479
Views
139
CrossRef citations to date
0
Altmetric
Original Articles

THE ROLE OF METABOLISM AND SPECIFIC METABOLITES IN BENZENE-INDUCED TOXICITY: EVIDENCE AND ISSUES

Pages 357-372 | Published online: 30 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (20)

Gebre Teklu, Mikias Negash, Tsegay Asefaw, Feven Tesfay, Gebreslassie Gebremariam, Gebreyohannes Teklehaimanot, Mistire Wolde & Aster Tsegaye. (2021) Effect of Gasoline Exposure on Hematological Parameters of Gas Station Workers in Mekelle City, Tigray Region, Northern Ethiopia. Journal of Blood Medicine 12, pages 839-847.
Read now
José Luis Martínez-Rodríguez, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes-Estrada, Angelica Judith Granados-López, Tatiana Arcos-Ortega & Jesús Adrián López. (2018) Quantitative measurement of oxidative damage in erythrocytes as indicator in benzene intoxications. Toxicology Mechanisms and Methods 28:6, pages 450-460.
Read now
Sherilyn A. Gross & Dennis J. Paustenbach. (2018) Shanghai Health Study (2001–2009): What was learned about benzene health effects?. Critical Reviews in Toxicology 48:3, pages 217-251.
Read now
I. Khaled, H. Ferjani, A. V. Sirotkin, S. Alwasel & A. H. Harrath. (2017) Impact of oil-related environmental pollutants on the ovary structure in the freshwater leech Erpobdella johanssoni (Johansson, 1927) (Clitellata: Hirudinea). The European Zoological Journal 84:1, pages 286-293.
Read now
Ling-li Ye, Guang-hui Zhang, Jing-wen Huang, Yong Li, Guo-qiao Zheng, De-ting Zhang, Li-fang Zhou, Xi-dan Tao, Jing Zhang, Yun-jie Ye, Pin Sun, Arthur Frank & Zhao-lin Xia. (2015) Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?. International Journal of Occupational and Environmental Health 21:3, pages 232-240.
Read now
Yeshvandra Verma & S.V.S. Rana. (2014) Influence of testosterone on phase-II enzymes in liver and kidney of benzene-treated rats. Toxicological & Environmental Chemistry 96:8, pages 1238-1247.
Read now
David Galbraith, Sherilyn A. Gross & Dennis Paustenbach. (2010) Benzene and human health: A historical review and appraisal of associations with various diseases. Critical Reviews in Toxicology 40:sup2, pages 1-46.
Read now
Juan Zhang, Lihong Yin, Geyu Liang, Ran Liu & Yuepu Pu. (2010) Detection of Quinone Oxidoreductase 1 (NQO1) Single-Nucleotide Polymorphisms (SNP) Related to Benzenemetabolism in Immortalized B Lymphocytes From A Chinese Han Population. Journal of Toxicology and Environmental Health, Part A 73:7, pages 490-498.
Read now
F. Yang & J.-H. Zhou. (2010) Cytotoxicity and DNA Damage Induced By 1, 4-Benzoquinone in V79 Chinese Hamster Lung Cells. Journal of Toxicology and Environmental Health, Part A 73:7, pages 483-489.
Read now
Yang Jee Kim, Hae Dong Woo, Byeong Mo Kim, Young Joon Lee, Su Jin Kang, Yoon Hee Cho & Hai Won Chung. (2009) Risk Assessment of Hydroquinone: Differential Responses of Cell Growth and Lethality Correlated to Hydroquinone Concentration. Journal of Toxicology and Environmental Health, Part A 72:21-22, pages 1272-1278.
Read now
Seymour Garte, Emanuela Taioli, Todor Popov, Claudia Bolognesi, Peter Farmer & Franco Merlo. (2008) Genetic Susceptibility to Benzene Toxicity in Humans. Journal of Toxicology and Environmental Health, Part A 71:22, pages 1482-1489.
Read now
MandyL. Olsgard, GaryR. Bortolotti, BrendaR. Trask & JuditE. G. Smits. (2008) Effects of Inhalation Exposure to a Binary Mixture of Benzene and Toluene on Vitamin A Status and Humoral and Cell-Mediated Immunity in Wild and Captive American Kestrels. Journal of Toxicology and Environmental Health, Part A 71:16, pages 1100-1108.
Read now
Yang Jee Kim, Jun Yeol Choi, Domyung Paek & Hai Won Chung. (2008) Association of the NQO1, MPO, and XRCC1 Polymorphisms and Chromosome Damage Among Workers at a Petroleum Refinery. Journal of Toxicology and Environmental Health, Part A 71:5, pages 333-341.
Read now
Shou-Yong Gu, Zhong-Bin Zhang, Jun-Xiang Wan, Xi-Peng Jin & Zhao-Lin Xia. (2007) Genetic Polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 Genes and Correlation with Benzene Exposure in a Chinese Occupational Population. Journal of Toxicology and Environmental Health, Part A 70:11, pages 916-924.
Read now
Juan Zhang, Fang-Yan Zhu, Yue-Pu Pu, Li-Hong Yin, Juan Luo, Wei-Peng Wang & Guo-Hua Zhou. (2007) Analysis of Multiple Single Nucleotide Polymorphisms (SNPs) of Myeloperoxidase (MPO) to Screen for Genetic Markers Associated with Acute Leukemia in Chinese Han Population. Journal of Toxicology and Environmental Health, Part A 70:11, pages 901-907.
