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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 8
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Research Article

Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activity in vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus).

W. M. ZWEERS-ZEILMAKER Faculty of Veterinary Medicine, Department of Veterinary Pharmacy, Pharmacology and Toxicology, and OE Research Institute of Toxicology, Utrecht University, Yalelaan 2, PO Box 80. 176, NL-3508 TD Utrecht, The Netherlands
,
G. J. HORBACH Faculty of Veterinary Medicine, Department of Veterinary Pharmacy, Pharmacology and Toxicology, and OE Research Institute of Toxicology, Utrecht University, Yalelaan 2, PO Box 80. 176, NL-3508 TD Utrecht, The Netherlands
&
R. F. WITKAMP* Faculty of Veterinary Medicine, Department of Veterinary Pharmacy, Pharmacology and Toxicology, and OE Research Institute of Toxicology, Utrecht University, Yalelaan 2, PO Box 80. 176, NL-3508 TD Utrecht, The Netherlands
Pages 769-780 | Published online: 22 Sep 2008

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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Hui-Hui Wang, Yang-Yun Zhu, Chuan-Li Chen, Xiao-Bo Huang, Miao-Chang Liu, Yun-Bing Zhou & Hua-Yue Wu. (2024) Transition-metal-free four-component reaction of nitriles and disulfides/diselenides. Chemical Communications 60:7, pages 862-865.
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Heather K. Knych, Rick M. Arthur, Daniel S. McKemie, Russell W. Baden, Kelsey Seminoff & Philip H. Kass. (2020) Pharmacokinetics and anti‐inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses. Equine Veterinary Journal 53:1, pages 102-116.
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Yinghua Li, Yingzu Zhu, Shiqun Xiang, Weibin Fan, Jiang Jin & Deguang Huang. (2020) Temperature controlled condensation of nitriles: efficient and convenient synthesis of β-enaminonitriles, 4-aminopyrimidines and 4-amidinopyrimidines in one system. RSC Advances 10:11, pages 6576-6583.
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Yingzu Zhu, Yinghua Li, Shiqun Xiang, Weibin Fan, Jiang Jin & Deguang Huang. (2019) Utilization of nitriles as the nitrogen source: practical and economical construction of 4-aminopyrimidine and β-enaminonitrile skeletons. Organic Chemistry Frontiers 6:17, pages 3071-3077.
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Atsushi Kawase, Hiroyuki Tanaka, Toru Otori, Kenji Matsuyama & Masahiro Iwaki. (2016) Effects of duration of phenytoin administration on mRNA expression of cytochrome P450 and P-glycoprotein in the liver and small intestine of rats. Asian Journal of Pharmaceutical Sciences 11:5, pages 662-667.
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Saoud A. M. Metwally, Maisa I. Abdel Moneim, Yasser A. Elossely, Radwa I. Awad & Khaled Abou-Hadeed. (2010) Synthesis and crystal structure of some 3,5-pyrazolidinediones. Chemistry of Heterocyclic Compounds 46:4, pages 426-437.
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Sara Pegolo, Roberta Merlanti, Mery Giantin, Mauro Dacasto, Clara Montesissa & Francesca Capolongo. (2010) High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes. The Veterinary Journal 183:1, pages 81-88.
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Roberto Todeschini & Viviana Consonni. 2009. Molecular Descriptors for Chemoinformatics. Molecular Descriptors for Chemoinformatics 1 241 .
Ian R. Baxendale & Steven V. Ley. (2005) Formation of 4-Aminopyrimidines via the Trimerization of Nitriles Using Focused Microwave Heating. Journal of Combinatorial Chemistry 7:3, pages 483-489.
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H-J Xie, L Griskevicius, U Broberg, S Lundgren, S Carlens, L Meurling, C Paul, A Rane & M Hassan. (2003) Alteration of pharmacokinetics of cyclophosphamide and suppression of the cytochrome P450 genes by ciprofloxacin. Bone Marrow Transplantation 31:3, pages 197-203.
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M.H. Nelson, A.K. Birnbaum & R.P. Remmel. (2001) Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors. Epilepsy Research 44:1, pages 71-82.
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Roberto Todeschini & Viviana Consonni. 2000. Handbook of Molecular Descriptors. Handbook of Molecular Descriptors 524 667 .
J.K. Aronson. 1999. 273 284 .
W.M. Zweers‐Zeilmaker, G.J. Horbach & R.F. Witkamp. (2002) Effects of non steroidal anti‐inflammatory drugs and sulfonamides on hepatic cytochrome P4502C activity in vitro in goats and cattle . Journal of Veterinary Pharmacology and Therapeutics 21:2, pages 154-157.
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W.M Zweers-Zeilmaker, S Wildschut, R.F Witkamp & A.S.J.P.A.M Van Miert. (1997) The effect of sulfaphenazole and sulfadoxine on tolbutamide disposition in dwarf goats (Caprus hircus aegagrus). Research in Veterinary Science 63:3, pages 269-272.
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