Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 6
Submit an article Journal homepage
139
Views
73
CrossRef citations to date
0
Altmetric
Research Article

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

T. NIWA Division of Natural Science, Osaka Kyoiku University, 4 Asahiga-oka, Kashiwara, Osaka 582, Japan OE Biotechnology Laboratory, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan Clinical Laboratories, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan Department of Pediatric, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
,
Y. YABUSAKI Division of Natural Science, Osaka Kyoiku University, 4 Asahiga-oka, Kashiwara, Osaka 582, Japan OE Biotechnology Laboratory, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan Clinical Laboratories, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan Department of Pediatric, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
,
K. HONMA Division of Natural Science, Osaka Kyoiku University, 4 Asahiga-oka, Kashiwara, Osaka 582, Japan OE Biotechnology Laboratory, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan Clinical Laboratories, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan Department of Pediatric, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
,
N. MATSUO Division of Natural Science, Osaka Kyoiku University, 4 Asahiga-oka, Kashiwara, Osaka 582, Japan OE Biotechnology Laboratory, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan Clinical Laboratories, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan Department of Pediatric, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
,
K. TATSUTA Division of Natural Science, Osaka Kyoiku University, 4 Asahiga-oka, Kashiwara, Osaka 582, Japan OE Biotechnology Laboratory, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan Clinical Laboratories, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan Department of Pediatric, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
,
F. ISHIBASHI Division of Natural Science, Osaka Kyoiku University, 4 Asahiga-oka, Kashiwara, Osaka 582, Japan OE Biotechnology Laboratory, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan Clinical Laboratories, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan Department of Pediatric, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
&
M. KATAGIRI Division of Natural Science, Osaka Kyoiku University, 4 Asahiga-oka, Kashiwara, Osaka 582, Japan OE Biotechnology Laboratory, Sumitomo Chemical Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan Clinical Laboratories, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan Department of Pediatric, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
 show all
Pages 539-547 | Published online: 22 Sep 2008

Citations (73)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Wojciech Kuban & Władysława Anna Daniel. (2021) Cytochrome P450 expression and regulation in the brain. Drug Metabolism Reviews 53:1, pages 1-29.
Read now
Sara K. Quinney, Tara Benjamin, Xiaomei Zheng & Avinash S. Patil. (2017) Characterization of Maternal and Fetal CYP3A-Mediated Progesterone Metabolism. Fetal and Pediatric Pathology 36:5, pages 400-411.
Read now
Francesca Toselli, Peter R. Dodd & Elizabeth M. J. Gillam. (2016) Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs. Drug Metabolism Reviews 48:3, pages 379-404.
Read now
Toshiro Niwa, Norie Murayama, Yurie Imagawa & Hiroshi Yamazaki. (2015) Regioselective hydroxylation of steroid hormones by human cytochromes P450. Drug Metabolism Reviews 47:2, pages 89-110.
Read now
Bo Wang, Li-Ping Yang, Xiao-Zhuang Zhang, Shui-Qing Huang, Mark Bartlam & Shu-Feng Zhou. (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metabolism Reviews 41:4, pages 573-643.
Read now
Yan-Yan Zhang & Ling Yang. (2009) Interactions between human cytochrome P450 enzymes and steroids: physiological and pharmacological implications. Expert Opinion on Drug Metabolism & Toxicology 5:6, pages 621-629.
Read now
Xiaochao Ma, Jeffrey R Idle & Frank J Gonzalez. (2008) The pregnane X receptor: from bench to bedside. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 895-908.
Read now
T. Niwa, T. Shiraga, S. Yamasaki, K. Ishibashi, Y. Ohno & A. Kagayama. (2003) In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes. Xenobiotica 33:7, pages 717-729.
Read now
Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
Read now
T. NIWA. (1999) Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica 29:2, pages 187-193.
Read now

Articles from other publishers (63)

Samiksha Kukal, Sarita Thakran, Neha Kanojia, Saroj Yadav, Manish Kumar Mishra, Debleena Guin, Pooja Singh & Ritushree Kukreti. (2023) Genic-intergenic polymorphisms of CYP1A genes and their clinical impact. Gene 857, pages 147171.
Crossref
Liu Liu, Hongyang Cui, Yixuan Huang, Hao Yan, Yulan Zhou & Yi Wan. (2023) Molecular docking and in vitro evaluations reveal the role of human cytochrome P450 3A4 in the cross-coupling metabolism of phenolic xenobiotics. Environmental Research 220, pages 115256.
