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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 6
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General Xenobiochemistry

Amalgamation of in-silico, in-vitro and in-vivo approach to establish glabridin as a potential CYP2E1 inhibitor

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Pages 625-635 | Received 13 Nov 2020, Accepted 27 Jan 2021, Published online: 15 Feb 2021

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Jianhong Zhang, Xinhui Wu, Baiyin Zhong, Qicheng Liao, Xin Wang, Yuankang Xie & Xiao He. (2023) Review on the Diverse Biological Effects of Glabridin. Drug Design, Development and Therapy 17, pages 15-37.
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Lu Zhan, Xue Tian, Jing Lin, Xudong Peng & Guiqiu Zhao. (2023) Glabridin Inhibits Aspergillus fumigatus Growth and Alleviate Inflammation Mediated by Dectin-2 and NLRP3 Inflammasome. Current Eye Research 48:4, pages 348-356.
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Shipra Bhatt, Ankita Sharma, Ashish Dogra, Priyanka Sharma, Amit Kumar, Pankul Kotwal, Swarnendu Bag, Prashant Misra, Gurdarshan Singh, Ajay Kumar, Payare Lal Sangwan & Utpal Nandi. (2022) Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress. Drug and Chemical Toxicology 45:5, pages 2352-2360.
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Raghu Rai Sharma, Haroon Rashid, Aalim Maqsood Bhat, Archoo Sajeeda, Ragni Gupta & Sheikh Tasduq Abdullah. (2023) Glabridin ameliorates intracellular events caused by palmitic acid and alcohol in mouse hepatocytes and fast food diet and alcohol -induced steatohepatitis and fibrosis in C57BL/6J mice model. Food and Chemical Toxicology 180, pages 114038.
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Ashiya Jamwal, Jagdish Chand, Anshurekha Dash, Shipra Bhatt, Sumit Dhiman, Priya Wazir, Buddh Singh, Anindya Goswami & Utpal Nandi. (2023) Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer. Chemico-Biological Interactions 382, pages 110605.
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Guiming Hu, Yan Fang, Haiwei Xu, Guanzhe Wang, Rui Yang, Fei Gao, Qingda Wei, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Na Gao, Qiang Wen & Hailing Qiao. (2023) Identification of Cytochrome P450 2E1 as a Novel Target in Glioma and Development of Its Inhibitor as an Anti‐Tumor Agent. Advanced Science 10:23.
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Pankul Kotwal, Parul Khajuria, Sumit Dhiman, Dilpreet Kour, Shakti Kumar Dhiman, Ajay Kumar & Utpal Nandi. (2023) Molecular mechanism for the involvement of CYP2E1/NF-κB axis in bedaquiline-induced hepatotoxicity. Life Sciences 315, pages 121375.
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Ravi Singh Manhas, Syed Mudabir Ahmad, Khalid Bashir Mir, Ajaz Ahmed, Snigdha Sharma, Diksha Manhas, Harshita Tiwari, Amit Kumar, Amit Nargotra, Utpal Nandi, Debaraj Mukherjee, Anindya Goswami & Asha Chaubey. (2022) Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region. Chemico-Biological Interactions 365, pages 110093.
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Manal Alhusban, Pankaj Pandey, Jongmin Ahn, Bharathi Avula, Saqlain Haider, Cristina Avonto, Zulfiqar Ali, Shabana I. Khan, Daneel Ferreira, Ikhlas A. Khan & Amar G. Chittiboyina. (2022) Computational Tools to Expedite the Identification of Potential PXR Modulators in Complex Natural Product Mixtures: A Case Study with Five Closely Related Licorice Species. ACS Omega 7:30, pages 26824-26843.
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Shipra Bhatt, Sumit Dhiman, Vinay Kumar, Abhishek Gour, Diksha Manhas, Kuhu Sharma, Probir Kumar Ojha & Utpal Nandi. (2022) Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico , In Vitro , and In Vivo Approaches . ACS Omega 7:23, pages 20321-20331.
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Shipra Bhatt, Diksha Manhas, Vinay Kumar, Abhishek Gour, Kuhu Sharma, Ashish Dogra, Probir Kumar Ojha & Utpal Nandi. (2022) Effect of Myricetin on CYP2C8 Inhibition to Assess the Likelihood of Drug Interaction Using In Silico , In Vitro , and In Vivo Approaches . ACS Omega 7:15, pages 13260-13269.
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Ashish Dogra, Divya Gupta, Swarnendu Bag, Irfan Ahmed, Shipra Bhatt, Ekta Nehra, Shakti Dhiman, Amit Kumar, Gurdarshan Singh, Sheikh Tasduq Abdullah, Payare Lal Sangwan & Utpal Nandi. (2021) Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis. Life Sciences 278, pages 119583.
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