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Xenobiotica
the fate of foreign compounds in biological systems
Volume 53, 2023 - Issue 3
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General Xenobiochemistry

Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs

Yasuhiro Unoa Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima-city, Kagoshima, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9040-1681View further author information
ORCID Icon,
Yutaro Nodab Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanView further author information
,
Saho Morikunib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanView further author information
,
Norie Murayamab Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanView further author information
&
Hiroshi Yamazakib Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1068-4261View further author information
ORCID Icon
Pages 140-148 | Received 17 Apr 2023, Accepted 04 May 2023, Published online: 11 May 2023

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Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu & Hiroshi Yamazaki. (2023) Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation. Xenobiotica 53:6-7, pages 465-473.
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Articles from other publishers (1)

Yasuhiro Uno, Makiko Shimizu & Hiroshi Yamazaki. (2024) A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models. Biochemical Pharmacology, pages 116124.
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