Read now
Patrick L. Sheets & Gary P. Carlson. (2004) Kinetic Factors Involved in the Metabolism of Benzene in Mouse Lung and Liver. Journal of Toxicology and Environmental Health, Part A 67:5, pages 421-430.
Read now
Glenn Ritchie, Kenneth Still, John Rossi III, Marni Bekkedal, Andrew Bobb & Darryl Arfsten. (2003) Biological And Health Effects Of Exposure To Kerosene-Based Jet Fuels And Performance Additives. Journal of Toxicology and Environmental Health, Part B 6:4, pages 357-451.
Read now
Alessandra Verdina, Rossella Galati, Giuliana Falasca, Sergio Ghittori, Marcello Imbriani, Francesco Tomei, Laura Marcellini, Andrea Zijno, Valentina Del Vecchio & Riccardo Crebelli. (2001) METABOLIC POLYMORPHISMS AND URINARY BIOMARKERS IN SUBJECTS WITH LOW BENZENE EXPOSURE. Journal of Toxicology and Environmental Health, Part A 64:8, pages 607-618.
Read now
Yu-Yang Lu, Hao-En Chen & Wei-Liang Chen. Negative Association of Serum β-Cryptoxanthin With Benzene and Its Derivatives. Journal of the American Nutrition Association 0:0, pages 1-7.
Read now

Articles from other publishers (119)

Razzagh Rahimpoor, Hamed Jalilian, Heidar Mohammadi & Abdulrasoul Rahmani. (2023) Biological exposure indices of occupational exposure to benzene: A systematic review. Heliyon 9:11, pages e21576.
Crossref
Liang-Jun Wang, Yuan-Chin Lee, Jing-Ting Chiou, Ying-Jung Chen & Long-Sen Chang. (2022) Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells. Cell Biology and Toxicology 39:5, pages 2207-2225.
Crossref
Jiaqi Ren, Ying Huang, Jiani Yao, Shujie Zheng, Yingjie Zhao, Yang Hou, Bin Yang, Lecheng Lei, Zhongjian Li & Dionysios D. Dionysiou. (2023) The role of reactive phosphate species in the abatement of micropollutants by activated peroxymonosulfate in the treatment of phosphate-rich wastewater. Water Research 243, pages 120341.
Crossref
Benjamin Atta Owusu, Apiradee Lim, Nitinun Pongsiri, Chanthip Intawong, Sunthorn Rheanpumikankit, Saijit Suksri & Thammasin Ingviya. (2023) Latent Trajectories of Haematological, Hepatic, and Renal Profiles after Oil Spill Exposure: A Longitudinal Analysis. International Journal of Environmental Research and Public Health 20:4, pages 2871.
Crossref
Dianpeng Wang, Dafeng Lin, Gangquan Feng, Xiangli Yang, Lidan Deng, Peimao Li, Zhimin Zhang, Wen Zhang, Yan Guo, Yue Wang, Song Fu & Naixing Zhang. (2023) Impact of chronic benzene poisoning on aberrant mitochondrial DNA methylation: A prospective observational study. Frontiers in Public Health 11.
Crossref
Paola Mozzoni, Diana Poli, Silvana Pinelli, Sara Tagliaferri, Massimo Corradi, Delia Cavallo, Cinzia Lucia Ursini & Daniela Pigini. (2023) Benzene Exposure and MicroRNAs Expression: In Vitro, In Vivo and Human Findings. International Journal of Environmental Research and Public Health 20:3, pages 1920.
Crossref
Mansooreh Dehghani, Alireza Abbasi, Ziba Taherzadeh & Samaneh Dehghani. (2022) Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach. Scientific Reports 12:1.
Crossref
Wei Zhang, Jingyu Wang, ZiYan Liu, Lei Zhang, Jiaru Jing, Lin Han & Ai Gao. (2022) Iron-dependent ferroptosis participated in benzene-induced anemia of inflammation through IRP1-DHODH-ALOX12 axis. Free Radical Biology and Medicine 193, pages 122-133.
Crossref
Diana Poli, Paola Mozzoni, Silvana Pinelli, Delia Cavallo, Bruno Papaleo & Lidia Caporossi. (2022) Sex Difference and Benzene Exposure: Does It Matter?. International Journal of Environmental Research and Public Health 19:4, pages 2339.
Crossref
Ata Rafiee, Juana Maria Delgado-Saborit, Peter D. Sly, Hoda Amiri & Mohammad Hoseini. (2022) Exploring urinary biomarkers to assess oxidative DNA damage resulting from BTEX exposure in street children. Environmental Research 203, pages 111725.
Crossref
Abdulkarem Alrezaki, Nouf Aldawood, Lamjed Mansour, Mukhtar Ahmed, Alexander V. Sirotkin, Saleh Alwasel & Abdel Halim Harrath. (2021) Toluene Can Disrupt Rat Ovarian Follicullogenesis and Steroidogenesis and Induce Both Autophagy and Apoptosis. Biology 10:11, pages 1153.
Crossref
Jen E. Werner & Jennifer A. Swift. (2021) Organic solvates in the Cambridge Structural Database. CrystEngComm 23:7, pages 1555-1565.
