Xenobiotica, Volume 52, Issue 1 (2022)

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Xenobiotica, Volume 52, Issue 1 (2022)

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General Xenobiochemistry

Article
Invitro drug-drug interactions of decitabine and tetrahydrouridine involving drug transporters and drug metabolising enzymes
Carolina Säll & Christian Fogt Hjorth
Pages: 1-15
Published online: 29 Dec 2021
AbstractforInvitro drug-drug interactions of decitabine and tetrahydrouridine involving drug transporters and drug metabolising enzymes | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Open Access
Article
A cysteine trapping assay for risk assessment of reactive acyl CoA metabolites
Nobuyuki Kakutani, Satoru Kobayashi, Toshio Taniguchi & Yukihiro Nomura
Pages: 16-25
Published online: 09 Feb 2022
AbstractforA cysteine trapping assay for risk assessment of reactive acyl CoA metabolites | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation
David Pearson, Yi Jin, Andrea Romeo, Bertrand-Luc Birlinger, Hilmar Schiller, Yan Ji, Mithat Gunduz, Daniela Baldoni & Markus Walles
Pages: 26-37
Published online: 10 Feb 2022
AbstractforSpecies-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
The metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] cetagliptin in healthy volunteers
Jinmiao Lu, Yicong Bian, Hua Zhang, Dong Tang, Xusheng Tian, Xinyi Zhou, Zengyan Xu, Yating Xiong, Zheming Gu, Zhenwen Yu, Tong Wang, Juping Ding, Qiang Yu & Jinsong Ding
Pages: 38-45
Published online: 21 Feb 2022
AbstractforThe metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C] cetagliptin in healthy volunteers | Full Text | References | PDF (1.1 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Sex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats
Li-Xia Shen, Gao-Feng Liu, Ji-Shuang Song, Yu-Hang Cao, Xiong Peng, Rong-Rong Wu, Yan Cao, Xiao-Jun Chen, Zhaoying Liu, Zhi-Liang Sun & Yong Wu
Pages: 46-53
Published online: 07 Mar 2022
AbstractforSex differences in the pharmacokinetics and tissue residues of Macleaya cordata extracts in rats | Full Text | References | PDF (821.1 KB) | EPUB
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Article
Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys
Naotoshi Yamamura, Minoru Uchiyama, Makoto Takahashi, Tomoyo Honda & Yumi Nishiya
Pages: 54-64
Published online: 10 Mar 2022
AbstractforPharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys | Full Text | References | PDF (1.3 MB) | EPUB
  • 267 Views
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Article
Preclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment
Ji Yue (Jeff) Zhang, Jiangwei Zhang, Michael Kiffe, Markus Walles, Yi Jin, Joachim Blanz, Jerôme Dayer, Arevalo Sanchez, Chunye Zhang, Lijun Zhang, Ying Huang & Counde Oyang
Pages: 65-78
Published online: 02 Mar 2022
AbstractforPreclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Absorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats
Huan Cheng, Jinghua Yu, Chen Yang, Ning Zhang, Zhen Fan, Xiaojuan Zhang, Junchen Wang, Zhen Wang, Da-fang Zhong, Ji-Xiang He, Shu Yan & Xingxing Diao
Pages: 79-90
Published online: 27 Jan 2022
AbstractforAbsorption, distribution, metabolism, and excretion of [14C]TPN729 after oral administration to rats | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 171 Views
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Article
Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats
Liyuan Zhu, Jiahua Mei, Chaorui Peng, Yuancui Zhao, Yunkuan Liu, Lili Cui, Kun Zhang & Yunshu Ma
Pages: 91-98
Published online: 16 Feb 2022
AbstractforPharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats | Full Text | References | PDF (1.1 MB) | EPUB
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Pharmacogenetics

Article
N-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population
Lamia Chorfi, Azzedine Fercha, Faouzia Derouiche, Fatima Zohra Sebihi, Dallal Houhou, Keltoum Chorfi & Katia Bendjemana
Pages: 99-104
Published online: 16 Feb 2022
AbstractforN-Acetyltransferase 2, glutathione S-transferase gene polymorphisms and susceptibility to hepatocellular carcinoma in an Algerian population | Full Text | References | PDF (766.4 KB) | EPUB
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