Citations (59)
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Paula Viviani, Adrián L. Lifschitz, Jorge P. García, María Laura Maté, Miguel A. Quiroga, Carlos E. Lanusse & Guillermo L. Virkel. (2017) Assessment of liver slices for research on metabolic drug–drug interactions in cattle. Xenobiotica 47:11, pages 933-942.
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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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Costas Ioannides. (2013) Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices. Xenobiotica 43:1, pages 15-28.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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K. Ohyama, S. Maki, K. Sato & Y. Kato. (2005) Comparative in vitro metabolism of methoxychlor in male and female rats: Metabolism of demethylated methoxychlor metabolites by precision-cut rat liver slices. Xenobiotica 35:7, pages 683-695.
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K. Ohyama, S. Maki, K. Sato & Y. Kato. (2005) Comparative in vitro metabolism of the suspected pro-oestrogenic compound, methoxychlor in precision-cut liver slices from male and female rats. Xenobiotica 35:4, pages 331-342.
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K. Ohyama, S. Maki, K. Sato & Y. Kato. (2004) In vitro metabolism of [14C]methoxychlor in rat, mouse, Japanese quail and rainbow trout in precision-cut liver slices. Xenobiotica 34:8, pages 741-754.
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M. Umachandran, J. Howarth & C. Ioannides. (2004) Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica 34:8, pages 771-780.
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Articles from other publishers (51)
Iqra Azam & James D. Benson. (2024) Multiscale transport and 4D time-lapse imaging in precision-cut liver slices (PCLS). PeerJ 12, pages e16994.
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Julia Herbert, Debra L. Laskin, Andrew J. Gow & Jeffrey D. Laskin. (2020) Chemical warfare agent research in precision‐cut tissue slices—a useful alternative approach. Annals of the New York Academy of Sciences 1480:1, pages 44-53.
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Daphnee S. Pushparajah & Costas Ioannides. (2018) Antagonistic and synergistic interactions during the binding of binary mixtures of polycyclic aromatic hydrocarbons to the aryl hydrocarbon receptor. Toxicology in Vitro 50, pages 54-61.
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Gerald Burgstaller, Arunima Sengupta, Sarah Vierkotten, Gerhard Preissler, Michael Lindner, Jürgen Behr, Melanie Königshoff & Oliver Eickelberg. (2018) Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures. American Journal of Physiology-Lung Cellular and Molecular Physiology 314:5, pages L708-L723.
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Daphnee Pushparajah, DFV Lewis & Costas Ioannides. (2017) Up-regulation of CYP1A1 and phase II enzymes by 5-ring isomeric polycyclic aromatic hydrocarbons in precision-cut rat hepatic slices: Importance of molecular shape. Toxicology in Vitro 40, pages 203-213.
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Daphnee S. Pushparajah, Kathryn E. Plant, Nick J. Plant & Costas Ioannides. (2017) Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices. Environmental Toxicology 32:3, pages 764-775.
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Gerald Burgstaller, Sarah Vierkotten, Michael Lindner, Melanie Königshoff & Oliver Eickelberg. (2015) Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue. American Journal of Physiology-Lung Cellular and Molecular Physiology 309:4, pages L323-L332.
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Ahmad Faizal Abdull Razis, Nattaya Konsue & Costas Ioannides. (2015) Inhibitory effect of Phenethyl Isothiocyanate Against Benzo[a] Pyrene-Induced Rise in CYP1A1 mRNA and Apoprotein Levels as its Chemopreventive Properties. Asian Pacific Journal of Cancer Prevention 16:7, pages 2679-2683.
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Mostafa Kabiri. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
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Alexander V. LyubimovCostas Ioannides & Brian G. Lake. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
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Ahmad F. Abdull Razis, Natalya Hanlon, Ewa Soltys, Veronika Krizova, Renato Iori, Kathryn E. Plant, Nick Plant & Costas Ioannides. (2012) The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Archives of Toxicology 86:10, pages 1505-1514.
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Ahmad F. Abdull Razis, Manuela Bagatta, Gina R. De Nicola, Renato Iori, Nick Plant & Costas Ioannides. (2012) Characterization of the Temporal Induction of Hepatic Xenobiotic-Metabolizing Enzymes by Glucosinolates and Isothiocyanates: Requirement for at Least a 6 h Exposure To Elicit Complete Induction Profile. Journal of Agricultural and Food Chemistry 60:22, pages 5556-5564.