Crossref
Jiong Gao, Jie Song, Jinshao Ye, Xiaodi Duan, Dionysios D. Dionysiou, Jagjit S. Yadav, Mallikarjuna N. Nadagouda, Lixia Yang & Shenglian Luo. (2021) Comparative toxicity reduction potential of UV/sodium percarbonate and UV/hydrogen peroxide treatments for bisphenol A in water: An integrated analysis using chemical, computational, biological, and metabolomic approaches. Water Research 190, pages 116755.
Crossref
Vladan Radosavljević. (2021) Urinary metabolites as indicators of human exposure to chemical carcinogens. Zdravstvena zastita 50:4, pages 21-42.
Crossref
Esmaeel Soleimani. (2020) Benzene, toluene, ethylbenzene, and xylene: Current analytical techniques and approaches for biological monitoring. Reviews in Analytical Chemistry 39:1, pages 168-187.
Crossref
Yunqiu Pu, Fengxia Sun, Rongli Sun, Zhaodi Man, Shuangbin Ji, Kai Xu, Lihong Yin, Juan Zhang & Yuepu Pu. (2020) PTP4A3, A Novel Target Gene of HIF-1alpha, Participates in Benzene-Induced Cell Proliferation Inhibition and Apoptosis through PI3K/AKT Pathway. International Journal of Environmental Research and Public Health 17:3, pages 910.
Crossref
Abhishek Raj & Vasanthi Nachiappan. (2019) Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae. Toxicology Research 8:6, pages 1035-1041.
Crossref
Xuejing Yang, Yedan Lu, Fuhong He, Fenxia Hou, Caihong Xing, Peiyu Xu & Qian-Fei Wang. (2019) Benzene metabolite hydroquinone promotes DNA homologous recombination repair via the NF-κB pathway. Carcinogenesis 40:8, pages 1021-1030.
Crossref
Qiang Tan, Jieyou Li, Jianming Peng, Zhidong Liu, Jiaxian Liu, Haiqiao Zhang, Qian Yuan, Zhijie Pan & Linhua Liu. (2018) E4F1 silencing inhibits the cell growth through cell‐cycle arrest in malignant transformed cells induced by hydroquinone. Journal of Biochemical and Molecular Toxicology 33:4.
Crossref
Zhiming Gui, Haiqiao Zhang, Qiang Tan, Xiaoxuan Ling, Zhidong Liu, Jianming Peng, Junli Shao, Minhua Wu, Qian Yuan, Jieyou Li, Zhijie Pan, Baisen Zhong & Linhua Liu. (2019) Poly(ADP-ribose) polymerase-1 promotes expression of miR-155 by the up-regulation of methyl-CpG binding domain protein 2 in TK6 cells exposed to hydroquinone. Toxicology in Vitro 55, pages 51-57.
Crossref
Liping Chen, Ping Guo, Haiyan Zhang, Wenxue Li, Chen Gao, Zhenlie Huang, Junling Fan, Yuling Zhang, Xue Li, Xiaoling Liu, Fangping Wang, Shan Wang, Qingye Li, Zhini He, Huiyao Li, Shen Chen, Xiaonen Wu, Lizhu Ye, Qiong Li, Huanwen Tang, Qing Wang, Guanghui Dong, Yongmei Xiao, Wen Chen & Daochuan Li. (2019) Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1. Journal of Biological Chemistry 294:7, pages 2486-2499.
Crossref
Cristiane Barata Silva, Caroline de Lima Mota, Yasmin Rocha Almeida, Vanessa Emídio, Antonio Sergio A. Fonseca, Simone Mitri & Josino Costa Moreira. (2019) Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G>C and NQO1 609C>T) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil. Cadernos de Saúde Pública 35:7.
Crossref
Jin-Ha Yoon, Woo Seok Kwak & Yeon-Soon Ahn. (2018) A brief review of relationship between occupational benzene exposure and hematopoietic cancer. Annals of Occupational and Environmental Medicine 30:1.
Crossref
Shuqiang Sun, Chunxiao Zhang, Jiahao Gao, Qiongyu Qin, Yaya Zhang, Hua Zhu, Xinjun Yang, Dongren Yang & Hongtao Yan. (2018) Benzoquinone induces ROS-dependent mitochondria-mediated apoptosis in HL-60 cells. Toxicology and Industrial Health 34:4, pages 270-281.
Crossref
Wenting Han, Shuo Wang, Ming Li, Lulu Jiang, Xujing Wang & Keqin Xie. (2018) The protective effect of diallyl trisulfide on cytopenia induced by benzene through modulating benzene metabolism. Food and Chemical Toxicology 112, pages 393-399.
Crossref
Kun Dai, Qingni Yu, Zhou Zhang, Yuan Wang & Xinming Wang. (2018) Aromatic hydrocarbons in a controlled ecological life support system during a 4-person-180-day integrated experiment. Science of The Total Environment 610-611, pages 905-911.
Crossref
Mahendra P. Singh & Ranjana Himalian. 2018. Trends in Insect Molecular Biology and Biotechnology. Trends in Insect Molecular Biology and Biotechnology 53 65 .
Wenting Han, Shuo Wang, Lulu Jiang, Hui Wang, Ming Li, Xujing Wang & Keqin Xie. (2017) Diallyl trisulfide (DATS) suppresses benzene-induced cytopenia by modulating haematopoietic cell apoptosis. Environmental Pollution 231, pages 301-310.
