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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 3
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Research Article

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

Pages 269-279 | Published online: 22 Sep 2008

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Xuechun Yuan, Hui Lu, Anpeng Zhao, Yidan Ding, Qiong Min & Rong Wang. (2020) Transcriptional regulation of CYP3A4 by nuclear receptors in human hepatocytes under hypoxia. Drug Metabolism Reviews 52:2, pages 225-234.
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M. José Gómez-Lechón, Laia Tolosa & M. Teresa Donato. (2017) Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 137-148.
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Petra Matoulková, Petr Pávek, Josef Malý & Jiří Vlček. (2014) Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 425-435.
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Zdenek Dvorak & Peotr Pavek. (2010) Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metabolism Reviews 42:4, pages 621-635.
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M. Miura, K. Inoue, H. Kagaya, M. Saito, T. Habuchi & S. Satoh. (2009) Inter-individual difference determinant of prednisolone pharmacokinetics for Japanese renal transplant recipients in the maintenance stage. Xenobiotica 39:12, pages 939-945.
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Yi-Tong Liu, Hai-Ping Hao, Chang-Xiao Liu, Guang-Ji Wang & Hong-Guang Xie. (2007) Drugs as CYP3A Probes, Inducers, and Inhibitors. Drug Metabolism Reviews 39:4, pages 699-721.
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Jos V Castell, Ramiro Jover, Celia P Martnez-Jimnez & Mara Jos Gmez-Lechn. (2006) Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opinion on Drug Metabolism & Toxicology 2:2, pages 183-212.
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Lesley A. Stanley, Brian C. Horsburgh, Jillian Ross, Nico Scheer & C. Roland Wolf. (2006) PXR and CAR: Nuclear Receptors which Play a Pivotal Role in Drug Disposition and Chemical Toxicity. Drug Metabolism Reviews 38:3, pages 515-597.
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G. Gordon Gibson, Anna Phillips, Sihem Aouabdi, Kate Plant & Nick Plant. (2006) Transcriptional Regulation of the Human Pregnane-X Receptor. Drug Metabolism Reviews 38:1-2, pages 31-49.
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G. G. Gibson, N. J. Plant, K. E. Swales, A. Ayrton & W. El-Sankary. (2002) Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 32:3, pages 165-206.
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Madhav Sachar, Edward J. Kelly & Jashvant D. Unadkat. (2019) Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. The AAPS Journal 21:3.
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K Sanghavi, R C Brundage, M B Miller, D P Schladt, A K Israni, W Guan, W S Oetting, R B Mannon, R P Remmel, A J Matas & P A Jacobson. (2015) Genotype-guided tacrolimus dosing in African-American kidney transplant recipients. The Pharmacogenomics Journal 17:1, pages 61-68.
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Tiong Chai Seah, Yea Lu Tay, Heng Kean Tan, Tengku Sifzizul Tengku Muhammad, Habibah Abdul Wahab & Mei Lan Tan. (2015) Determination of CYP3A4 Inducing Properties of Compounds Using a Laboratory-Developed Cell-Based Assay. International Journal of Toxicology 34:5, pages 454-468.
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