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Bishwajit Das & Durjoy Majumder. (2023) A molecular docking-based comparative assessment of various anticholinergic drugs as antidotes to different nerve agent poisoning. Journal of Biomolecular Structure and Dynamics 41:16, pages 7809-7820.
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Kamil Kuca, Gupta RC, Kamil Musilek, Daniel Jun & Miroslav Pohanka. (2009) In vitro identification of novel acetylcholinesterase reactivators. Toxin Reviews 28:4, pages 238-244.
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Jiri Kassa, Jana Zdarova Karasova, Kamil Musilek & Kamil Kuca. (2009) A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice. Toxicology Mechanisms and Methods 19:5, pages 346-350.
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D.E. Lorke, M.Y. Hasan, S.M. Nurulain, K. Kuča, A. Schmitt & G.A. Petroianu. (2009) Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6. Toxicology Mechanisms and Methods 19:4, pages 327-333.
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Jiri Kassa, Jana Karasova, Kamil Musilek, Kamil Kuca & Jiri Bajgar. (2009) An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice. Clinical Toxicology 47:1, pages 72-76.
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Miroslav Pohanka, Daniel Jun & Kamil Kuca. (2008) Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation. Journal of Enzyme Inhibition and Medicinal Chemistry 23:6, pages 781-784.
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Daniel Jun, Kamil Kuca, Jan Picha, Vit Koleckar & Jan Marek. (2008) Potency of Novel Oximes to Reactivate Sarin Inhibited Human Cholinesterases. Drug and Chemical Toxicology 31:1, pages 1-9.
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Miroslav Pohanka, Daniel Jun & Kamil Kuca. (2007) Amperometric Biosensor for Evaluation of Competitive Cholinesterase Inhibition by the Reactivator HI‐6. Analytical Letters 40:12, pages 2351-2359.
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Vesna Jaćević, Jelena Dumanović, Jelica Grujić-Milanović, Zoran Milovanović, Ljiljana Amidžić, Nataša Vojinović, Lana Nežić, Bojan Marković, Vladimir Dobričić, Petar Milosavljević, Eugenie Nepovimova & Kamil Kuča. (2023) Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes. Chemico-Biological Interactions 383, pages 110658.
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Vinduja Vasudevan, Janani Prabaharan, Nagasathiya Krishnan, Abinaya K, Subash C. B. Gopinath & Pachaiappan Raman. (2023)
Metabolite profiling from different parts of tender fruit endosperm of
Borassus flabellifer
L. (ice apple)
. Analytical Methods 15:30, pages 3735-3751.
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Marcelo C. Santos, Fernanda D. Botelho, Arlan S. Gonçalves, Kamil Kuca, Eugenie Nepovimova, Samir F.A. Cavalcante, Antonio L.S. Lima & Tanos C.C. França. (2022) Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok). Food and Chemical Toxicology 165, pages 113084.
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Kamil Musilek, David Malinak, Eugenie Nepovimova, Rudolf Andrys, Adam Skarka & Kamil Kuca. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents
1161
1177
.
Vesna Jaćević, Eugenie Nepovimova & Kamil Kuča. (2019) Interspecies and intergender differences in acute toxicity of K-oximes drug candidates. Chemico-Biological Interactions 308, pages 312-316.
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Kamil Kuca, Eugenie Nepovimova, Qinghua Wu, Felipe Rodrigues de Souza, Teodorico de Castro Ramalho, Tanos Celmar Costa Franca & Kamil Musilek. (2018) Experimental hydrophilic reactivator: bisoxime with three positive charges. Chemical Papers 73:3, pages 777-782.
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Vesna Jaćević, Eugenie Nepovimova & Kamil Kuča. (2019) Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure. Scientific Reports 9:1.
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Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge da Silva, Teodorico Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova & Tanos França. (2018) Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Molecules 23:5, pages 1103.
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Jiří Patočka & Romana Jelínková. (2017) ATROPINE AND ATROPINE-LIKE SUBSTANCES USABLE IN WARFARE. Military Medical Science Letters 86:2, pages 58-69.