Crossref
Yan Fang, Han-Tian Wu, Yun-Jie Ye, Li-Fang Zhou, Wei Hu, Guang-Hui Zhang, Pin Sun, William Au & Zhao-Lin Xia. (2017) Association Between Polymorphisms of Metabolic Enzyme Genes and Chromosomal Damage in Benzene-Exposed Workers in China. Journal of Occupational & Environmental Medicine 59:11, pages e215-e220.
Crossref
Jihye Lee, Young Joong Kang, Jungho Ahn & Seng-Ho Song. (2017) Indolent B-Cell Lymphoid Malignancy in the Spleen of a Man Who Handled Benzene: Splenic Marginal Zone Lymphoma. Safety and Health at Work 8:3, pages 315-317.
Crossref
Brett T. Doherty, Richard K. Kwok, Matthew D. Curry, Christine Ekenga, David Chambers, Dale P. Sandler & Lawrence S. Engel. (2017) Associations between blood BTEXS concentrations and hematologic parameters among adult residents of the U.S. Gulf States. Environmental Research 156, pages 579-587.
Crossref
Jiaxin Cui, Lieyu Zhang, Beidou Xi, Jing Zhang & Xuhui Mao. (2017) Chemical oxidation of benzene and trichloroethylene by a combination of peroxymonosulfate and permanganate linked by in-situ generated colloidal/amorphous MnO2. Chemical Engineering Journal 313, pages 815-825.
Crossref
Ying-Jung Chen, Wen-Hsin Liu & Long-Sen Chang. (2016) Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells. Archives of Toxicology 91:2, pages 983-997.
Crossref
M?nica Villalba-Campos, Lilian Chuaire-Noack, Magda Carolina S?nchez-Corredor & Milena Rond?n-Lagos. (2016) High chromosomal instability in workers occupationally exposed to solvents and paint removers. Molecular Cytogenetics 9:1.
Crossref
David V. Gauvin, Joshua D. Yoder, David L. Holdsworth, Marci L. Harter, Jonelle R. May, Noelle Cotey, Jill A. Dalton & Theodore J. Baird. (2016) The standardized functional observational battery: Its intrinsic value remains in the instrument of measure: The rat. Journal of Pharmacological and Toxicological Methods 82, pages 90-108.
Crossref
Rongli Sun, Meng Cao, Juan Zhang, Wenwen Yang, Haiyan Wei, Xing Meng, Lihong Yin & Yuepu Pu. (2016) Benzene Exposure Alters Expression of Enzymes Involved in Fatty Acid β-Oxidation in Male C3H/He Mice. International Journal of Environmental Research and Public Health 13:11, pages 1068.
Crossref
Sabrina Angelini, Justo Lorenzo Bermejo, Gloria Ravegnini, Giulia Sammarini & Patrizia Hrelia. (2016) Application of the lymphocyte Cytokinesis-Block Micronucleus Assay to populations exposed to petroleum and its derivatives: Results from a systematic review and meta-analysis. Mutation Research/Reviews in Mutation Research 770, pages 58-72.
Crossref
K. Y. Tang, C. H. Yu, L. Jiang, M. Gong, W. J. Liu, Y. Wang, N. X. Cui, W. Song, Y. Sun & Z. C. Yi. (2016) Long-term exposure of K562 cells to benzene metabolites inhibited erythroid differentiation and elevated methylation in erythroid specific genes. Toxicology Research 5:5, pages 1284-1297.
Crossref
Simone Mitri, Antônio Fonseca, Ubirani Otero, Marianne Tabalipa, Josino Moreira & Paula Sarcinelli. (2015) Metabolic Polymorphisms and Clinical Findings Related to Benzene Poisoning Detected in Exposed Brazilian Gas-Station Workers. International Journal of Environmental Research and Public Health 12:7, pages 8434-8447.
Crossref
Cristiane Barata-Silva, Simone Mitri, Thelma Pavesi, Enrico Saggioro & Josino Costa Moreira. (2014) Benzeno: reflexos sobre a saúde pública, presença ambiental e indicadores biológicos utilizados para a determinação da exposição. Cadernos Saúde Coletiva 22:4, pages 329-342.
Crossref
Jie Zhu, Zhuoyue Bi, Tan Yang, Wei Wang, Zhen Li, Wenting Huang, Liping Wang, Shaozun Zhang, Yanfeng Zhou, Ningna Fan, YuE Bai, Wentao Song, Chunhong Wang, Hong Wang & Yongyi Bi. (2014) Regulation of PKM2 and Nrf2-ARE Pathway during Benzoquinone Induced Oxidative Stress in Yolk Sac Hematopoietic Stem Cells. PLoS ONE 9:12, pages e113733.
Crossref
Fábio Santiago, Gilda Alves, Ubirani Barros Otero, Marianne Medeiros Tabalipa, Luciano Rios Scherrer, Nadezda Kosyakova, Maria Helena Ornellas & Thomas Liehr. (2014) Monitoring of gas station attendants exposure to benzene, toluene, xylene (BTX) using three-color chromosome painting. Molecular Cytogenetics 7:1.
Crossref
Nada O.F. Kassem, Noura O. Kassem, Sheila R. Jackson, Sandy Liles, Reem M. Daffa, Adam T. Zarth, Maram A. Younis, Steven G. Carmella, C. Richard Hofstetter, Dale A. Chatfield, Georg E. Matt, Stephen S. Hecht & Melbourne F. Hovell. (2014) Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications. Cancer Epidemiology, Biomarkers & Prevention 23:12, pages 2793-2809.
