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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 2
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General Xenobiochemistry

Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer–Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro

Kaori MatsumotoFaculty of Pharmaceutical Sciences, Josai International University, Togane, JapanORCID Iconhttps://orcid.org/0000-0001-7533-6025
ORCID Icon,
Tetsuya HasegawaFaculty of Pharmaceutical Sciences, Josai International University, Togane, Japan
,
Kosuke OharaFaculty of Pharmaceutical Sciences, Josai International University, Togane, Japan
,
Tomoyo KameiFaculty of Pharmaceutical Sciences, Josai International University, Togane, Japan
,
Junichi KoyanagiFaculty of Pharmaceutical Sciences, Josai International University, Togane, Japan
&
Masayuki AkimotoFaculty of Pharmaceutical Sciences, Josai International University, Togane, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8129-4028
ORCID Icon
Pages 155-166 | Received 07 Sep 2020, Accepted 24 Oct 2020, Published online: 16 Nov 2020

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S. Cyrus Khojasteh, Upendra A. Argikar, Sungjoon Cho, Rachel Crouch, Carley J. S. Heck, Kevin M. Johnson, Amit S. Kalgutkar, Lloyd King, Hlaing (Holly) Maw, Herana Kamal Seneviratne, Shuai Wang, Cong Wei, Donglu Zhang & Klarissa D. Jackson. (2022) Biotransformation novel advances – 2021 year in review. Drug Metabolism Reviews 54:3, pages 207-245.
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Nikhilesh V. Dhuria, Bianka Haro, Amit Kapadia, Khadjia A. Lobo, Bernice Matusow, Mary A. Schleiff, Christina Tantoy & Jasleen K. Sodhi. (2021) Recent developments in predicting CYP-independent metabolism. Drug Metabolism Reviews 53:2, pages 188-206.
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Mario Öeren, Peter A. Hunt, Charlotte E. Wharrick, Hamed Tabatabaei Ghomi & Matthew D. Segall. Predicting routes of phase I and II metabolism based on quantum mechanics and machine learning. Xenobiotica 0:0, pages 1-49.
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Articles from other publishers (8)

Klaudia M. Maksymiuk, Mateusz Szudzik, Emilia Samborowska, Dawid Chabowski, Marek Konop & Marcin Ufnal. (2024) Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases. PLOS ONE 19:1, pages e0297474.
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John Richard Cashman. 2024. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
F. Peter Guengerich, Yasuhiro Tateishi & Kevin D. McCarty. (2023) C-C bond cleavage reactions catalyzed by cytochrome P450 enzymes. Medicinal Chemistry Research 32:7, pages 1263-1277.
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Emre M. Isin. (2023) Unusual Biotransformation Reactions of Drugs and Drug Candidates. Drug Metabolism and Disposition 51:4, pages 413-426.
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Yuma SHIBATA, Kaori MATSUMOTO, Tetsuya HASEGAWA, Kosuke OHARA & Masayuki AKIMOTO. (2023) Weak Inhibitory Effects of Anthocyanins on Human Aldehyde Oxidase Activity: An In Vitro Study. Journal of Nutritional Science and Vitaminology 69:1, pages 71-75.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Xiaoyan Pang, Chongzhuang Tang, Runcong Guo & Xiaoyan Chen. (2022) Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & Therapeutics 233, pages 108020.
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Gianluca Catucci, Gianfranco Gilardi & Sheila J. Sadeghi. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 509 562 .

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