Crossref
Solène Marie, Kayla L. Frost, Raymond K. Hau, Lucy Martinez-Guerrero, Jailyn M. Izu, Cassandra M. Myers, Stephen H. Wright & Nathan J. Cherrington. (2023) Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients. Acta Pharmaceutica Sinica B 13:1, pages 1-28.
Crossref
Yousef Alizadeh, Mitra Akbari, Soheil Soltanipour, Reza Soltani Moghadam, Abdolreza Medghalchi, Maryam Dourandeesh & Halleh Alizadeh. (2022) Using oral Rifampin to treat acute central serous Chorioretinopathy: a randomized placebo-controlled clinical trial ‎. Journal Of Advanced Pharmacy Education And Research 12:2, pages 11-18.
Crossref
Owain Roberts, Hannah Kinvig, Andrew Owen, Mohammed Lamorde, Marco Siccardi & Kimberly K. Scarsi. (2021) In vitro assessment of the potential for dolutegravir to affect hepatic clearance of levonorgestrel . HIV Medicine 22:10, pages 898-906.
Crossref
Yasushi Yamazoe & Masahiro Tohkin. (2021) Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template. Drug Metabolism and Pharmacokinetics 38, pages 100357.
Crossref
Nuno R. Coelho, Clara Matos, António B. Pimpão, M. João Correia, Catarina O. Sequeira, Judit Morello, Sofia A. Pereira & Emília C. Monteiro. (2021) AHR canonical pathway: in vivo findings to support novel antihypertensive strategies. Pharmacological Research 165, pages 105407.
Crossref
Slobodan P. Rendic & F. Peter Guengerich. (2021) Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology 95:2, pages 395-472.
Crossref
Silvia Beato, Francisco Javier Toledo-Solís & Ignacio Fernández. (2020) Vitamin K in Vertebrates’ Reproduction: Further Puzzling Pieces of Evidence from Teleost Fish Species. Biomolecules 10:9, pages 1303.
Crossref
Derly Constanza Escobar-Wilches, Arianna Ventura-Bahena, Ma. de Lourdes López-González, Luisa Torres-Sánchez, Mario Figueroa & Adolfo Sierra-Santoyo. (2020) Analysis of testosterone-hydroxylated metabolites in human urine by ultra high performance liquid chromatography-Mass Spectrometry. Analytical Biochemistry 597, pages 113670.
Crossref
Yasushi Yamazoe & Kouichi Yoshinari. (2020) Prediction of regioselectivity and preferred order of CYP1A1-mediated metabolism: Solving the interaction of human and rat CYP1A1 forms with ligands on the template system. Drug Metabolism and Pharmacokinetics 35:1, pages 165-185.
Crossref
Jian Lu, Xuyang Shang, Weiguo Zhong, Yuan Xu, Rong Shi & Xin Wang. (2020) New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases. Acta Pharmaceutica Sinica B 10:1, pages 91-104.
Crossref
Takahiro Goto, Masahiro Tohkin & Yasushi Yamazoe. (2019) Solving the interactions of steroidal ligands with CYP3A4 using a grid-base template system. Drug Metabolism and Pharmacokinetics 34:6, pages 351-364.
Crossref
Lina Schiffer, Lise Barnard, Elizabeth S. Baranowski, Lorna C. Gilligan, Angela E. Taylor, Wiebke Arlt, Cedric H.L. Shackleton & Karl-Heinz Storbeck. (2019) Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. The Journal of Steroid Biochemistry and Molecular Biology 194, pages 105439.
Crossref
Luz M. Canet, Jose M. Sánchez-Maldonado, Rafael Cáliz, Ana Rodríguez-Ramos, Carmen B. Lupiañez, Helena Canhão, Manuel Martínez-Bueno, Alejandro Escudero, Juana Segura-Catena, Signe B Sorensen, Merete L Hetland, María José Soto-Pino, Miguel A. Ferrer, Antonio García, Bente Glintborg, Ileana Filipescu, Eva Pérez-Pampin, Alfonso González-Utrilla, Miguel Ángel López Nevot, Pablo Conesa-Zamora, Alfons den Broeder, Salvatore De Vita, Sven Erik Hobe Jacobsen, Eduardo Collantes-Estevez, Luca Quartuccio, Federico Canzian, João E. Fonseca, Marieke J. H. Coenen, Vibeke Andersen & Juan Sainz. (2018) Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients. The Pharmacogenomics Journal 19:1, pages 83-96.
