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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 9
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Research Article

Activation of phenacetin O-deethylase activity by α-naphthoflavone in human liver microsomes

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Pages 885-898 | Published online: 22 Sep 2008

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Kevin A. Ford, Gregory Ryslik, Jasleen Sodhi, Jason Halladay, Dolo Diaz, Donna Dambach & Melisa Masuda. (2015) Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications. Drug Metabolism Reviews 47:3, pages 291-319.
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Sherry K. Cox, Tina Hamner & Joe Bartges. (2003) Determination of Acetaminophen and Phenacetin in Porcine Microsomal Samples. Journal of Liquid Chromatography & Related Technologies 26:6, pages 925-935.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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S. Ozawa, K. Ohta, A. Miyajima, H. Kurebayashi, M. Sunouchi, M. Shimizu, N. Murayama, Y. Matsumoto, M. Fukuoka & Y. Ohno. (2000) Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1. Xenobiotica 30:10, pages 1005-1017.
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Articles from other publishers (13)

Paula Ichinose, María Victoria Miró, Karen Larsen, Adrián Lifschitz & Guillermo Virkel. (2024) Unravelling drug-drug interactions in pigs: Induction of hepatic cytochrome P450 1A (CYP1A) metabolism after the in-feed medication with the anthelmintic fenbendazole. Research in Veterinary Science 167, pages 105113.
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Elena V. Sineva, Jessica A. O. Rumfeldt, James R. Halpert & Dmitri R. Davydov. (2013) A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET). PLoS ONE 8:12, pages e83898.
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Dmitri R. DavydovNadezhda Y. DavydovaElena V. SinevaIrina KufarevaJames R. Halpert. (2013) Pivotal role of P450–P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone. Biochemical Journal 453:2, pages 219-230.
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Lucie Bořek-Dohalská & Marie Stiborová. (2010) Cytochrome P450 3A activities and their modulation by α-naphthoflavone in vitro are dictated by the efficiencies of model experimental systems. Collection of Czechoslovak Chemical Communications 75:2, pages 201-220.
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S. Harmsen, I. Meijerman, J. H. Beijnen & J. H. M. Schellens. (2008) Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor. Cancer Chemotherapy and Pharmacology 64:1, pages 35-43.
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Hyun-Mi Kim & Kwang-Hyeon Liu. (2007) Screening for inhibitory effect on nine CYP isoforms by 20 herbal medications. Journal of Life Science 17:3, pages 334-339.
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Miki Nakajima, Masahiro Itoh, Haruko Sakai, Tatsuki Fukami, Miki Katoh, Hiroshi Yamazaki, Fred F. Kadlubar, Susumu Imaoka, Yoshihiko Funae & Tsuyoshi Yokoi. (2006) CYP2A13 expressed in human bladder metabolically activates 4‐aminobiphenyl. International Journal of Cancer 119:11, pages 2520-2526.
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Daisuke Tenmizu, Kiyoshi Noguchi & Hidetaka Kamimura. (2006) Elucidation of the Effects of the CYP1A2 Deficiency Polymorphism in the Metabolism of 4-Cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1 H )-one (YM-64227), a Phosphodiesterase Type 4 Inhibitor, and Its Metabolites in Dogs . Drug Metabolism and Disposition 34:11, pages 1811-1816.
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Kaoru Kobayashi, Kikuko Urashima, Noriaki Shimada & Kan Chiba. (2003) SELECTIVITIES OF HUMAN CYTOCHROME P450 INHIBITORS TOWARD RAT P450 ISOFORMS: STUDY WITH cDNA-EXPRESSED SYSTEMS OF THE RAT. Drug Metabolism and Disposition 31:7, pages 833-836.
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J. Matthew Hutzler & Timothy S. Tracy. (2002) Atypical Kinetic Profiles in Drug Metabolism Reactions. Drug Metabolism and Disposition 30:4, pages 355-362.
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Miki Nakajima, Kazuhiro Tane, Sumika Nakamura, Noriaki Shimada, Hiroshi Yamazaki & Tsuyoshi Yokoi. (2002) Evaluation of Approach to Predict the Contribution of Multiple Cytochrome P450s in Drug Metabolism Using Relative Activity Factor: Effects of the Differences in Expression Levels of NADPH–Cytochrome P450 Reductase and Cytochrome b5 in the Expression System and the Differences in the Marker Activities. Journal of Pharmaceutical Sciences 91:4, pages 952-963.
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Karthik Venkatakrishnan, Lisa L. von Moltke & David J. Greenblatt. (2013) Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models. The Journal of Clinical Pharmacology 41:11, pages 1149-1179.
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Lucie Boek-Dohalská, Petr Hodek, Miroslav Šulc & Marie Stiborová. (2001) α-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6. Chemico-Biological Interactions 138:1, pages 85-106.
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