Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 3
171
Views
55
CrossRef citations to date
0
Altmetric
Research Article

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

Pages 269-279 | Published online: 22 Sep 2008

References

  • ADEN, D. P., FOGEL, A., PLOTKIN, S., DAMJANOV, I. and KNOWLES, B. B., 1979, Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature, 282, 615–616.
  • AOYAMA, T., YAMANO, S., GUZELIAN, P. S., GELsous, H. V. and GONZALEZ, F. J., 1990, Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B. Proceedings of the National Academy of Sciences, USA, 87, 4790–4793.
  • BARWICK, J., QUATTROCHI, L., MILLS, A. S., POTENZA, C., TUKEY, R. H. and GUZELIAN, P. S., 1996, Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Molecular Pharmacology, 50, 10–16.
  • BEATO, M., 1989, Gene regulation by steroid hormones. Cell, 56, 335–344.
  • BURGER, H.-J., SCHUETZ, J. D., SCHUETZ, E. G. and GUZELIAN, P. S., 1992, Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16a-carbonitrile : analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proceedings of the National Academy of Sciences, USA, 89, 2145–2149.
  • CASHMAN, J. R., 1996, Drug discovery and drug metabolism. Drug Discovery Today, 1, 209–216.
  • CHOLERTON, S., DALY, A. K. and IDLE, J. R., 1992, The role of individual human cytochromes P450 in drug metabolism and clinical response. TIPS, 13, 434–439.
  • CURI-PEDROSA, R., DAUJAT, M., PICHARD, L., OURLIN, J. C., CLAIR, P., GERVOT, L., LESCA, P., DOMERGUE, J., JoYEux, H., FOURTAN1ER, G. and MAUREL, P., 1994, Omeprazole and lansoprazole are mixed inducers of CYP 1A and CYP 3A in human hepatocytes in primary culture. Journal of Pharmacology and Experimental Therapeutics, 269, 384–392.
  • EVANS, R. M., 1988, The steroid and thyroid hormone receptor superfamily. Science, 240, 889-895. FENSKE, M., 1991, Protein binding of cortisol by means of competitive adsorption: application to cortisol binding by serum of sixteen eutherian mammals. Comparative Biochemistry and Physiology, 98, 61–66.
  • FERRO, M., BASSI, A. M., PENCO, S. and NANNI, G., 1993, Use of established hepatoma cell lines in biotoxicology. Cytotechnology, 11, S126–129.
  • FUKUDA, Y., ISHIDA N., NOGUCHI, T., KAPPAS, A. and SASSA, S., 1992, Interleukin 6 down regulates the expression of transcripts encoding cytochrome P450 1A1, 1A2 and IIIA3 in human hepatoma cells. Biochemical and Biophysical Research Communications, 184, 960–965.
  • GERVOT, L., CARR1ERE, V., COSTET, P., CUGENC, P.-H., BERGER, A., BEAUNE, P. and WAZ1ERS, I. D., 1996, CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines. Environmental Toxicology and Pharmacology, 2, 381–388.
  • GUENGERICH, F. P., 1990, Mechanism-based inactivation of human liver microsomal cytochrome P-450 II1A4 by gestodene. Chemical Research in Toxicology, 3, 363–371.
  • HASHIMOTO, H., TOIDE, K., KITAMURA, R., FUJITA, M., TAGAWA, S., ITOH, S. and KAMATAKI, T., 1993, Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers and its transcriptional control. European Journal of Biochemistry, 218, 585–595.
  • HOSTETLER, K. A., WRIGHTON, S. A., MOLOWA, D. T., THOMAS, P. E., LEVIN, W. and GUZELIAN, P. S., 1988, Co-induction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents. Molecular Pharmacology, 35, 279–285.
  • Huss, J. M., WANG, S. I., ASTROM, A., MCQUIDDY, P. and KASPER, C. B., 1996, Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proceedings of the National Academy of Sciences, USA, 93, 4666–4670.
  • JORDAN, M., SCHALLHORN, A. and WURM, F. M., 1996, Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Research, 24, 596–601.
  • JOUNAIDI, Y., GUZELIAN, P. S., MAUREL, P. and VILAREM, M.-J., 1994, Sequence of the 51flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7. Biochemical and Biophysical Research Communications, 205, 1741–1747.
  • KETTER, T. A., FLOCKHART, D. A., POST, R. M., DENICOFF, K., PAZZAGLIA, P. J., MARANGELL, L. B., GEORGE, M. S. and CALLAHAN, A. M., 1995, The emerging role of cytochrome P450 3A in psychopharmacology. Journal of Clinical Psychopharmacology, 15, 387–398.
  • KITADA, M., KAMATAKI, T., ITAHASHI, K., RIKIHISA, T., KATO, R. and KANAKUBO, Y., 1985, Purification and properties of cytochrome P-450 from homogenates of human fetal livers. Archives of Biochemistry and Biophysics, 241, 275–280.
  • KL1EWER, S. A., MOORE, J. T., WADE, L., STAUDINGER, J. L., WATSON, M. A., Jos, S. A., McKEE, D. D., OLIVER, B. B., WILLSON, T. M., ZETTERSTROM, R. H., PEREVIANN, T. and LEHMANN, J. M., 1998, An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell, 92, 73–82.