Crossref
G. De Palma & M. Manno. (2014) Metabolic polymorphisms and biomarkers of effect in the biomonitoring of occupational exposure to low-levels of benzene: State of the art. Toxicology Letters 231:2, pages 194-204.
Crossref
Damiano Carbonari, Annarita Proietto, Marzia Fioretti, Giovanna Tranfo, Enrico Paci, Maddalena Papacchini & Antonella Mansi. (2014) Influence of genetic polymorphism on t,t-MA/S-PMA ratio in 301 benzene exposed subjects. Toxicology Letters 231:2, pages 205-212.
Crossref
Rui Xiong, David Siegel & David Ross. (2014) Quinone-induced protein handling changes: Implications for major protein handling systems in quinone-mediated toxicity. Toxicology and Applied Pharmacology 280:2, pages 285-295.
Crossref
Yan Sha, Wei Zhou, Zhenyu Yang, Xiaoling Zhu, Yingping Xiang, Tiandi Li, Dexiang Zhu & Xinyue Yang. (2014) Changes in Poly(ADP-Ribosyl)ation Patterns in Workers Exposed to BTX. PLoS ONE 9:9, pages e106146.
Crossref
Cliona M. McHale, Martyn T. Smith & Luoping Zhang. (2014) Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human. Annals of the New York Academy of Sciences 1310:1, pages 74-83.
Crossref
Jun Yong Choi, Claudia M. Calvet, Shamila S. Gunatilleke, Claudia Ruiz, Michael D. Cameron, James H. McKerrow, Larissa M. Podust & William R. Roush. (2013) Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents. Journal of Medicinal Chemistry 56:19, pages 7651-7668.
Crossref
Ying-Jung Chen & Long-Sen Chang. (2013) Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl. Biochemical Pharmacology 86:5, pages 620-631.
Crossref
Wen-Hsin Liu, Wen-Min Chou & Long-Sen Chang. (2013) p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis 34:4, pages 818-827.
Crossref
S. M. Rappaport, S. Kim, R. Thomas, B. A. Johnson, F. Y. Bois & L. L. Kupper. (2012) Low-dose metabolism of benzene in humans: science and obfuscation. Carcinogenesis 34:1, pages 2-9.
Crossref
Fatemeh Zolghadr, Majid Sadeghizadeh, Naser Amirizadeh, Saman Hosseinkhani & Shima Nazem. (2012) How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicology Letters 214:2, pages 145-153.
Crossref
Liping Wang, Xiaoqing He, Yongyi Bi & Qiang Ma. (2012) Stem Cell and Benzene-Induced Malignancy and Hematotoxicity. Chemical Research in Toxicology 25:7, pages 1303-1315.
Crossref
Ji-Sook Lee, Eun Ju Yang & In Sik Kim. (2012) Hydroquinone-induced apoptosis of human lymphocytes through caspase 9/3 pathway. Molecular Biology Reports 39:6, pages 6737-6743.
Crossref
D Peng, W Jiaxing, H Chunhui, P Weiyi & W Xiaomin. (2012) Study on the cytogenetic changes induced by benzene and hydroquinone in human lymphocytes. Human & Experimental Toxicology 31:4, pages 322-335.
Crossref
E. W. Y. Tung, N. A. Philbrook, K. D. D. MacDonald & L. M. Winn. (2012) DNA Double-Strand Breaks and DNA Recombination in Benzene Metabolite-Induced Genotoxicity. Toxicological Sciences 126:2, pages 569-577.
Crossref
Sabrina Angelini, Francesca Maffei, Justo Lorenzo Bermejo, Gloria Ravegnini, Domenica L’Insalata, Giorgio Cantelli-Forti, Francesco Saverio Violante & Patrizia Hrelia. (2012) Environmental exposure to benzene, micronucleus formation and polymorphisms in DNA-repair genes: A pilot study. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 743:1-2, pages 99-104.
Crossref
Michele Carugno, Angela Cecilia Pesatori, Laura Dioni, Mirjam Hoxha, Valentina Bollati, Benedetta Albetti, Hyang-Min Byun, Matteo Bonzini, Silvia Fustinoni, Pierluigi Cocco, Giannina Satta, Mariagrazia Zucca, Domenico Franco Merlo, Massimo Cipolla, Pier Alberto Bertazzi & Andrea Baccarelli. (2012) Increased Mitochondrial DNA Copy Number in Occupations Associated with Low-Dose Benzene Exposure. Environmental Health Perspectives 120:2, pages 210-215.
Crossref
C. M. McHale, L. Zhang & M. T. Smith. (2011) Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis 33:2, pages 240-252.
Crossref
Ashley A. Fisher, Matthew T. Labenski, Srinivas Malladi, John D. Chapman, Shawn B. Bratton, Terrence J. Monks & Serrine S. Lau. (2011) The Frequency of 1,4-Benzoquinone-Lysine Adducts in Cytochrome c Correlate with Defects in Apoptosome Activation. Toxicological Sciences 122:1, pages 64-72.
Crossref
Martyn T. Smith, Luoping Zhang, Cliona M. McHale, Christine F. Skibola & Stephen M. Rappaport. (2011) Benzene, the exposome and future investigations of leukemia etiology. Chemico-Biological Interactions 192:1-2, pages 155-159.
