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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 5
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Animal Pharmacokinetics and Metabolism

Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

Shotaro Ueharaa Central Institute for Experimental Animals, Kawasaki, JapanORCID Iconhttps://orcid.org/0000-0002-1359-8828
ORCID Icon,
Nao Yonedaa Central Institute for Experimental Animals, Kawasaki, Japan
,
Yuichiro Higuchia Central Institute for Experimental Animals, Kawasaki, Japan
,
Hiroshi Yamazakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0002-1068-4261
ORCID Icon &
Hiroshi Suemizua Central Institute for Experimental Animals, Kawasaki, JapanORCID Iconhttps://orcid.org/0000-0002-3706-2454
ORCID Icon
Pages 582-589 | Received 20 Nov 2020, Accepted 10 Jan 2021, Published online: 18 Feb 2021

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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica 51:10, pages 1146-1154.
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Articles from other publishers (11)

Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Tatsunori Masatani & Hiroshi Yamazaki. (2023) Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver . Xenobiotica, pages 1-11.
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Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki & Hiroshi Suemizu. (2023) The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug Metabolism and Disposition 51:4, pages 480-491.
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永敏 刘. (2023) Research Progress of CYP450 Substrates, Inhibitors, Inducers and Species Specificity. Pharmacy Information 12:02, pages 70-80.
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Naoki Cho, Hiroshi Suemizu, Hidetaka Kamimura, Tomoyuki Ohe, Fumi Ito, Hidetaka Akita & Kaoru Kobayashi. (2022) Formation of reactive metabolites of benzbromarone in humanized-liver mice. Drug Metabolism and Pharmacokinetics 47, pages 100467.
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Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki & Hiroshi Suemizu. (2022) Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism. Scientific Reports 12:1.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2022) Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers. Drug Metabolism and Pharmacokinetics 44, pages 100454.
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Shotaro Uehara, Makiko Shimizu, Karen Plé, Sylvain Routier, Nao Yoneda, Yuichiro Higuchi, Hiroshi Suemizu & Hiroshi Yamazaki. (2022) Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo. Drug Metabolism and Pharmacokinetics 44, pages 100453.
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Pamela Bachour-El Azzi, Christophe Chesné & Shotaro Uehara. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 285 305 .
Shotaro Uehara, Hiroshi Suemizu & Hiroshi Yamazaki. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 307 328 .
Xiaoting Hua, Quan Zhang, Wei Xu, Xiaogang Wang, Fei Wang, Ping Zhao & Qingyou Xia. (2021) The Antiviral Molecule 5-Pyridoxolactone Identified Post BmNPV Infection of the Silkworm, Bombyx mori. International Journal of Molecular Sciences 22:14, pages 7423.
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