Xenobiotica, Volume 51, Issue 6 (2021)

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Xenobiotica, Volume 51, Issue 6 (2021)

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General Xenobiochemistry

Article
Amalgamation of in-silico, in-vitro and in-vivo approach to establish glabridin as a potential CYP2E1 inhibitor
Shipra Bhatt, Vinay Kumar, Ashish Dogra, Probir Kumar Ojha, Priya Wazir, Payare Lal Sangwan, Gurdarshan Singh & Utpal Nandi
Pages: 625-635
Published online: 15 Feb 2021
AbstractforAmalgamation of in-silico, in-vitro and in-vivo approach to establish glabridin as a potential CYP2E1 inhibitor | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models
Tomonori Miura, Yusuke Kamiya, Shotaro Uehara, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu & Hiroshi Yamazaki
Pages: 636-642
Published online: 07 Apr 2021
AbstractforHepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Colchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens
Eleni Karatza, George Ismailos & Vangelis Karalis
Pages: 643-656
Published online: 12 Apr 2021
AbstractforColchicine for the treatment of COVID-19 patients: efficacy, safety, and model informed dosage regimens | Full Text | References | PDF (3 MB) | EPUB
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Article
Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia
Stacey M. Tuey, Amandla Atilano-Roque, Georgia Charkoftaki, Joshua M. Thurman, Thomas D. Nolin & Melanie S. Joy
Pages: 657-667
Published online: 18 Apr 2021
AbstractforInfluence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Evaluation of the drug–drug interaction potential for trazpiroben (TAK-906), a D2/D3 receptor antagonist for gastroparesis, towards cytochrome P450s and transporters
Mitsuhiro Nishihara, Diane Ramsden & Suresh K. Balani
Pages: 668-679
Published online: 21 Apr 2021
AbstractforEvaluation of the drug–drug interaction potential for trazpiroben (TAK-906), a D2/D3 receptor antagonist for gastroparesis, towards cytochrome P450s and transporters | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Open Access

Animal Pharmacokinetics and Metabolism

Article
Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties
Jie Liu & Tian-Rui Xia
Pages: 680-688
Published online: 07 Apr 2021
AbstractforIdentification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes
AtLee T. D. Watson, Benjamin C. Moeller, Melanie Doyle-Eisele, Edwin Garner, Chad R. Blystone, Jacob D. McDonald & Suramya Waidyanatha
Pages: 689-702
Published online: 26 Mar 2021
AbstractforDisposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model
Lijuan Wang, Keke Che & Yan Liu
Pages: 703-715
Published online: 06 May 2021
AbstractforPharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model | Full Text | References | PDF (2.7 MB) | EPUB
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Molecular Toxicology

Article
FXR activation prevents liver injury induced by Tripterygium wilfordii preparations
Wan Peng, Man-Yun Dai, Li-Juan Bao, Wei-Feng Zhu & Fei Li
Pages: 716-727
Published online: 30 Mar 2021
AbstractforFXR activation prevents liver injury induced by Tripterygium wilfordii preparations | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Xenobiotic Transporters

Article
In vitro evaluation of intestinal absorption of tiliroside from Edgeworthia gardneri (Wall.) Meisn.
Xiongwei Yin, Min Wang & Zhining Xia
Pages: 728-736
Published online: 20 Apr 2021
AbstractforIn vitro evaluation of intestinal absorption of tiliroside from Edgeworthia gardneri (Wall.) Meisn. | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Pharmacogenetics

Article
Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case–control study
Gislaine Dionísio Ferreira, Glaucia Maria de Mendonça Fernandes, Camila Penteado, Vivian Romanholi Cória, Ana Lívia da Silva Galbiatti-Dias, Anelise Russo, Márcia Maria Urbanin Castanhole-Nunes, Renato Ferreira da Silva, Rita de Cássia Martins Alves da Silva, Érika Cristina Pavarino, Mariangela Torreglosa Ruiz Cintra & Eny Maria Goloni-Bertollo
Pages: 737-744
Published online: 26 Apr 2021
AbstractforPolymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case–control study | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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