Crossref
Mahendra P. Singh, M. Mishra, A. Sharma, A.K. Shukla, M.K.R. Mudiam, D.K. Patel, K. Ravi Ram & D. Kar Chowdhuri. (2011) Genotoxicity and apoptosis in Drosophila melanogaster exposed to benzene, toluene and xylene: Attenuation by quercetin and curcumin. Toxicology and Applied Pharmacology 253:1, pages 14-30.
Crossref
Yeshvandra Verma & S.V.S. Rana. (2011) Modulation of phase-II enzyme activities in benzene treated ovariectomized rats. Environmental Toxicology and Pharmacology 31:3, pages 371-377.
Crossref
Takuro Nishikawa, Kimiko Izumo, Emiko Miyahara, Masahisa Horiuchi, Yasuhiro Okamoto, Yoshifumi Kawano & Toru Takeuchi. (2011) Benzene Induces Cytotoxicity without Metabolic Activation. Journal of Occupational Health 53:2, pages 84-92.
Crossref
Valentina Rubio, Jiawei Zhang, Mahara Valverde, Emilio Rojas & Zheng-Zheng Shi. (2011) Essential role of Nrf2 in protection against hydroquinone- and benzoquinone-induced cytotoxicity. Toxicology in Vitro 25:2, pages 521-529.
Crossref
K. H. Barry, Y. Zhang, Q. Lan, S. H. Zahm, T. R. Holford, B. Leaderer, P. Boyle, H. D. Hosgood, S. Chanock, M. Yeager, N. Rothman & T. Zheng. (2011) Genetic Variation in Metabolic Genes, Occupational Solvent Exposure, and Risk of Non-Hodgkin Lymphoma. American Journal of Epidemiology 173:4, pages 404-413.
Crossref
Sabrina Angelini, Rajiv Kumar, Justo Lorenzo Bermejo, Francesca Maffei, Anna Barbieri, Francesca Graziosi, Fabio Carbone, Giorgio Cantelli-Forti, Francesco Saverio Violante, Kari Hemminki & Patrizia Hrelia. (2011) Exposure to low environmental levels of benzene: Evaluation of micronucleus frequencies and S-phenylmercapturic acid excretion in relation to polymorphisms in genes encoding metabolic enzymes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 719:1-2, pages 7-13.
Crossref
Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks & Serrine S. Lau. 2011. Drug Safety Evaluation. Drug Safety Evaluation 317 326 .
Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks & Serrine S. Lau. 2011. Drug Safety Evaluation. Drug Safety Evaluation 303 316 .
H. Zhou, D. Dehn, J. K. Kepa, D. Siegel, D. E. Scott, W. Tan & D. Ross. (2010) NAD(P)H:quinone Oxidoreductase 1-Compromised Human Bone Marrow Endothelial Cells Exhibit Decreased Adhesion Molecule Expression and CD34+ Hematopoietic Cell Adhesion. Journal of Pharmacology and Experimental Therapeutics 334:1, pages 260-268.
Crossref
Martyn T. Smith. (2010) Advances in Understanding Benzene Health Effects and Susceptibility. Annual Review of Public Health 31:1, pages 133-148.
Crossref
M.G. Bird, B.A. Wetmore, D.J. Letinski, M. Nicolich, M. Chen, A.R. Schnatter & F.T. Whitman. (2010) Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures. Chemico-Biological Interactions 184:1-2, pages 233-239.
Crossref
P.J. Kerzic, W.S. Liu, M.T. Pan, H. Fu, Y. Zhou, A.R. Schnatter & R.D. Irons. (2010) Analysis of hydroquinone and catechol in peripheral blood of benzene-exposed workers. Chemico-Biological Interactions 184:1-2, pages 182-188.
Crossref
David Ross & Hongfei Zhou. (2010) Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity. Chemico-Biological Interactions 184:1-2, pages 222-228.
Crossref
Benjamin Smith, Peter Cadby, Michael DiNovi & R. Woodrow Setzer. (2010) Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic. Food and Chemical Toxicology 48, pages S49-S56.
Crossref
Hongfei Zhou, Jadwiga K. Kepa, David Siegel, Shigenori Miura, Yuji Hiraki & David Ross. (2009) Benzene Metabolite Hydroquinone Up-Regulates Chondromodulin-I and Inhibits Tube Formation in Human Bone Marrow Endothelial Cells. Molecular Pharmacology 76:3, pages 579-587.
Crossref
Perrine Hoet, Erika De Smedt, Massimo Ferrari, Marcello Imbriani, Luciano Maestri, Sara Negri, Peter De Wilde, Dominique Lison & Vincent Haufroid. (2008) Evaluation of urinary biomarkers of exposure to benzene: correlation with blood benzene and influence of confounding factors. International Archives of Occupational and Environmental Health 82:8, pages 985-995.
Crossref
Jung-Yeon Yi, Yoko Hirabayashi, Yang-Kyu Choi, Yukio Kodama, Jun Kanno, Jeong-Hee Han, Tohru Inoue & Byung-Il Yoon. (2009) Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene. Archives of Toxicology 83:8, pages 795-803.
Crossref
Z. Ji, L. Zhang, W. Guo, C. M. McHale & M. T. Smith. (2009) The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells. Mutagenesis 24:4, pages 367-372.
