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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 9
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Research Article

Effects of propofol on human hepatic microsomal cytochrome P450 activities

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Pages 845-853 | Published online: 22 Sep 2008

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Read on this site (7)

Marycarmen Cruz-Hurtado, Ma de Lourdes López-González, Victor Mondragón & Adolfo Sierra-Santoyo. (2019) In vitro phase I metabolism of vinclozolin by human liver microsomes. Xenobiotica 49:8, pages 895-904.
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A. D. McCormick, D. L. Slamon, E. M. Lenz, P. J. Phillips, C. D. King, D. Mckillop & D. W. Roberts. (2007) metabolism of a triclyclic alkaloid (M445526) in human liver microsomes and hepatocytes. Xenobiotica 37:9, pages 972-985.
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N. Murayama, M. Minoshima, M. Shimizu, F. P. Guengerich & H. Yamazaki. (2007) Involvement of human cytochrome P450 2B6 in the - and 4-hydroxylation of the anesthetic agent propofol. Xenobiotica 37:7, pages 717-724.
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D. Mckillop, A. D. Mccormick, G. S. Miles, P. J. Phillips, K. J. Pickup, N. Bushby & M. Hutchison. (2004) In vitro metabolism of gefitinib in human liver microsomes. Xenobiotica 34:11-12, pages 983-1000.
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Sherry K. Cox, Tina Hamner & Joe Bartges. (2003) Determination of Acetaminophen and Phenacetin in Porcine Microsomal Samples. Journal of Liquid Chromatography & Related Technologies 26:6, pages 925-935.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (34)