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Ahmad F. Abdull Razis, Nattaya Konsue, Myrto Dervetzoglou, Kathryn E. Plant, Nick Plant & Costas Ioannides. (2011) Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor. Molecular Nutrition & Food Research 56:3, pages 425-434.
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Ahmed Faizal Abdull Razis, Gina Rosalinda De Nicola, Eleonora Pagnotta, Renato Iori & Costas Ioannides. (2011) 4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent. Archives of Toxicology 86:2, pages 183-194.
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Francis Finot, Régis Masson, Fabienne Desmots, Catherine Ribault, Nicole Bichet, Joan A. Vericat, Patricia Lafouge, Christiane Guguen-Guillouzo & Pascal Loyer. (2012)
Combined Stimulation with the Tumor Necrosis Factor
and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices
. International Journal of Hepatology 2012, pages 1-14.
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Ahmad Faizal Abdull Razis, Manuela Bagatta, Gina Rosalinda De Nicola, Renato Iori & Costas Ioannides. (2010) Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. Archives of Toxicology 85:8, pages 919-927.
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Ahmad Faizal Abdull Razis, Renato Iori & Costas Ioannides. (2010)
The natural chemopreventive phytochemical
R
‐sulforaphane is a far more potent inducer of the carcinogen‐detoxifying enzyme systems in rat liver and lung than the
S
‐isomer
. International Journal of Cancer 128:12, pages 2775-2782.
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Ahmad F. Abdull Razis, Manuela Bagatta, Gina R. De Nicola, Renato Iori & Costas Ioannides. (2010) Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables. Toxicology 277:1-3, pages 74-85.
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Nattaya Konsue & Costas Ioannides. (2010) Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450. Archives of Toxicology 84:10, pages 751-759.
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Nattaya Konsue & Costas Ioannides. (2010) Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate. Molecular Nutrition & Food Research 54:10, pages 1477-1485.
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Nattaya Konsue & Costas Ioannides. (2010) Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables. Toxicology 268:3, pages 184-190.
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Natalya Hanlon, Charlotte L. Poynton, Nick Coldham, Maurice J. Sauer & Costas Ioannides. (2009) The aliphatic isothiocyanates erucin and sulforaphane do not effectively up‐regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat. Molecular Nutrition & Food Research 53:7, pages 836-844.
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Natalya Hanlon, Nick Coldham, Maurice J. Sauer & Costas Ioannides. (2008) Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane. Toxicology 252:1-3, pages 92-98.
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Y. C. M. Staal, D. S. Pushparajah, M. H. M. van Herwijnen, R. W. H. Gottschalk, L. M. Maas, C. Ioannides, F. J. van Schooten & J. H. M. van Delft. (2008) Interactions between polycyclic aromatic hydrocarbons in binary mixtures: Effects on gene expression and DNA adduct formation in precision-cut rat liver slices. Mutagenesis 23:6, pages 491-499.
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D. S. Pushparajah, M. Umachandran, K. E. Plant, N. Plant & C. Ioannides. (2008) Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung. Mutagenesis 23:4, pages 299-308.
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Daphnee S. Pushparajah, Meera Umachandran, Kathryn E. Plant, Nick Plant & Costas Ioannides. (2008) Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: Studies using precision-cut tissue slices. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 640:1-2, pages 153-161.
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Laure Poquet, Michael N. Clifford & Gary Williamson. (2008) Investigation of the metabolic fate of dihydrocaffeic acid. Biochemical Pharmacology 75:5, pages 1218-1229.
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Daphnee S. Pushparajah, Meera Umachandran, Tariq Nazir, Kathryn E. Plant, Nick Plant, David F.V. Lewis & Costas Ioannides. (2008) Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Toxicology in Vitro 22:1, pages 128-145.
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Meera Umachandran & Costas Ioannides. (2007) Interactions between polycyclic aromatic hydrocarbons in precision-cut rat lung slices. Toxicology 240:3, pages 164-165.
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Daphnee S. Pushparajah, Meera Umachandran, Kathryn E. Plant, Nick Plant & Costas Ioannides. (2007) Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities. Toxicology 231:1, pages 68-80.