Crossref
Luz Stella Hoyos-Giraldo, Silvio Carvajal, Nohelia Cajas-Salazar, Martín Ruíz & Adalberto Sánchez-Gómez. (2009) Chromosome aberrations in workers exposed to organic solvents: Influence of polymorphisms in xenobiotic-metabolism and DNA repair genes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 666:1-2, pages 8-15.
Crossref
Bernard D. Goldstein & Gisela Witz. 2009. Environmental Toxicants. Environmental Toxicants 459 498 .
J. E. Deweese & N. Osheroff. (2008) The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Research 37:3, pages 738-748.
Crossref
Qing Lan, Luoping Zhang, Min Shen, William J. Jo, Roel Vermeulen, Guilan Li, Christopher Vulpe, Sophia Lim, Xuefeng Ren, Stephen M. Rappaport, Sonja I. Berndt, Meredith Yeager, Jeff Yuenger, Richard B. Hayes, Martha Linet, Songnian Yin, Stephen Chanock, Martyn T. Smith & Nathaniel Rothman. (2009) Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis 30:1, pages 50-58.
Crossref
Pin Sun, Ji Qian, Zhong-bin Zhang, Jun-xiang Wan, Fen Wu, Xi-peng Jin, Wei-wei Fan, Da-ru Lu, Nai-qing Zhao, David C. Christiani & Zhao-lin Xia. (2008) Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. Carcinogenesis 29:12, pages 2325-2329.
Crossref
Fen Wu, Zhongbin Zhang, Junxiang Wan, Shouyong Gu, Weiwei Liu, Xipeng Jin & Zhaolin Xia. (2008) Genetic polymorphisms in hMTH1, hOGG1 and hMYH and risk of chronic benzene poisoning in a Chinese occupational population. Toxicology and Applied Pharmacology 233:3, pages 447-453.
Crossref
S Wilbur, D Wohlers, S Paikoff, LS Keith & O Faroon. (2008) ATSDR evaluation of health effects of benzene and relevance to public health. Toxicology and Industrial Health 24:5-6, pages 263-398.
Crossref
Barbara A. Wetmore, Melanie F. Struve, Pu Gao, Sheela Sharma, Neil Allison, Kay C. Roberts, Daniel J. Letinski, Mark J. Nicolich, Michael G. Bird & David C. Dorman. (2008) Genotoxicity of intermittent co-exposure to benzene and toluene in male CD-1 mice. Chemico-Biological Interactions 173:3, pages 166-178.
Crossref
Han-Jin ParkJung Hwa OhSeokjoo YoonS.V.S. Rana. (2008) Time Dependent Gene Expression Changes in the Liver of Mice Treated with Benzene. Biomarker Insights 3, pages BMI.S590.
Crossref
Ryan P. Bender & Neil Osheroff. 2008. Checkpoint Responses in Cancer Therapy. Checkpoint Responses in Cancer Therapy 57 91 .
Sungkyoon Kim, Qing Lan, Suramya Waidyanatha, Stephen Chanock, Brent A. Johnson, Roel Vermeulen, Martyn T. Smith, Luoping Zhang, Guilan Li, Min Shen, Songnian Yin, Nathaniel Rothman & Stephen M. Rappaport. (2007) Genetic polymorphisms and benzene metabolism in humans exposed to a wide Range of air concentrations. Pharmacogenetics and Genomics 17:10, pages 789-801.
Crossref
Ashley A. Fisher, Matthew T. Labenski, Srinivas Malladi, Vijay Gokhale, Martina E. Bowen, Rania S. Milleron, Shawn B. Bratton, Terrence J. Monks & Serrine S. Lau. (2007) Quinone Electrophiles Selectively Adduct “Electrophile Binding Motifs” within Cytochrome c . Biochemistry 46:39, pages 11090-11100.
Crossref
Pin Sun, Zhongbin Zhang, Fen Wu, Junxiang Wan, Xibeng Jin & Zhaolin Xia. (2007) Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning. Frontiers of Medicine in China 1:3, pages 320-326.
Crossref
Ryan P. Bender & Neil Osheroff. (2007) Mutation of Cysteine Residue 455 to Alanine in Human Topoisomerase IIα Confers Hypersensitivity to Quinones:  Enhancing DNA Scission by Closing the N-Terminal Protein Gate. Chemical Research in Toxicology 20:6, pages 975-981.
Crossref
Eliška Kondrová, Pavel Stopka & Pavel Souček. (2007) Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes. Toxicology in Vitro 21:4, pages 566-575.
Crossref
Bennett Ma, Brian A. Carr, Paul Krolikowski & Frank N. Chang. (2006) Cytotoxicity of a Quinone-containing Cockroach Sex Pheromone in Human Lung Adenocarcinoma Cells. Chemical Research in Toxicology 20:1, pages 72-78.
Crossref
Helen J. Badham & Louise M. Winn. (2007) Investigating the role of the aryl hydrocarbon receptor in benzene-initiated toxicity in vitro. Toxicology 229:3, pages 177-185.
Crossref
DANA B. MIRKIN. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 1363 1376 .
Guang-Xun Li, Yoko Hirabayashi, Byung-Il Yoon, Yasushi Kawasaki, Isao Tsuboi, Yukio Kodama, Yuji Kurokawa, Junji Yodoi, Jun Kanno & Tohru Inoue. (2006) Thioredoxin overexpression in mice, model of attenuation of oxidative stress, prevents benzene-induced hemato-lymphoid toxicity and thymic lymphoma. Experimental Hematology 34:12, pages 1687-1697.