Katharina Haller, Sandra Doß & Martin Sauer. (2024) In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs. Current Issues in Molecular Biology 46:4, pages 3022-3038.
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Jaap Vuyk. 2017. Total Intravenous Anesthesia and Target Controlled Infusions. Total Intravenous Anesthesia and Target Controlled Infusions 313 325 .
Sónia P. Campos, Maria de Lurdes Pinto, Gabriela Gomes, Paula Guedes de Pinho, Joaquim A. Monteiro, Luis M. Félix, Paula S. Branco, Luísa M. Ferreira & Luís M. Antunes. (2016) Expression of CYP1A1 and CYP1A2 in the liver and kidney of rabbits after prolonged infusion of propofol. Experimental and Toxicologic Pathology 68:9, pages 521-531.
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Shanshan Cao, Yuwen Li, Lu Wang, Jia Cui, Na Jia, Ruili Li, Chao Zhao, Chao Wang, Yin Wu & Aidong Wen. (2016) Synergistic analgesic effect of propofol–alfentanil combination through detecting the inhibition of cAMP signal pathway. Journal of Pharmacy and Pharmacology 68:9, pages 1170-1176.
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Manisha Bhateria, Rachumallu Ramakrishna, Santosh Kumar Puttrevu, Anil K. Saxena & Rabi Sankar Bhatta. (2016) Enantioselective inhibition of Cytochrome P450-mediated drug metabolism by a novel antithrombotic agent, S002-333: Major effect on CYP2B6. Chemico-Biological Interactions 256, pages 257-265.
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Ted Whittem, Thierry Beths & Sébastien H. Bauquier. 2015. Veterinary Anesthesia and Analgesia. Veterinary Anesthesia and Analgesia 145 177 .
Jason L. Russell, Henry A. Spiller & Daniel D. Baker. (2015) Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion. Case Reports in Medicine 2015, pages 1-4.
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Yoanna Skrobik & Michel Laverdiere. (2013) Why Candida Sepsis Should Matter to ICU Physicians. Critical Care Clinics 29:4, pages 853-864.
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Valerie J Page, E Wesley Ely, Simon Gates, Xiao Bei Zhao, Timothy Alce, Ayumi Shintani, Jim Jackson, Gavin D Perkins & Daniel F McAuley. (2013) Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. The Lancet Respiratory Medicine 1:7, pages 515-523.
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Kenji Momo, Masato Homma, Sayaka Matsumoto, Tadanori Sasaki & Yukinao Kohda. (2013) Clinical Survey of Tizanidine-induced Adverse Effects<br/>—Impact of Concomitant Drugs Providing Cytochrome P450 1A2 Modification—チザニジンの副作用に関する実態調査<br/>—Cytochrome P450 1A2に影響する薬剤の併用との関連—. YAKUGAKU ZASSHI 133:2, pages 275-281.
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Ilaria Campesi, Marco Fois & Flavia Franconi. 2012. Sex and Gender Differences in Pharmacology. Sex and Gender Differences in Pharmacology 265 278 .
Siamak Cyrus Khojasteh, Saileta Prabhu, Jane R. Kenny, Jason S. Halladay & Anthony Y. H. Lu. (2011) Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. European Journal of Drug Metabolism and Pharmacokinetics 36:1, pages 1-16.
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Fumiyasu Kansaku, Toshio Kumai, Kuniharu Sasaki, Makito Yokozuka, Makiko Shimizu, Tadashi Tateda, Norie Murayama, Shinichi Kobayashi & Hiroshi Yamazaki. (2011) Individual Differences in Pharmacokinetics and Pharmacodynamics of Anesthetic Agent Propofol with Regard to CYP2B6 and UGT1A9 Genotype and Patient Age. Drug Metabolism and Pharmacokinetics 26:5, pages 532-537.
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Toshiyuki Takanohashi, Satoru Kubo, Akira Nakayama, Ryuichi Mihara & Masahiro Hayashi. (2010) Inhibition of human liver microsomal CYP by nateglinide. Journal of Pharmacy and Pharmacology 62:5, pages 592-597.
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L. Richert, G. Tuschl, C. Abadie, N. Blanchard, D. Pekthong, G. Mantion, J.-C. Weber & S.O. Mueller. (2009) Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicology and Applied Pharmacology 235:1, pages 86-96.
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Franklin D. Westhout, Michael G. Muhonen & Chiedozie I. Nwagwu. (2007) Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Journal of Neurosurgery: Pediatrics 106:2, pages 139-142.
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Hiroshi Yamazaki, Makiko Shimizu, Takashi Nagashima, Masaki Minoshima & Norie Murayama. (2006) Rat Cytochrome P450 2C11 in Liver Microsomes Involved in Oxidation of Anesthetic Agent Propofol and Deactivated by Prior Treatment with Propofol. Drug Metabolism and Disposition 34:11, pages 1803-1805.
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Yong Liu, Jiang-Wei Zhang, Wei Li, Hong Ma, Jie Sun, Mai-Cun Deng & Ling Yang. (2006) Ginsenoside Metabolites, Rather Than Naturally Occurring Ginsenosides, Lead to Inhibition of Human Cytochrome P450 Enzymes. Toxicological Sciences 91:2, pages 356-364.
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Trevor Green, Alison Toghill, Robert Lee, Felix Waechter, Edgar Weber, Richard Peffer, James Noakes & Mervyn Robinson. (2005) Thiamethoxam Induced Mouse Liver Tumors and Their Relevance to Humans. Toxicological Sciences 86:1, pages 48-55.
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Helen C Swaisland, Malcolm Ranson, Robert P Smith, Joanna Leadbetter, Alison Laight, David McKillop & Martin J Wild. (2005) Pharmacokinetic Drug Interactions of Gefitinib with Rifampicin, Itraconazole and Metoprolol. Clinical Pharmacokinetics 44:10, pages 1067-1081.
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Matthias Unger & Andreas Frank. (2004) Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Communications in Mass Spectrometry 18:19, pages 2273-2281.
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Einosuke Tanaka, Yui Takano, Shinichi Inomata, Hidenori Toyooka & Katsuya Honda. (2004) Premedication medicines do not cause drug metabolic interaction with propofol using human liver microsomes in vitro. European Journal of Clinical Pharmacology 60:8, pages 565-568.
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Hideko Kanazawa, Akiko Okada, Eri Igarashi, Megumu Higaki, Takako Miyabe, Tadashi Sano & Ryouhei Nishimura. (2004) Determination of midazolam and its metabolite as a probe for cytochrome P450 3A4 phenotype by liquid chromatography–mass spectrometry. Journal of Chromatography A 1031:1-2, pages 213-218.
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Bart-Jan Lichtenbelt, Martijn Mertens & Jaap Vuyk. (2004) Strategies to Optimise Propofol-Opioid Anaesthesia. Clinical Pharmacokinetics 43:9, pages 577-593.
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Shahrzad Dilmaghanian, John G. Gerber, Scott G. Filler, Angela Sanchez & Joseph Gal. (2003) Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates. Chirality 16:2, pages 79-85.
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Li-Qun Yang. (2003) Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes. World Journal of Gastroenterology 9:9, pages 1959.
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Samuel A TestinoJr.Jr. & Gabor Patonay. (2003) High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 30:5, pages 1459-1467.
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Corinne Lejus, Alain Fautrel, Yannick Mallédant & André Guillouzo. (2002) Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochemical Pharmacology 64:7, pages 1151-1156.
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V. Garib, B. Niggemann, K S. Zänker, L. Brandt & B. S. Kubens. (2002) Influence of non‐volatile anesthetics on the migration behavior of the human breast cancer cell line 
MDA‐MB‐468. Acta Anaesthesiologica Scandinavica 46:7, pages 836-844.
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J. L. Palmer. (2016) Concluding remarks— Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine?. Journal of Psychopharmacology 14:2, pages 187-188.
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S. C. Stanford & B. J. Stanford. (2016) Reply to J. L. Palmer — Postoperative delirium indicating an adverse drug interaction involving the selective serotonin reuptake inhibitor, paroxetine?. Journal of Psychopharmacology 14:2, pages 186-187.
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Sandra CoeckeVera RogiersMartin BaylissJosé CastellJohannes DoehmerGérard FabreJeffrey FryArmin Kern & Carl Westmoreland. (2019) The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status. Alternatives to Laboratory Animals 27:4, pages 579-638.
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