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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 12
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Research Article

In vitro assessment of human cytochrome P450

Pages 1167-1202 | Published online: 22 Sep 2008

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Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu & James W. Paxton. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews 35:1, pages 35-98.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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David F.V. Lewis & Maurice Dickins. (2001) Quantitative Structure-Activity Relationships (QSARs) Within Series of Inhibitors for Mammalian Cytochromes P450 (CYPs). Journal of Enzyme Inhibition 16:4, pages 321-330.
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A. B. Renwick, G. Lavignette, P. D. Worboys, B. Williams, D. Surry, D. F. V. Lewis, R. J. Price, B. G. Lake & D. C. Evans. (2001) Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica 31:12, pages 861-878.
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R. J. Weaver. (2001) Assessment of drug-drug interactions: concepts and approaches. Xenobiotica 31:8-9, pages 499-538.
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M. A. M. WENKER, S. KEŽIĆ, A. C. MONSTER & F. A. DE WOLFF. (2001) Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity. Xenobiotica 31:2, pages 61-72.
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A. B. Renwick, D. Surry, R. J. Price, B. G. Lake & D. C. Evans. (2000) Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms. Xenobiotica 30:10, pages 955-969.
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Denis Projean, Bruno Baune, Robert Farinotti, Jean-Pierre Flinois, Philippe Beaune, Anne-Marie Taburet & Julie Ducharme. (2003) IN VITRO METABOLISM OF CHLOROQUINE: IDENTIFICATION OF CYP2C8, CYP3A4, AND CYP2D6 AS THE MAIN ISOFORMS CATALYZING N -DESETHYLCHLOROQUINE FORMATION . Drug Metabolism and Disposition 31:6, pages 748-754.
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M. Teresa Donato & Jos?? V. Castell. (2003) Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug Metabolism. Clinical Pharmacokinetics 42:2, pages 153-178.
Crossref
. (2002) Chapter 7: Biokinetics. Alternatives to Laboratory Animals 30:1_suppl, pages 55-70.
Crossref
Toshiro Niwa, Yumi Maekawa, Megumi Fujimoto, Kae KishimotoYoshiyasu YabusakiFumihide Ishibashi & Masanao Katagiri. (2002) Inhibition of Human Hepatic Cytochrome P450s and Steroidogenic CYP17 by Nonylphenol.. Biological and Pharmaceutical Bulletin 25:2, pages 235-238.
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Karthik Venkatakrishnan, Lisa L. von Moltke & David J. Greenblatt. (2013) Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models. The Journal of Clinical Pharmacology 41:11, pages 1149-1179.
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Annabelle Le Gal, Yvonne Dréano, Pier-Giovanni Gervasi & François Berthou. (2001) Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels. Toxicology Letters 124:1-3, pages 47-58.
Crossref
Peter Hlavica & David F. V. Lewis. (2008) Allosteric phenomena in cytochrome P450‐catalyzed monooxygenations. European Journal of Biochemistry 268:18, pages 4817-4832.
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David Lewis. 2001. Guide to Cytochromes P450. Guide to Cytochromes P450 164 210 .
A.David Rodrigues & Jiunn H Lin. (2001) Screening of drug candidates for their drug–drug interaction potential. Current Opinion in Chemical Biology 5:4, pages 396-401.
Crossref
A. David Rodrigues, Gregory A. Winchell & Michael R. Dobrinska. (2013) Use of In Vitro Drug Metabolism Data to Evaluate Metabolic Drug‐Drug Interactions in Man: The Need for Quantitative Databases. The Journal of Clinical Pharmacology 41:4, pages 368-373.
Crossref
Genevieve Ubeaud, Claus-Ditter Schiller, Fabrice Hurbin, Daniel Jaeck & Philippe Coassolo. (2001) Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers. European Journal of Drug Metabolism and Pharmacokinetics 26:1-2, pages 37-45.
Crossref
Thomas Thum & Jürgen Borlak. (2009) Cytochrome P450 mono‐oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat. British Journal of Pharmacology 130:8, pages 1745-1752.
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Bhama Parimoo & Paul E. Thomas. (2000) Epitope Mapping of Rat Cytochrome P450 2B1 Using Glutathione S-Transferase-2B1 Fusion Constructs. Archives of Biochemistry and Biophysics 380:1, pages 117-125.
Crossref
Ronald E. White. (2000) High-Throughput Screening in Drug Metabolism and Pharmacokinetic Support of Drug Discovery. Annual Review of Pharmacology and Toxicology 40:1, pages 133-157.
Crossref
Ray Bakhtiar & Randall W. Nelson. (2000) Electrospray ionization and matrix-assisted laser desorption ionization mass spectrometry. Biochemical Pharmacology 59:8, pages 891-905.
Crossref
Thomas Thum & Jürgen Borlak. (2000) Gene expression in distinct regions of the heart. The Lancet 355:9208, pages 979-983.
Crossref
Geoffrey T. Tucker. (2000) Advances in Understanding Drug Metabolism and Its Contribution to Variability in Patient Response. Therapeutic Drug Monitoring 22:1, pages 110-113.
Crossref
Pavel Souček. (1999) Expression of Cytochrome P450 2A6 in Escherichia coli: Purification, Spectral and Catalytic Characterization, and Preparation of Polyclonal Antibodies. Archives of Biochemistry and Biophysics 370:2, pages 190-200.
Crossref

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