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Journal of Toxicology and Environmental Health Volume 52, 1997 - Issue 4

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AMIODARONE-INDUCED PULMONARY TOXICITY IN FISCHER RATS: RELEASE OF TUMOR NECROSIS FACTOR ALPHA AND TRANSFORMING GROWTH FACTOR BETA BY PULMONARY ALVEOLAR MACROPHAGES

Paul G. Reinhart Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, USAView further author information

C. Gary Gairola Graduate Center for Toxicology and College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA

Pages 353-365 | Received 12 Nov 1996, Accepted 25 Feb 1997, Published online: 25 Sep 2007

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Inas Harb, Hend Ashour, Laila A. Rashed, Abeer Mostafa, Mai Samir, Basma Emad Aboulhoda, Hala El‐hanbuli, Eman Rashwan & Heba Mahmoud. (2022) Nicorandil mitigates amiodarone‐induced pulmonary toxicity and fibrosis in association with the inhibition of lung TGF ‐β1/ PI3K /Akt1‐p/ mTOR axis in rats . Clinical and Experimental Pharmacology and Physiology 50:1, pages 96-106.
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Shuchan Li, Jianrong Shi & Huifang Tang. (2021) Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics. Cell Biology and Toxicology 38:5, pages 699-723.
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Sara Al‐Hassan, Hala Attia, Hatun Alomar, Maha Arafa & Rehab A. Ali. (2021) The inhibitory mechanisms of losartan and vitamin D on amiodarone‐induced lung inflammation in rats: Role of mitogen‐activated protein kinases/activator protein‐1. Journal of Biochemical and Molecular Toxicology 35:12.
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Marianna M. Henry & Terry L. Noah. 2019. Kendig's Disorders of the Respiratory Tract in Children. Kendig's Disorders of the Respiratory Tract in Children 876 885.e6 .

Hamid-Reza Nasri, Siyavash Joukar, Hamid Kheradmand, Hamid-Reza Poursalehi & Shahriar Dabiri. (2016) Coadministration of Atorvastatin and Amiodarone Increases the Risk of Pulmonary Fibrosis in Rats. Medical Principles and Practice 25:2, pages 150-154.
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Kei Yamasaki, Kazuhiro Yatera, Shingo Noguchi, Keishi Oda, Kentarou Akata, Chinatsu Nishida, Toshinori Kawanami, Yukiko Kawanami, Hiroshi Ishimoto, Shiro Ono, Yukio Wakuta & Hiroshi Mukae. (2013) Incidence and outcomes of bepridil-induced interstitial pneumonia. Respiratory Medicine 107:12, pages 2088-2091.
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Kang-Yo Lee, Sehee Oh, You-Jin Choi, Seon-Hee Oh, Young-Su Yang, Mi-Jin Yang, Kyuhong Lee & Byung-Hoon Lee. (2013) Activation of Autophagy Rescues Amiodarone-Induced Apoptosis of Lung Epithelial Cells and Pulmonary Toxicity in Rats. Toxicological Sciences 136:1, pages 193-204.
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Theodore E. Van Cott, Karen S. Yehle, Susan K. DeCrane & Janet R. Thorlton. (2013) Amiodarone-induced pulmonary toxicity: Case study with syndrome analysis. Heart & Lung 42:4, pages 262-266.
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Jingtao Lu, A. Daniel Jones, Jack R. Harkema, Robert A. Roth & Patricia E. Ganey. (2012) Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha. Toxicological Sciences 125:1, pages 126-133.
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Spyros A. Papiris, Christina Triantafillidou, Likurgos Kolilekas, Despoina Markoulaki & Effrosyni D. Manali. (2010) Amiodarone. Drug Safety 33:7, pages 539-558.
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Tadao Kuruma, Toru Maruyama, Shin-ichi Hiramatsu, Yuichiro Yasuda, Shioto Yasuda, Keita Odashiro & Mine Harada. (2009) Relationship between amiodarone-induced subclinical lung toxicity and Th1/Th2 balance. International Journal of Cardiology 134:2, pages 224-230.
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Durairaj Punithavathi, Narayanan Venkatesan & Mary Babu. (2009) Protective effects of curcumin against amiodarone‐induced pulmonary fibrosis in rats. British Journal of Pharmacology 139:7, pages 1342-1350.
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Michael D Taylor, James M Antonini, Jenny R Roberts, Stephen S Leonard, Xianglin Shi, Peter M Gannett, Ann F Hubbs & Mark J Reasor. (2003) Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells. Toxicology and Applied Pharmacology 188:2, pages 92-103.
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Bruce D. Uhal, Rongqi Wang, Jeremy Laukka, Jiaju Zhuang, Valerie Soledad‐Conrad & Gerasimos Filippatos. (2003) Inhibition of Amiodarone‐Induced Lung Fibrosis but not Alveolitis by Angiotensin System Antagonists. Pharmacology & Toxicology 92:2, pages 81-87.
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M Firoze Khan, Xiaohong Wu & Jianling Wang. (2003) Up-regulation of transforming growth factor-β1 in the spleen of aniline-treated rats. Toxicology and Applied Pharmacology 187:1, pages 22-28.
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Aldo Baritussio, Stefano Marzini, Marco Agostini, Antonella Alberti, Cristina Cimenti, Daniela Bruttomesso, Enzo Manzato, Daniela Quaglino & Andrea Pettenazzo. (2001) Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes. American Journal of Physiology-Lung Cellular and Molecular Physiology 281:5, pages L1189-L1199.
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William H. Chung, Brian M. Bennett, William J. Racz, James F. Brien & Thomas E. Massey. (2001) Induction of c- jun and TGF-β1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis . American Journal of Physiology-Lung Cellular and Molecular Physiology 281:5, pages L1180-L1188.
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Michael D. Taylor, Knox Van Dyke, Linda L. Bowman, Philip R. Miles, Ann F. Hubbs, Robert J. Mason, Kathy Shannon & Mark J. Reasor. (2000) A Characterization of Amiodarone-Induced Pulmonary Toxicity in F344 Rats and Identification of Surfactant Protein-D as a Potential Biomarker for the Development of the Toxicity. Toxicology and Applied Pharmacology 167:3, pages 182-190.
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F. Carrión Valero & J. Marín Pardo. (1999) Toxicidad pulmonar por fármacos. Archivos de Bronconeumología 35:11, pages 550-559.
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Chihaya Kakinuma, Yoshimasa Hamada, Yoshihiro Futamura, Chitose Kuwayama, Akihito Shimoi & Yasunori Shibutani. (2016) Human Natural Tumor Necrosis Factor α Induces Multiple Endocrine and Hematologic Disorders in Rats. Toxicologic Pathology 27:4, pages 402-411.
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Hakan Oral, Susan G Fisher, William P Fay, Steven N Singh, Ross D Fletcher & Fred Morady. (1999) Effects of amiodarone on tumor necrosis factor-α levels in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. The American Journal of Cardiology 83:3, pages 388-391.
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AMIODARONE-INDUCED PULMONARY TOXICITY IN FISCHER RATS: RELEASE OF TUMOR NECROSIS FACTOR ALPHA AND TRANSFORMING GROWTH FACTOR BETA BY PULMONARY ALVEOLAR MACROPHAGES

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AMIODARONE-INDUCED PULMONARY TOXICITY IN FISCHER RATS: RELEASE OF TUMOR NECROSIS FACTOR ALPHA AND TRANSFORMING GROWTH FACTOR BETA BY PULMONARY ALVEOLAR MACROPHAGES

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