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Xenobiotica
the fate of foreign compounds in biological systems
Volume 51, 2021 - Issue 6
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Molecular Toxicology

FXR activation prevents liver injury induced by Tripterygium wilfordii preparations

Wan Penga State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China;b University of Chinese Academy of Sciences, Beijing, China;c Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaView further author information
,
Man-Yun Daia State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China;b University of Chinese Academy of Sciences, Beijing, China;c Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaView further author information
,
Li-Juan Baoa State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China;b University of Chinese Academy of Sciences, Beijing, China;d School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi Province, ChinaView further author information
,
Wei-Feng Zhue Academician Workstation, Jiangxi University of Traditional Chinese Medicine, Nanchang, ChinaView further author information
&
Fei Lia State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China;c Laboratory of Metabolomics and Drug-Induced Liver Injury, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaCorrespondence[email protected] [email protected]
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Pages 716-727 | Received 15 Jan 2021, Accepted 03 Mar 2021, Published online: 30 Mar 2021

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Zhuoling An, Yuan Sun, Chen Shi & Lihong Liu. (2023) Metabonomic and transcriptomic analyses of Tripterygium glycosides tablet-induced hepatotoxicity in rats. Drug and Chemical Toxicology 46:4, pages 650-664.
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Articles from other publishers (12)

Lei Zhang, Langqing Lu, Shiqin Jiang, Zhaokun Yin, Guoyao Tan, Fangqing Ning, Zhiyan Qin, Junyuan Huang, Min Huang & Jing Jin. (2024) Salvianolic acid extract prevents Tripterygium wilfordii polyglycosides-induced acute liver injury by modulating bile acid metabolism. Journal of Ethnopharmacology 327, pages 117939.
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Wenjing Tao, Qiwen Fan & Jintao Wei. (2024) Gut–Liver Axis as a Therapeutic Target for Drug-Induced Liver Injury. Current Issues in Molecular Biology 46:2, pages 1219-1236.
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Manyun Dai, Wan Peng, Lisha Lin, Zhanxuan E Wu, Ting Zhang, Qi Zhao, Yan Cheng, Qiuxia Lin, Binbin Zhang, Aiming Liu, Qianru Rao, Jianfeng Huang, Jinhua Zhao, Frank J. Gonzalez & Fei Li. (2023) Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. Phytomedicine 121, pages 155054.
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Yingkun Sheng, Guibing Meng, Zhirong Zhou, Ruijiao Du, Yuefei Wang & Miaomiao Jiang. (2023) PARP-1 inhibitor alleviates liver lipid accumulation of atherosclerosis via modulating bile acid metabolism and gut microbes . Molecular Omics 19:7, pages 560-573.
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Qiuyan Guo, Jiangpeng Wu, Qixin Wang, Yuwen Huang, Lin Chen, Jie Gong, Maobo Du, Guangqing Cheng, Tianming Lu, Minghong Zhao, Yuan Zhao, Chong Qiu, Fei Xia, Junzhe Zhang, Jiayun Chen, Feng Qiu & Jigang Wang. (2023) Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice. Journal of Pharmaceutical Analysis 13:8, pages 908-925.
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Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Lakshana D. Puttahanumantharayappa, Shreyas H. Karunakara, Smitha Bhat, Shashanka K. Prasad, Divya P. Kumar & Prasanna K. Santhekadur. (2023) The ameliorating effect of withaferin A on high-fat diet-induced non-alcoholic fatty liver disease by acting as an LXR/FXR dual receptor activator. Frontiers in Pharmacology 14.
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Qixin Wang, Yuwen Huang, Yu Li, Luyun Zhang, Huan Tang, Junzhe Zhang, Guangqing Cheng, Minghong Zhao, Tianming Lu, Qian Zhang, Piao Luo, Yinhua Zhu, Fei Xia, Ying Zhang, Dandan Liu, Chen Wang, Haiyan Li, Chong Qiu, Jigang Wang & Qiuyan Guo. (2022) Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress. Metabolites 12:11, pages 1128.
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Yingying Miao, Qin Zhang, Zihang Yuan, Jie Wang, Yunxia Xu, Yuanyuan Chai, Min Du, Qinwei Yu, Luyong Zhang & Zhenzhou Jiang. (2022) Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice. Frontiers in Pharmacology 13.
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Magdalena Rausch, Sophia L. Samodelov, Michele Visentin & Gerd A. Kullak-Ublick. (2022) The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity. International Journal of Molecular Sciences 23:22, pages 13967.
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Yajing Li, Sen Li, Xiaoyong Xue, Ting Wang & Xiaojiaoyang Li. (2022) Integrating systematic pharmacology-based strategy and experimental validation to explore mechanism of Tripterygium glycoside on cholangiocyte-related liver injury. Chinese Herbal Medicines 14:4, pages 563-575.
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Wei Wu, Rui Cheng, Hamza Boucetta, Lei Xu, Jing–ru Pan, Min Song, Yu–ting Lu & Tai–jun Hang. (2022) Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin–Induced Nephrotic Syndrome Rat Models and Correlations With Efficacy and Hepatotoxicity. Frontiers in Pharmacology 13.
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Manyun Dai, Wan Peng, Ting Zhang, Qi Zhao, Xiaofang Ma, Yan Cheng, Chunyan Wang & Fei Li. (2022) Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury. Journal of Ethnopharmacology 289, pages 115090.
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