Crossref
Heli Routti, Bjørn M. Jenssen & Sabrina Tartu. 2018. Marine Mammal Ecotoxicology. Marine Mammal Ecotoxicology 345 380 .
Francis K. Yoshimoto, Eric Gonzalez, Richard J. Auchus & F. Peter Guengerich. (2016) Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1. Journal of Biological Chemistry 291:33, pages 17143-17164.
Crossref
Shufeng Zhou. 2016. Cytochrome P450 2D6. Cytochrome P450 2D6 341 414 .
Elham Badavi, Babak Safavi, Amir Jalali, Ghazaleh Mohammadzadeh Shahriary, Javad Mohammadi-Asl & Javad Babaei. (2015) Association of CYP3A4 and CYP3A5 polymorphisms with Iranian breast cancer patients. Egyptian Journal of Medical Human Genetics 16:3, pages 219-225.
Crossref
F. Peter Guengerich. 2015. Cytochrome P450. Cytochrome P450 523 785 .
Esau Floriano-Sanchez, Noemi Cardenas Rodriguez, Cindy Bandala, Elvia Coballase-Urrutia & Jaime Lopez-Cruz. (2014) CYP3A4 Expression in Breast Cancer and its Association with Risk Factors in Mexican Women. Asian Pacific Journal of Cancer Prevention 15:8, pages 3805-3809.
Crossref
Xiaoshuang Wang, Jie Li, Guicheng Dong & Jiang Yue. (2014) The endogenous substrates of brain CYP2D. European Journal of Pharmacology 724, pages 211-218.
Crossref
Declan Doherty, Scarlett Anne Dvorkin, Edna Patricia Rodriguez & Paul Daniel Thompson. (2014) Vitamin D receptor agonist EB1089 is a potent regulator of prostatic “intracrine” metabolism. The Prostate 74:3, pages 273-285.
Crossref
Pengyu Sun & Yunhua Wu. (2013) An amperometric biosensor based on human cytochrome P450 2C9 in polyacrylamide hydrogel films for bisphenol A determination. Sensors and Actuators B: Chemical 178, pages 113-118.
Crossref
Sofia Christakoudi, David A. Cowan & Norman F. Taylor. (2012) Steroids excreted in urine by neonates with 21-hydroxylase deficiency. 3. Characterization, using GC–MS and GC–MS/MS, of androstanes and androstenes. Steroids 77:13, pages 1487-1501.
Crossref
Slobodan Rendic & F. Peter Guengerich. (2012) Contributions of Human Enzymes in Carcinogen Metabolism. Chemical Research in Toxicology 25:7, pages 1316-1383.
Crossref
Michael Murray. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 517 542 .
Chandra ShekharYadav, Minu Bajpai, Vivek Kumar, Rafat Sultana Ahmed, Piyush Gupta & Basu Dev Banerjee. (2011) Polymorphism in CYP1A1, GSTMI, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias . Human & Experimental Toxicology 30:10, pages 1464-1474.
Crossref
Chibueze A. Ihunnah, Mengxi Jiang & Wen Xie. (2011) Nuclear receptor PXR, transcriptional circuits and metabolic relevance. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1812:8, pages 956-963.
Crossref
Karl-Heinz Storbeck, Pieter Swart, Donita Africander, Riaan Conradie, Renate Louw & Amanda C. Swart. (2011) 16α-Hydroxyprogesterone: Origin, biosynthesis and receptor interaction. Molecular and Cellular Endocrinology 336:1-2, pages 92-101.
Crossref
Landry K. Kamdem, David A. Flockhart & Zeruesenay Desta. (2011) In Vitro Cytochrome P450-Mediated Metabolism of Exemestane. Drug Metabolism and Disposition 39:1, pages 98-105.
Crossref
Sofia Christakoudi, David A. Cowan & Norman F. Taylor. (2010) Steroids excreted in urine by neonates with 21-hydroxylase deficiency: Characterization, using GC–MS and GC–MS/MS, of the D-ring and side chain structure of pregnanes and pregnenes. Steroids 75:1, pages 34-52.
Crossref
Patrik Rydberg, Poongavanam Vasanthanathan, Chris Oostenbrink & Lars Olsen. (2009) Fast Prediction of Cytochrome P450 Mediated Drug Metabolism. ChemMedChem 4:12, pages 2070-2079.
