744 Views
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Article
Metabolic profiling of coumarins by the combination of UPLC-MS-based metabolomics and multiple mass defect filter
Yao Xiao, Yi-Kun Wang, Xue-Rong Xiao, Qi Zhao, Jian-Feng Huang, Wei-Feng Zhu & Fei Li
Pages: 1076-1089
Published online: 26 Mar 2020
AbstractforMetabolic profiling of coumarins by the combination of UPLC-MS-based metabolomics and multiple mass defect filter | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Pharmacokinetic and pharmacodynamic modeling of levetiracetam: investigation of factors affecting the clinical outcome
Eleni Karatza, Sophia L. Markantonis, Andria Savvidou, Anastasia Verentzioti, Anna Siatouni, Athanasia Alexoudi, Stylianos Gatzonis, Evgenia Mavrokefalou & Vangelis Karalis
Pages: 1090-1100
Published online: 07 Apr 2020
AbstractforPharmacokinetic and pharmacodynamic modeling of levetiracetam: investigation of factors affecting the clinical outcome | Full Text | References | PDF (2 MB) | EPUB
  • 348 Views
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Animal Pharmacokinetics and Metabolism

Review
Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans
Nathalie Rioux, Sherri Smith, Federico Colombo, Amy Kim, W. George Lai, Darrell Nix, Y. Amy Siu, Joanne Schindler & Peter G. Smith
Pages: 1101-1114
Published online: 06 Jan 2020
AbstractforMetabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Article
Effects of multidose simvastatin co-administration on pharmacokinetic profile of apatinib in rats by UPLC-MS/MS
Jinglin Gao, Huan Ren, Zhangying Feng, Shanshan Chen, Yu Liang, Wanqiu Liu, Qian Zhou & Mingxia Wang
Pages: 1115-1120
Published online: 19 Mar 2020
AbstractforEffects of multidose simvastatin co-administration on pharmacokinetic profile of apatinib in rats by UPLC-MS/MS | Full Text | References | PDF (839.7 KB) | EPUB
  • 137 Views
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Xenobiotic transporters

Article
Usefulness of novobiocin as a selective inhibitor of intestinal breast cancer resistance protein (Bcrp) in rats
Kei Suzuki, Kazuhiro Taniyama, Takao Aoyama & Yoshiaki Watanabe
Pages: 1121-1127
Published online: 03 Jan 2020
AbstractforUsefulness of novobiocin as a selective inhibitor of intestinal breast cancer resistance protein (Bcrp) in rats | Full Text | References | PDF (802.3 KB) | EPUB
  • 364 Views
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Article
Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1’s hypothesized function?
Dallas Bednarczyk & Menaka V. Sanghvi
Pages: 1128-1137
Published online: 26 Mar 2020
AbstractforOrganic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1’s hypothesized function? | Full Text | References | PDF (1.7 MB) | EPUB
  • 772 Views
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