Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activity in vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus).

W. M. ZWEERS-ZEILMAKER Faculty of Veterinary Medicine, Department of Veterinary Pharmacy, Pharmacology and Toxicology, and OE Research Institute of Toxicology, Utrecht University, Yalelaan 2, PO Box 80. 176, NL-3508 TD Utrecht, The Netherlands

G. J. HORBACH Faculty of Veterinary Medicine, Department of Veterinary Pharmacy, Pharmacology and Toxicology, and OE Research Institute of Toxicology, Utrecht University, Yalelaan 2, PO Box 80. 176, NL-3508 TD Utrecht, The Netherlands

R. F. WITKAMP* Faculty of Veterinary Medicine, Department of Veterinary Pharmacy, Pharmacology and Toxicology, and OE Research Institute of Toxicology, Utrecht University, Yalelaan 2, PO Box 80. 176, NL-3508 TD Utrecht, The Netherlands

Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activity in vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus).

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Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activity in vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus).

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