Crossref
Alessandra di Masi, Elisabetta De Marinis, Paolo Ascenzi & Maria Marino. (2009) Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects. Molecular Aspects of Medicine 30:5, pages 297-343.
Crossref
Helena Hedström, Marie Bixo, Sigrid Nyberg, Olav Spigset, Elisabeth Zingmark & Torbjörn Bäckström. (2008) Studies of pharmacokinetic and pharmacodynamic properties of isoallopregnanolone in healthy women. Psychopharmacology 203:1, pages 85-98.
Crossref
Masakatsu Kotsuma, Hiroyuki Hanzawa, Yoriko Iwata, Kenji Takahashi & Taro Tokui. (2008) Novel Binding Mode of the Acidic CYP2D6 Substrates Pactimibe and Its Metabolite R-125528. Drug Metabolism and Disposition 36:9, pages 1938-1943.
Crossref
Toshiro Niwa, Kazushi Okada, Toyoko Hiroi, Susumu Imaoka, Shizuo Narimatsu & Yoshihiko Funae. (2008) Effect of Psychotropic Drugs on the 21-Hydroxylation of Neurosteroids, Progesterone and Allopregnanolone, Catalyzed by Rat CYP2D4 and Human CYP2D6 in the Brain. Biological and Pharmaceutical Bulletin 31:3, pages 348-351.
Crossref
Eriko Higashi, Miki Nakajima, Miki Katoh, Shogo Tokudome & Tsuyoshi Yokoi. (2007) Inhibitory Effects of Neurotransmitters and Steroids on Human CYP2A6. Drug Metabolism and Disposition 35:4, pages 508-514.
Crossref
Irina A. Pikuleva. (2006) Cytochrome P450s and cholesterol homeostasis. Pharmacology & Therapeutics 112:3, pages 761-773.
Crossref
S. Chalbot & R. Morfin. (2006) Dehydroepiandrosterone Metabolites and their Interactions in Humans. Drug Metabolism and Drug Interactions 22:1, pages 1-24.
Crossref
Jennifer L. Donovan, C. Lindsay DeVane, John G. Lewis, Jun-Sheng Wang, Ying Ruan, Kenneth D. Chavin & John S. Markowitz. (2005) Effects of St John's wort (Hypericum perforatum L.) extract on plasma androgen concentrations in healthy men and women: a pilot study. Phytotherapy Research 19:10, pages 901-906.
Crossref
Sonia Chalbot & Robert Morfin. (2005) HUMAN LIVER S9 FRACTIONS: METABOLISM OF DEHYDROEPIANDROSTERONE, EPIANDROSTERONE, AND RELATED 7-HYDROXYLATED DERIVATIVES. Drug Metabolism and Disposition 33:4, pages 563-569.
Crossref
N. Kurahashi, F. Sata, S. Kasai, T. Shibata, K. Moriya, H. Yamada, H. Kakizaki, H. Minakami, K. Nonomura & R. Kishi. (2005) Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias. MHR: Basic science of reproductive medicine 11:2, pages 93-98.
Crossref
Sakiko FUJIIKaoru YABEMasatoshi FURUKAWAMariko HIRATAMasao KIGUCHITsuguo IKKA. (2005) A TWO-GENERATION REPRODUCTIVE TOXICITY STUDY OF DIETHYL PHTHALATE (DEP) IN RATS. The Journal of Toxicological Sciences 30:Special, pages S97-116.
Crossref
F. Peter Guengerich. 2005. Cytochrome P450. Cytochrome P450 377 530 .
Toshiro Niwa, Toyoko Hiroi, Daisuke Tsuzuki, Shigeo Yamamoto, Shizuo Narimatsu, Tsuyoshi Fukuda, Junichi Azuma & Yoshihiko Funae. (2004) Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Molecular Brain Research 129:1-2, pages 117-123.
Crossref
Jyoti Kalbag, Cheryl Elder, Graham Scott, Yibin Wang, Slavica Milosavljev, Philipp Leese, Jacque Caldwell & Christiane Rordorf. (2013) Concomitant Administration of Lumiracoxib and a Triphasic Oral Contraceptive Does Not Affect Contraceptive Activity or Pharmacokinetic Profile. The Journal of Clinical Pharmacology 44:6, pages 646-654.