  • KOLARS, J. C., LOWN, K. S., SCHM1EDLIN -REN, P., GHOSH, M., FANG, C., WRIGHTON, S. A., MERION, R. M. and WATKINS, P. B., 1994, CYP3A gene expression in human gut epithelium. Pharmacoge-netks, 4, 247–259.
  • KOLARS, J. C., SCHM1EDLIN -REN, P., SCHUETZ, J. D., FANG, C. and WATKINS, P. B., 1992, Identification of rifampicin-inducible P450 II1A4 (CYP3A4) in human small bowel enterocytes. Journal of Clinical Investigation, 90, 1871–1878.
  • KOMORI, M., HASHIZUME, T., OHI, H., MIURA, T., KITADA, M., NAGASHIMA, K. and KAMATAKI, T., 1988, Cytochrome P-450 in human liver microsomes : high-performance liquid chromatographic isolation of three forms and their characterisation. Journal of Biochemistry, 104, 912–916.
  • KRIVORUK, Y., KINIRONS, M. T., WOOD, A. J. J. and WOOD, M., 1994, Metabolism of cytochrome P450 3A substrates in vivo administered by the same route. Lack of correlation between alfentanil clearance and erythromycin breath test. Clinical Pharmacology and Therapeutics, 56, 608–614.
  • LARSEN, M. C., BRAKE, P. B., PARMAR, D. and JEFCOATE, C. R., 1994, The induction of five rat hepatic P450 Cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. Archives of Biochemistry and Biophysics, 315, 24–34.
  • NELSON D. R., KAMATAKI, T., WAXMAN, D. J., GUENGERICH, F. P., ESTABROOK, R. W., FEYEREISEN, R., GONZALEZ, F. J., COON, M. J., GUNSALUS I. C., GOTOH, 0., OKUDA, K. and NEBERT, D. W., 1993, The P450 superfamily : update on new sequences, gene mapping, accession numbers, early trivial names of enzymes and nomenclature. DNA and Cell Biology, 12, 1–51.
  • NELSON D. R., KOYMANS, L., KAMATAKI, T., STEGEMAN J. J., FEYEREISEN, R., WAXMAN, D. J., WATERMAN, M. R., GOTOH, 0., COON, M. J., ESTABROOK, R. W., GUNSALUS I. C. and NEBERT D. W., 1996, P450 superfamily : update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1–42.
  • OGG, M. S., GRAY, T. J. B. and GIBSON, G. G., 1997, Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene. European Journal of Drug Metabolism and Pharmacokinetics, 22, 311–313.
  • PICKWELL, G. V., QUATTROCHI, L., SHIH, H. and GUZELIAN, P. S., 1996, Transcriptional activation of human fetal cytochrome P450 CYP3A7. FASEB Journal, 1346.
  • QUATTROCHI, L., MILLS, A. S., BARWICK, J. L., YOCKEY, C. B. and GUZELIAN, P. S., 1995, A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. Journal of Biological Chemistry, 270, 28917–28923.
  • SCHUETZ, E. G., SCHUETZ, J. D., STROM, S. C., THOMPSON, M. T., FISHER, R. A., MOLOWA, D. T., Li, D. and GUZELIAN, P. S., 1993, Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology, 18, 1254–1262.
  • SCHUETZ, J. D., BEACH, D. L. and GUZELIAN, P. S., 1994, Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver. Pharmacogenetics, 4, 11–20.
  • SCHUETZ, J. D., KAUMA, S. and GUZELIAN, P. S., 1993, Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta. Journal of Clinical Investigation, 92, 1018–1024.
  • SCHUETZ, J. D., SCHUETZ, E. G., THOTTASSERY, J. V., GUZELIAN, P. S., STROM, S. C. and SUN, D., 1996, Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Molecular Pharmacology, 49, 63–72.
  • SHIMADA, T., YAMAZAKI, H., MIMUA, M., INUI, Y. and GUENGERICH, F. P., 1994, Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Journal of Pharmacology and Experimental Therapeutics, 270, 414–423.
  • TOMLINSON, R., YOUNG, R. P., NG, M. C. Y., ANDERSON, P. J., KAY, R. and CRITCHLEY, J. A. J. H., 1996, Selective liver enzyme induction by carbamazepine and phenytoin in Chinese epileptics. Journal of Clinical Pharmacology, 50, 411–415.
  • WATKINS, P. B., MURRAY, S. A., WINICELMAN, L. G., HEUMAN, D. M., WRIGHTON, S. A. and GUZELIAN P. S., 1989, Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Journal of Clinical Investigation, 83, 688–697.
  • WATKINS, P. B., WRIGHTON, S. A., SCHUETZ, E.G., MAUREL, P. and GUZELIAN, P. S., 1986, Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture. Journal of Biological Chemistry, 261, 6264–6271.
  • WEBER, M., MOLLER, K., WELZEK, M. and SCHORR, J., 1996, Effect of endotoxins on transfection efficiency in eukaryotic cells. Qiagen News, 4–5.
  • WILLIAMS, J. A., CHENERY, R. J. and HAWKSWORTH, G. M., 1994, Induction of CYP3A enzymes in human and rat hepatocyte cultures. Biochemical Society Transactions, 22, 131s.
  • WILLIAMS, J. M. 1997, Drug regulation of the human cytochrome P450 gene, CYP 3A4. PhD thesis, University of Surrey.
  • WRIGHT, M. C. and PAINE, A. J., 1994, Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding if inducers to a microsomal protein. Biochemical and Biophysical Research Communications, 201, 973–979.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.