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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 4
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Research Article

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6substrate metabolism

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Pages 319-340 | Published online: 22 Sep 2008

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Dong Dong, Baojian Wu, Diana Chow & Ming Hu. (2012) Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metabolism Reviews 44:2, pages 192-208.
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Bo Wang, Li-Ping Yang, Xiao-Zhuang Zhang, Shui-Qing Huang, Mark Bartlam & Shu-Feng Zhou. (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metabolism Reviews 41:4, pages 573-643.
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Sean Ekins, Sergey Andreyev, Andy Ryabov, Eugene Kirillov, Eugene A Rakhmatulin, Andrej Bugrim & Tatiana Nikolskaya. (2005) Computational prediction of human drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 1:2, pages 303-324.
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David F. V. Lewis, Sandeep Modi & Maurice Dickins. (2002) Structure–activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metabolism Reviews 34:1-2, pages 69-82.
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David F. V. Lewis. (2002) Molecular modeling of human cytochrome P450–substrate interactions. Drug Metabolism Reviews 34:1-2, pages 55-67.
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David F.V. Lewis & Maurice Dickins. (2001) Quantitative Structure-Activity Relationships (QSARs) Within Series of Inhibitors for Mammalian Cytochromes P450 (CYPs). Journal of Enzyme Inhibition 16:4, pages 321-330.
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