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K. Kuca, J. Korabecny, R. Dolezal, E. Nepovimova, O. Soukup, L. Gorecki & K. Musilek. (2017) Tetroxime: reactivation potency – in vitro and in silico study. RSC Advances 7:12, pages 7041-7045.
Crossref
Crossref
A.-C. Cuquel, F. Dorandeu, F. Ceppa, C. Renard & P. Burnat. (2015) Le VR, version russe du neurotoxique organophosphoré VX. Annales Pharmaceutiques Françaises 73:3, pages 180-189.
Crossref
Crossref
Kamil Musilek, Jan Korabecny, Daniel Jun, Jiri Kassa & Kamil Kuca. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents
1071
1087
.
H. Delacour & F. Dorandeu. (2014) Intoxications aigu?s par les agents neurotoxiques organophosphor?s: modalit?s de prise en charge m?dicaleNerve agent-induced acute poisoning: principles of medical management. R?animation 23:S2, pages 458-465.
Crossref
Crossref
O. Soukup, D. Jun, G. Tobin & K. Kuca. (2012) The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors. Archives of Toxicology 87:4, pages 711-719.
Crossref
Crossref
Vasil N. Atanasov, Iskra Petrova & Christophor Dishovsky. (2013) In vitro investigation of efficacy of new reactivators on OPC inhibited rat brain acetylcholinesterase. Chemico-Biological Interactions 203:1, pages 139-143.
Crossref
Crossref
O. Soukup, Z. Kristofikova, D. Jun, V. Tambor, D. Ripova & K. Kuca. (2012) The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers. Toxicology Letters 212:3, pages 315-319.
Crossref
Crossref
Namrata Singh, Kallol K. Ghosh, Jan Marek & Kamil Kuca. (2011) Hydrolysis of carboxylate and phosphate esters using monopyridinium oximes in cationic micellar media. International Journal of Chemical Kinetics 43:10, pages 569-578.
Crossref
Crossref
J. Mikler, C. Tenn, F. Worek, G. Reiter, H. Thiermann, M. Garrett, S. Bohnert & T.W. Sawyer. (2011) Immobilization of Russian VX skin depots by localized cooling: Implications for decontamination and medical countermeasures. Toxicology Letters 206:1, pages 47-53.
Crossref
Crossref
Paul M. Lundy, Murray G. Hamilton, Thomas W. Sawyer & John Mikler. (2011) Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning. Toxicology 285:3, pages 90-96.
Crossref
Crossref
O. Soukup, U.K. Kumar, J. Proska, L. Bratova, A. Adem, D. Jun, J. Fusek, K. Kuca & G. Tobin. (2011) The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations. Environmental Toxicology and Pharmacology 31:3, pages 364-370.
Crossref
Crossref
Daniel Jun, Petr Stodulka, Martina Hrabinova, Miroslav Pohanka, Bohuslav Doleza & Kamil Kuca. (2011) TLC analysis of twelve different salts of oxime HI-6 — Reactivator of nerve agent inhibited AChE. Journal of Planar Chromatography – Modern TLC 24:2, pages 105-107.
Crossref
Crossref
Andrew C. Hemmert, Tamara C. Otto, Roberto A. Chica, Monika Wierdl, Jonathan S. Edwards, Steven L. Lewis, Carol C. Edwards, Lyudmila Tsurkan, C. Linn Cadieux, Shane A. Kasten, John R. Cashman, Stephen L. Mayo, Philip M. Potter, Douglas M. Cerasoli & Matthew R. Redinbo. (2011) Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme. PLoS ONE 6:3, pages e17441.
Crossref
Crossref
Zdeněk Fišar, Jana Hroudová, Jan Korábečný, Kamil Musílek & Kamil Kuča. (2011) In vitro effects of acetylcholinesterase reactivators on monoamine oxidase activity. Toxicology Letters 201:2, pages 176-180.
Crossref
Crossref
Kamil Musilek, Marketa Komloova, Ondrej Holas, Anna Horova, Miroslav Pohanka, Frank Gunn-Moore, Vlastimil Dohnal, Martin Dolezal & Kamil Kuca. (2011) Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage—Preparation, in vitro screening and molecular docking. Bioorganic & Medicinal Chemistry 19:2, pages 754-762.
