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Xenobiotica

the fate of foreign compounds in biological systems

Volume 51, 2021 - Issue 5

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Animal Pharmacokinetics and Metabolism

Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

Shotaro Ueharaa Central Institute for Experimental Animals, Kawasaki, Japan

https://orcid.org/0000-0002-1359-8828

Nao Yonedaa Central Institute for Experimental Animals, Kawasaki, Japan

Yuichiro Higuchia Central Institute for Experimental Animals, Kawasaki, Japan

Hiroshi Yamazakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan

https://orcid.org/0000-0002-1068-4261

Hiroshi Suemizua Central Institute for Experimental Animals, Kawasaki, Japan

https://orcid.org/0000-0002-3706-2454

Pages 582-589 | Received 20 Nov 2020, Accepted 10 Jan 2021, Published online: 18 Feb 2021

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https://doi.org/10.1080/00498254.2021.1875515
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