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Yvonne C.M. Staal, Marcel H.M. van Herwijnen, Daphnee S. Pushparajah, Meera Umachandran, Costas Ioannides, Frederik J. van Schooten & Joost H.M. van Delft. (2007) Modulation of gene expression and DNA-adduct formation in precision-cut liver slices exposed to polycyclic aromatic hydrocarbons of different carcinogenic potency. Mutagenesis 22:1, pages 55-62.
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Karl SchumacherYuet-Mei KhongShi ChangJun NiWanxin SunHanry Yu. (2007) Perfusion Culture Improves the Maintenance of Cultured Liver Tissue Slices. Tissue Engineering 13:1, pages 197-205.
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Karl Schumacher, Yuet-Mei Khong, Shi Chang, Jun Ni, Wanxin Sun & Hanry Yu. (2006) Perfusion Culture Improves the Maintenance of Cultured Liver Tissue Slices. Tissue Engineering 0:0, pages 061220075423003.
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Debra J. Skene, Sarah E. Timbers, Benita Middleton, Judie English, Caroline Kopp, Irene Tobler & Costas Ioannides. (2006) Mice convert melatonin to 6-sulphatoxymelatonin. General and Comparative Endocrinology 147:3, pages 371-376.
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Meera Umachandran & Costas Ioannides. (2006) Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72h. Toxicology 224:1-2, pages 14-21.
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Yvonne CM Staal, Marcel HM van Herwijnen, Frederik J van Schooten & Joost HM van Delft. (2005) Application of four dyes in gene expression analyses by microarrays. BMC Genomics 6:1.
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S. Sivapathasundaram, L. C. Howells, M. J. Sauer & C. Ioannides. (2004) Functional integrity of precision‐cut liver slices from deer and cattle. Journal of Veterinary Pharmacology and Therapeutics 27:2, pages 79-84.
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Hideki Nonaka, Hirohiko Ise, Nobuhiro Sugihara, Shinichi Hirose, Naoki Negishi, Yoshiyuki Kondo & Toshihiro Akaike. (2017) Development of Highly Functional Long-Term Culture Method of Liver Slice Embedded in Agarose Gel for Bioartificial Liver. Cell Transplantation 12:5, pages 491-498.
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I.A.M de Graaf & H.J Koster. (2003) Cryopreservation of precision-cut tissue slices for application in drug metabolism research. Toxicology in Vitro 17:1, pages 1-17.
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Dagmar Neupert, Reinhild Glöckner, Gunther Neupert & Dieter Müller. (2003) Ultrastructural changes in hepatocytes of precision-cut rat liver slices after incubation for 24 and 48 hours. Experimental and Toxicologic Pathology 54:5-6, pages 481-488.
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Bert Haenen, Cathy Rompelberg, Klaas van Twillert, Martin Hamzink, Jan Dormans & Jan van Eijkeren. (2002) Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency. Drug Metabolism and Disposition 30:3, pages 307-313.
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Michael B. Fisher, David Jackson, Andreas Kaerner, Steven A. Wrighton & Anthony G. Borel. (2002) Characterization by Liquid Chromatography-Nuclear Magnetic Resonance Spectroscopy and Liquid Chromatography-Mass Spectrometry of Two Coupled Oxidative-Conjugative Metabolic Pathways for 7-Ethoxycoumarin in Human Liver Microsomes Treated with Alamethicin. Drug Metabolism and Disposition 30:3, pages 270-275.
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E Evdokimova, H Taper & P Buc Calderon. (2002) Effects of bacterial endotoxin (lipopolysaccharides) on survival and metabolism of cultured precision-cut rat liver slices. Toxicology in Vitro 16:1, pages 47-54.
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E. Evdokimova, H. Taper & P. Buc Calderon. (2001) Role of ATP and glycogen reserves in both paracetamol sulfation and glucuronidation by cultured precision-cut rat liver slices. Toxicology in Vitro 15:6, pages 683-690.
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Keiichiro Yoneyama. (2006) Three‐dimensional visualization and physiologic evaluation of bile canaliculi in the rat liver slice by confocal laser scanning microscopy. Scanning 23:6, pages 359-365.
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Elmar Richter, Susanne Friesenegger, Johannes Engl & Anthony R. Tricker. (2000) Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by hamster lung, liver and kidney. Toxicology 144:1-3, pages 83-91.
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Elisabeth George, Janice Murdock, Mike Aylott & Carl Westmoreland. (2019)
Comparison of Hepatocyte Cultures and Liver Slices in
In Vitro
Toxicity Testing
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