Crossref
Mark J.I. Paine, Lesley A. McLaughlin, Jack U. Flanagan, Carol A. Kemp, Michael J. Sutcliffe, Gordon C.K. Roberts & C. Roland Wolf. (2003) Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6. Journal of Biological Chemistry 278:6, pages 4021-4027.
Crossref
M. Teresa Donato & Jos?? V. Castell. (2003) Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug Metabolism. Clinical Pharmacokinetics 42:2, pages 153-178.
Crossref
Yoshihiko Funae, Wataru Kishimoto, Toshio Cho, Toshiro Niwa & Toyoko Hiroi. (2003) CYP2D in the Brain. Drug Metabolism and Pharmacokinetics 18:6, pages 337-349.
Crossref
Toshiro Niwa, Akira Kageyama, Kae Kishimoto, Yoshiyasu Yabusaki, Fumihide Ishibashi & Masanao Katagiri. (2002) Amino Acid Residues Affecting the Activities of Human Cytochrome P450 2C9 and 2C19. Drug Metabolism and Disposition 30:8, pages 931-936.
Crossref
Firoozeh S. Salek, Kristin L. Bigos & Patricia Dowley Kroboth. (2013) The Influence of Hormones and Pharmaceutical Agents on DHEA and DHEA‐S Concentrations: A Review of Clinical Studies. The Journal of Clinical Pharmacology 42:3, pages 247-266.
Crossref
F. P. Guengerich. (2002) Rate-Limiting Steps in Cytochrome P450 Catalysis. Biological Chemistry 383:10.
Crossref
Toshiro Niwa, Yumi Maekawa, Megumi Fujimoto, Kae KishimotoYoshiyasu YabusakiFumihide Ishibashi & Masanao Katagiri. (2002) Inhibition of Human Hepatic Cytochrome P450s and Steroidogenic CYP17 by Nonylphenol.. Biological and Pharmaceutical Bulletin 25:2, pages 235-238.
Crossref
Imad H. Hanna, Joel A. Krauser, Hongliang Cai, Mi-Sook Kim & F. Peter Guengerich. (2001) Diversity in Mechanisms of Substrate Oxidation by Cytochrome P450 2D6. Journal of Biological Chemistry 276:43, pages 39553-39561.
Crossref
Imad H. Hanna, Mi-Sook Kim & F.Peter Guengerich. (2001) Heterologous Expression of Cytochrome P450 2D6 Mutants, Electron Transfer, and Catalysis of Bufuralol Hydroxylation: The Role of Aspartate 301 in Structural Integrity. Archives of Biochemistry and Biophysics 393:2, pages 255-261.
Crossref
Toshiro NIWA, Megumi FUJIMOTO, Kae KISHIMOTOYoshiyasu YABUSAKIFumihide ISHIBASHI & Masanao KATAGIRI. (2001) Metabolism and Interaction of Bisphenol A in Human Hepatic Cytochrome P450 and Steroidogenic CYP17.. Biological and Pharmaceutical Bulletin 24:9, pages 1064-1067.
Crossref
Di Wu, Xiaobin Wang, Dafang Chen, Tianhua Niu, Jiatong Ni, Xue Liu & Xiping Xu. (2000) Metabolic Gene Polymorphisms and Risk of Dysmenorrhea. Epidemiology 11:6, pages 648-653.
Crossref
Dieter Schwarz, Pyotr Kisselev, Wolf-Hagen Schunck, Alexey Chernogolov, Werner Boidol, Ingolf Cascorbi & Ivar Roots. (2000) Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics 10:6, pages 519-530.
Crossref
Reginald F. Frye, Patricia D. Kroboth, Frank J. Kroboth, Roslyn A. Stone, Maggie Folan, Firoozeh S. Salek, Bruce G. Pollock, Ana M. Linares & Charles Hakala. (2000) Sex Differences in the Pharmacokinetics of Dehydroepiandrosterone (DHEA) after Single- and Multiple-Dose Administration in Healthy Older Adults. The Journal of Clinical Pharmacology 40:6, pages 596-605.
Crossref
Slobodan Rendic, Eckhard Nolteernsting & Wilhelm Schänzer. (1999) Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Journal of Chromatography B: Biomedical Sciences and Applications 735:1, pages 73-83.
Crossref
Zufan Araya & Kjell Wikvall. (1999) 6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1438:1, pages 47-54.
Crossref
Catrin Furster & Kjell Wikvall. (1999) Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5β-cholestane-3α,7α,12α-triol in human liver microsomes. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1437:1, pages 46-52.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.