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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 1
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General Xenobiochemistry

A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites

Nobuyuki KakutaniDrug Metabolism & Pharmacokinetics Research Laboratories, Japan Tobacco Inc. Central Pharmaceutical Research Institute, Osaka, JapanCorrespondence[email protected]
,
Satoru KobayashiDrug Metabolism & Pharmacokinetics Research Laboratories, Japan Tobacco Inc. Central Pharmaceutical Research Institute, Osaka, Japan
,
Toshio TaniguchiDrug Metabolism & Pharmacokinetics Research Laboratories, Japan Tobacco Inc. Central Pharmaceutical Research Institute, Osaka, Japan
&
Yukihiro NomuraDrug Metabolism & Pharmacokinetics Research Laboratories, Japan Tobacco Inc. Central Pharmaceutical Research Institute, Osaka, Japan
Pages 16-25 | Received 19 Dec 2021, Accepted 24 Jan 2022, Published online: 09 Feb 2022

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Shuai Wang, Upendra A. Argikar, Lionel Cheruzel, Sungjoon Cho, Rachel D. Crouch, Deepika Dhaware, Carley J. S. Heck, Kevin M. Johnson, Amit S. Kalgutkar, Lloyd King, Joyce Liu, Bin Ma, Hlaing Maw, Grover P. Miller, Herana Kamal Seneviratne, Ryan H. Takahashi, Cong Wei & S. Cyrus Khojasteh. (2023) Bioactivation and reactivity research advances – 2022 year in review‡. Drug Metabolism Reviews 55:4, pages 267-300.
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Articles from other publishers (2)

Lars Weidolf & Ian Wilson. (2023) Minimizing the DILI potential of carboxylic acid-containing drugs: a perspective. Medicinal Chemistry Research 32:9, pages 2034-2047.
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Kaushik Mitra. (2022) Acyl Glucuronide and Coenzyme A Thioester Metabolites of Carboxylic Acid-Containing Drug Molecules: Layering Chemistry with Reactive Metabolism and Toxicology. Chemical Research in Toxicology 35:10, pages 1777-1788.
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