Crossref
Sungkyoon Kim, Roel Vermeulen, Suramya Waidyanatha, Brent A. Johnson, Qing Lan, Martyn T. Smith, Luoping Zhang, Guilan Li, Min Shen, Songnian Yin, Nathaniel Rothman & Stephen M. Rappaport. (2006) Modeling Human Metabolism of Benzene Following Occupational and Environmental Exposures. Cancer Epidemiology, Biomarkers & Prevention 15:11, pages 2246-2252.
Crossref
Zhongbin Zhang, Junxiang Wan, Xipeng Jin, Taiyi Jin, Hongbing Shen, Daru Lu & Zhaolin Xia. (2005) Genetic Polymorphisms in XRCC1, APE1, ADPRT, XRCC2 , and XRCC3 and Risk of Chronic Benzene Poisoning in a Chinese Occupational Population . Cancer Epidemiology, Biomarkers & Prevention 14:11, pages 2614-2619.
Crossref
Kun-Ming Chen, Karam El-Bayoumy, James Hosey, John Cunningham, Cesar Aliaga & Assieh A. Melikian. (2005) Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice. Chemico-Biological Interactions 156:2-3, pages 81-91.
Crossref
Ruben Ruiz-Ramos, Mariano E. Cebrian & Efraín Garrido. (2005) Benzoquinone activates the ERK/MAPK signaling pathway via ROS production in HL-60 cells. Toxicology 209:3, pages 279-287.
Crossref
R. Hunter Lindsey, Ryan P. Bender & Neil Osheroff. (2005) Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chemico-Biological Interactions 153-154, pages 197-205.
Crossref
Andrew T. Vaughan, Christopher J. Betti, Michael J. Villalobos, Kumpati Premkumar, Edith Cline, Qun Jiang & Manuel O. Diaz. (2005) Surviving apoptosis: A possible mechanism of benzene-induced leukemia. Chemico-Biological Interactions 153-154, pages 179-185.
Crossref
Leslie Recio, Alison Bauer & Brenda Faiola. (2005) Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity. Chemico-Biological Interactions 153-154, pages 159-164.
Crossref
David Ross. (2005) Functions and distribution of NQO1 in human bone marrow: Potential clues to benzene toxicity. Chemico-Biological Interactions 153-154, pages 137-146.
Crossref
R. Hunter Lindsey, Ryan P. Bender & Neil Osheroff. (2005) Effects of Benzene Metabolites on DNA Cleavage Mediated by Human Topoisomerase IIα:  1,4-Hydroquinone Is a Topoisomerase II Poison. Chemical Research in Toxicology 18:4, pages 761-770.
Crossref
Daiva Bironaite, David Siegel, Julie L. Moran, Babette B. Weksler & David Ross. (2004) Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Chemico-Biological Interactions 149:2-3, pages 177-188.
Crossref
Brenda Faiola, Elizabeth S. Fuller, Victoria A. Wong, Linda Pluta, Diane J. Abernethy, Jason Rose & Leslie Recio. (2008) Exposure of Hematopoietic Stem Cells to Benzene or 1,4‐Benzoquinone Induces Gender‐Specific Gene Expression. STEM CELLS 22:5, pages 750-758.
Crossref
Daiva Bironaite, David Siegel, Julie L. Moran, Babette B. Weksler & David Ross. (2004) Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Chemico-Biological Interactions 149:1, pages 37-49.
Crossref
Su Young Kim, Jung Keun Choi, Yoon Hee Cho, Eun Jung Chung, Domyung Paek & Hai Won Chung. (2004) Chromosomal aberrations in workers exposed to low levels of benzene. Pharmacogenetics 14:7, pages 453-463.
Crossref
R. Hunter Lindsey,, Kenneth D. Bromberg, Carolyn A. Felix & Neil Osheroff. (2004) 1,4-Benzoquinone Is a Topoisomerase II Poison. Biochemistry 43:23, pages 7563-7574.
Crossref
Brenda Faiola, Elizabeth S Fuller, Victoria A Wong & Leslie Recio. (2004) Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 549:1-2, pages 195-212.
Crossref
K.-M. Chen, K. El-Bayoumy, J. Cunningham, C. Aliaga, H. Li & A. A. Melikian. (2004) Detection of Nitrated Benzene Metabolites in Bone Marrow of B6C3F 1 Mice Treated with Benzene . Chemical Research in Toxicology 17:3, pages 370-377.
Crossref
David Ross & David Siegel. 2004. Quinones and Quinone Enzymes, Part B. Quinones and Quinone Enzymes, Part B 115 144 .
G. Elizondo & F. J. Gonzalez. 2004. Transgenic Models in Pharmacology. Transgenic Models in Pharmacology 639 660 .
Alejandra Picazo & Roberto Salcedo. (2003) Carcinogenic activity in estrone and its derivatives: a theoretical study. Journal of Molecular Structure: THEOCHEM 624:1-3, pages 29-36.
Crossref
Salmaan H. Inayat-Hussain, Shannon L. Winski & David Ross. (2001) Differential Involvement of Caspases in Hydroquinone-Induced Apoptosis in Human Leukemic HL-60 and Jurkat Cells. Toxicology and Applied Pharmacology 175:2, pages 95-103.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.