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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 1
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Research Article

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

Pages 53-75 | Published online: 22 Sep 2008

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Guru R. Valicherla, Amrut Mishra, Srinivas Lenkalapelly, Bhupathi Jillela, Femi M. Francis, Lakshman Rajagopalan & Pratima Srivastava. (2019) Investigation of the inhibition of eight major human cytochrome P450 isozymes by a probe substrate cocktail in vitro with emphasis on CYP2E1. Xenobiotica 49:12, pages 1396-1402.
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Yannick Parmentier, Corinne Pothier, Nicola Hewitt, Ludwig Vincent, Fabrice Caradec, Jia Liu, Feifei Lin, Marie-Michèle Trancart, Fabrice Guillet, Belkacem Bouaita, Christophe Chesne & Bernard Walther. (2019) Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model. Xenobiotica 49:1, pages 22-35.
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Robert M Levy, Lakshmi Pillai & Bruce P Burnett. (2010) Nutritional benefits of flavocoxid in patients with osteoarthritis: efficacy and safety. Nutrition and Dietary Supplements 2, pages 27-38.
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James J Cali, Andrew Niles, Michael P Valley, Martha A O'Brien, Terry L Riss & John Shultz. (2008) Bioluminescent assays for ADMET. Expert Opinion on Drug Metabolism & Toxicology 4:1, pages 103-120.
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Thomas M Polasek & John O Miners. (2007) In vitro approaches to investigate mechanism-based inactivation of CYP enzymes. Expert Opinion on Drug Metabolism & Toxicology 3:3, pages 321-329.
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Jan L Wahlstrom, Dan A Rock, J Greg Slatter & Larry C Wienkers. (2006) Advances in predicting CYP-mediated drug interactions in the drug discovery setting. Expert Opinion on Drug Discovery 1:7, pages 677-691.
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James J Cali, Dongping Ma, Mary Sobol, Daniel J Simpson, Susan Frackman, Troy D Good, William J Daily & David Liu. (2006) Luminogenic cytochrome P450 assays. Expert Opinion on Drug Metabolism & Toxicology 2:4, pages 629-645.
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M. G. Soars, K. Grime & R. J. Riley. (2006) Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5. Xenobiotica 36:4, pages 287-299.
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K. H. Liu, M. J. Kim, J. H. Shon, Y. S. Moon, S. Y. Seol, W Kang, I. J. Cha & J. G. Shin. (2005) Stereoselective inhibition of cytochrome P450 forms by lansoprazole and omeprazole in vitro. Xenobiotica 35:1, pages 27-38.
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M. Jane Cox Rosemond & John S. Walsh. (2004) Human Carbonyl Reduction Pathways and a Strategy for Their Study In Vitro. Drug Metabolism Reviews 36:2, pages 335-361.
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M. N. V. S. Rao, B. Biju, A. K. Ansar, S. Mujeeb, M. Ramesh & N. R. Srinivas. (2003) ‘Open access’ generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies. Xenobiotica 33:12, pages 1233-1245.
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N. Hagen, A. K. Olsen, J. V. Andersen, J. Tjørnelund & S. H. Hansen. (2002) Characterization of mixtures of recombinant human cytochrome P450s as a screening model for metabolic stability in drug discovery. Xenobiotica 32:9, pages 749-759.
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H. Yin, J. Racha, S.-Y. Li, N. Olejnik, H. Satoh & D. Moore. (2000) Automated high throughput human CYP isoform activity assay using SPE-LC/MS method: application in CYP inhibition evaluation. Xenobiotica 30:2, pages 141-154.
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