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Xenobiotica
the fate of foreign compounds in biological systems
Volume 52, 2022 - Issue 8: 50th year of the DMDG
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Research Articles

A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism

Daniel J. Westona GSK, DMPK, Disposition and Biotransformation, Stevenage, UKCorrespondence[email protected]
,
Mehul Davea GSK, DMPK, Disposition and Biotransformation, Stevenage, UK
,
Kevin Colizzab GSK, DMPK, Disposition and Biotransformation, Collegeville, PA, USA
,
Steve Thomasa GSK, DMPK, Disposition and Biotransformation, Stevenage, UK
,
Laura Tomlinsonc GSK, DMPK, Discovery DMPK, Stevenage, UK
,
Richard Gregoryc GSK, DMPK, Discovery DMPK, Stevenage, UK
,
Claire Beaumonta GSK, DMPK, Disposition and Biotransformation, Stevenage, UK
,
Jill Pirhallab GSK, DMPK, Disposition and Biotransformation, Collegeville, PA, USA
&
Gordon J. Deara GSK, DMPK, Disposition and Biotransformation, Stevenage, UK
 show all
Pages 928-942 | Received 12 Aug 2022, Accepted 11 Oct 2022, Published online: 01 Nov 2022

Citations (3)

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Read on this site (2)

M. Walles, A. Pähler, E.M. Isin & Marie M. Ahlqvist. (2024) Meeting report of the 4th European biotransformation workshop. Xenobiotica 0:0, pages 1-6.
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Panhong Wei, Minghai Tang, Ziyan MA, Jiajia Zhao, Rui Wu & Li Wan. (2023) In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS. Xenobiotica 53:2, pages 106-113.
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Articles from other publishers (1)

Julia Shanu-Wilson, Samuel Coe, Liam Evans, Jonathan Steele & Stephen Wrigley. (2024) Small molecule drug metabolite synthesis and identification: why, when and how?. Drug Discovery Today 29:5, pages 103943.
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