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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 7
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Research Article

Metabolism of artelinic acid to dihydroqinghaosu by human liver cytochrome P4503A

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Pages 703-717 | Published online: 22 Sep 2008

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Chandra Bhushan Tripathi, Sarwar Beg, Ripandeep Kaur, Geeta Shukla, Shantanu Bandopadhyay & Bhupinder Singh. (2016) Systematic development of optimized SNEDDS of artemether with improved biopharmaceutical and antimalarial potential. Drug Delivery 23:9, pages 3209-3223.
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David J. Greenblatt, Karthik Venkatakrishnan, Jerold S. Harmatz, Sarah J. Parent & Lisa L. von Moltke. (2010) Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro. Xenobiotica 40:10, pages 713-720.
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Rajeev K Mehlotra, Cara N Henry-Halldin & Peter A Zimmerman. (2009) Application of Pharmacogenomics to Malaria: A Holistic Approach for Successful Chemotherapy. Pharmacogenomics 10:3, pages 435-449.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (23)

Chiratidzo R. Chamboko, Wayde Veldman, Rolland Bantar Tata, Birgit Schoeberl & Özlem Tastan Bishop. (2023) Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles. International Journal of Molecular Sciences 24:4, pages 3383.
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Ioannis Tsamesidis, Farnoush Mousavizadeh, Chinedu Egwu, Dionysia Amanatidou, Antonella Pantaleo, Françoise Benoit-Vical, Karine Reybier & Athanassios Giannis. (2022) In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative. Medicines 9:2, pages 8.
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Ryan Arey & Brad Reisfeld. (2021) Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling. Antimicrobial Agents and Chemotherapy 65:3.
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Thomas Efferth. (2017) Cancer combination therapies with artemisinin-type drugs. Biochemical Pharmacology 139, pages 56-70.
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Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Maneerat Rasameesoraj, Amporn Limsalakpeth, Nitima Chanarat, Natthasorn Komcharoen, Peter J. Weina, David L. Saunders, Montip Gettayacamin & R. Scott Miller. (2016) Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model. Malaria Journal 15:1.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 710 725 .
Leann Tilley, Susan A. Charman & Jonathan L. Vennerstrom. 2011. Neglected Diseases and Drug Discovery. Neglected Diseases and Drug Discovery 33 64 .
Shu-Feng Zhou, Zhi-Wei Zhou & Min Huang. (2010) Polymorphisms of human cytochrome P450 2C9 and the functional relevance. Toxicology 278:2, pages 165-188.
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Eugene G. Hrycay & Stelvio M. Bandiera. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 70 .
Toshiro Niwa, Norie Murayama & Hiroshi Yamazaki. (2010) Comparison of the Contributions of Cytochromes P450 3A4 and 3A5 in Drug Oxidation Rates and Substrate Inhibition. Journal of Health Science 56:3, pages 239-256.
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Qigui Li, Lisa H. Xie, Todd O. Johnson, Yuanzheng Si, Adam S. Haeberle & Peter J. Weina. (2007) Toxicity evaluation of artesunate and artelinate in Plasmodium berghei-infected and uninfected rats. Transactions of the Royal Society of Tropical Medicine and Hygiene 101:2, pages 104-112.
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. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 2183 2195 .
Krishna R. Dronamraju & Paolo AreseRajeev K. Mehlotra & Peter A. Zimmerman. 2006. Malaria: Genetic and Evolutionary Aspects. Malaria: Genetic and Evolutionary Aspects 81 124 .
Lisa H. Xie, Todd O. Johnson, Peter J. Weina, Yuanzheng Si, Adam Haeberle, Ravi Upadhyay, Elaine Wong & Qigui Li. (2016) Risk Assessment and Therapeutic Indices of Artesunate and Artelinate in Plasmodium berghei –Infected and Uninfected Rats . International Journal of Toxicology 24:4, pages 251-264.
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Qigui Li, Lisa H. Xie, Yuanzheng Si, Elaine Wong, Ravi Upadhyay, Danielle Yanez & Peter J. Weina. (2016) Toxicokinetics and Hydrolysis of Artelinate and Artesunate in Malaria-Infected Rats. International Journal of Toxicology 24:4, pages 241-250.
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Bonginkosi Gumede, Peter Folb & Bernhard Ryffel. (2003) Oral artesunate prevents Plasmodium berghei Anka infection in mice. Parasitology International 52:1, pages 53-59.
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Larry C. Wienkers. (2002) Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition. European Journal of Pharmaceutical Sciences 15:3, pages 239-242.
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Mitchell A. Avery, Maria Alvim-Gaston, Carlos R. Rodrigues, Eliezer J. Barreiro, Fred E. Cohen, Yogesh A. Sabnis & John R. Woolfrey. (2001) Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 6. The Development of Predictive In Vitro Potency Models Using CoMFA and HQSAR Methodologies. Journal of Medicinal Chemistry 45:2, pages 292-303.
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Yupin Suputtamongkol, Paul N. Newton, Brian Angus, Paktiya Teja‐Isavadharm, Duangsuda Keeratithakul, Maneerat Rasameesoraj, Sasithon Pukrittayakamee & Nicholas J. White. (2002) A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria. British Journal of Clinical Pharmacology 52:6, pages 655-661.
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R. Walter. 2001. 283 313 .
Visweswaran Navaratnam, Sharif Mahsufi Mansor, Nam-Weng Sit, James Grace, Qigui Li & Piero Olliaro. (2000) Pharmacokinetics of Artemisinin-Type Compounds. Clinical Pharmacokinetics 39:4, pages 255-270.
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Paul Newton, Yupin Suputtamongkol, Paktiya Teja-IsavadharmSasithon Pukrittayakamee, V Navaratnam, Imelda Bates & Nicholas White. (2000) Antimalarial Bioavailability and Disposition of Artesunate in Acute Falciparum Malaria. Antimicrobial Agents and Chemotherapy 44:4, pages 972-977.
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