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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 7
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Research Article

The CYP2 family: models, mutants and interactions

Pages 617-661 | Published online: 22 Sep 2008

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Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto, Takeshi Akiyoshi & Hisakazu Ohtani. (2023) The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro. Xenobiotica 53:5, pages 357-365.
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Qiaoli Wang, Xiaotong Han, Jian Li, Xinghui Gao, Yan Wang, Mingzhou Liu, Guicheng Dong & Jiang Yue. (2015) Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine. Xenobiotica 45:4, pages 335-344.
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Kathleen R. Tucker, David Jacobs, Jacob Manjarrez & Gilbert H. John. (2006) The metabolism of phenobarbital, a drug used for epilepsy, by intestinal flora, Bifidobacterium adolescentis and Bifidobacterium bifidum. Microbial Ecology in Health and Disease 18:1, pages 32-37.
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Petr Hodek, Lucie Bořek-Dohalská, Bruno Sopko, Miroslav Šulc, Stanislav Smrček, Jiří Hudeček, Josef Janků & Marie Stiborová. (2005) Structural requirements for inhibitors of cytochromes P450 2B: Assessment of the enzyme interaction with diamondoids. Journal of Enzyme Inhibition and Medicinal Chemistry 20:1, pages 25-33.
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S. Marini, E. Grasso, V. Longo, P. Puccini, B. Riccardi & P. Giovanni Gervasi. (2003) 4-Biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human. Xenobiotica 33:1, pages 1-11.
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David F. V. Lewis. (2002) Molecular modeling of human cytochrome P450–substrate interactions. Drug Metabolism Reviews 34:1-2, pages 55-67.
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N. Hagen, A. K. Olsen, J. V. Andersen, J. Tjørnelund & S. H. Hansen. (2002) Characterization of mixtures of recombinant human cytochrome P450s as a screening model for metabolic stability in drug discovery. Xenobiotica 32:9, pages 749-759.
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K. Taguchi, T. Konishi, H. Nishikawa & S. Kitamura. (1999) Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid. Xenobiotica 29:9, pages 899-907.
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Articles from other publishers (64)

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Masaki Kumondai, Akio Ito, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, Tomoki Nakayoshi, Akifumi Oda, Shu Tadaka, Kengo Kinoshita, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa & Masahiro Hiratsuka. (2021) Functional Assessment of 12 Rare Allelic CYP2C9 Variants Identified in a Population of 4773 Japanese Individuals. Journal of Personalized Medicine 11:2, pages 94.
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Junjun Wang, Ting Zhai & Yong Chen. (2018) Effects of Honokiol on CYP450 Activity and Transporter mRNA Expression in Type 2 Diabetic Rats. International Journal of Molecular Sciences 19:3, pages 815.
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Masaki Kumondai, Hiroki Hosono, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa & Masahiro Hiratsuka. (2018) Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation. Drug Metabolism and Pharmacokinetics 33:1, pages 82-89.
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M Takahashi, T Saito, M Ito, C Tsukada, Y Katono, H Hosono, M Maekawa, M Shimada, N Mano, A Oda, N Hirasawa & M Hiratsuka. (2014) Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation. The Pharmacogenomics Journal 15:1, pages 26-32.
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Qi Chen & Dongqing Wei. 2015. Advance in Structural Bioinformatics. Advance in Structural Bioinformatics 341 351 .
R T Miller, S Miksys, E Hoffmann & R F Tyndale. (2014) Ethanol self‐administration and nicotine treatment increase brain levels of CYP 2 D in A frican green monkeys . British Journal of Pharmacology 171:12, pages 3077-3088.
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Y Niinuma, T Saito, M Takahashi, C Tsukada, Mi Ito, N Hirasawa & M Hiratsuka. (2013) Functional characterization of 32 CYP2C9 allelic variants. The Pharmacogenomics Journal 14:2, pages 107-114.
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