Crossref
Crossref
Alessandra Antunes Dos Santos, Danúbia Bonfanti Dos Santos, Alcir Luiz Dafre, Andreza Fabro De Bem, Diogo Onofre Souza, João Batista Teixeira Da Rocha, Kamil Kuca & Marcelo Farina. (2010)
In vitro
Reactivating Effects of Standard and Newly Developed Oximes on Malaoxon‐Inhibited Mouse Brain Acetylcholinesterase
. Basic & Clinical Pharmacology & Toxicology 107:3, pages 768-773.
Crossref
Crossref
Ondřej Soukup, Ondřej Holas, Jiří Binder, Kumar Killy, Gunnar Tobin, Daniel Jun, Josef Fusek & Kamil Kuča. (2010) The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder. Journal of Applied Biomedicine 8:2, pages 87-92.
Crossref
Crossref
Ondrej Holas, Kamil Musilek, Miroslav Pohanka, Kamil Kuca, Veronika Opletalova & Young-Sik Jung. (2010) In vitro Screening of Oxime Reactivators on the Model of Paraoxon-inhibited Acetylcholinesterase-SAR Study. Bulletin of the Korean Chemical Society 31:6, pages 1609-1614.
Crossref
Crossref
Jana Žďárová Karasová, Petr Stodůlka & Kamil Kuča. (2010) In vitro screening of blood-brain barrier penetration of clinically used acetylcholinesterase reactivators. Journal of Applied Biomedicine 8:1, pages 35-40.
Crossref
Crossref
Victor A. Voicu, Horst Thiermann, Flavian Ştefan Rădulescu, Constantin Mircioiu & Dalia Simona Miron. (2010)
The Toxicokinetics and Toxicodynamics of Organophosphonates
versus
the Pharmacokinetics and Pharmacodynamics of Oxime Antidotes: Biological Consequences
. Basic & Clinical Pharmacology & Toxicology 106:2, pages 73-85.
Crossref
Crossref
Jana Zdarova Karasova, Jiri Bajgar, Daniel Jun, Ruzena Pavlikova & Kamil Kuca. (2009) Time-Course Changes of Acetylcholinesterase Activity in Blood and Some Tissues in Rats After Intoxication by Russian VX. Neurotoxicity Research 16:4, pages 356-360.
Crossref
Crossref
D. E. Lorke & G. A. Petroianu. (2009)
Minireview: does
in‐vitro
testing of oximes help predict their
in‐vivo
action after paraoxon exposure?
. Journal of Applied Toxicology 29:6, pages 459-469.
Crossref
Crossref
S. M. Nurulain, D. E. Lorke, M. Y. Hasan, M. Shafiullah, K. Kuča, K. Musilek & G. A. Petroianu. (2009) Efficacy of Eight Experimental Bispyridinium Oximes Against Paraoxon-Induced Mortality: Comparison with the Conventional Oximes Pralidoxime and Obidoxime. Neurotoxicity Research 16:1, pages 60-67.
Crossref
Crossref
Kamil Kuca, Kamil Musilek, Daniel Jun, Jiri Bajgar & Jiri Kassa. 2009. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents
997
1021
.
Jana Karasova, Jiri Kassa, Young-Sik Jung, Kamil Musilek, Miroslav Pohanka & Kamil Kuca. (2008) Effect of Several New and Currently Available Oxime Cholinesterase Reactivators on Tabun-intoxicated Rats. International Journal of Molecular Sciences 9:11, pages 2243-2252.
Crossref
Crossref
Miroslav Pohanka, Daniel Jun & Kamil Kuca. (2008) Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. Talanta 77:1, pages 451-454.
Crossref
Crossref
D. E. Lorke, S. M. Nurulain, M. Y. Hasan, K. Kuča, K. Musilek & G. A. Petroianu. (2008)
Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime:
in vivo
efficacy to protect from diisopropylfluorophosphate toxicity
. Journal of Applied Toxicology 28:7, pages 920-928.
Crossref
Crossref
Miroslav Pohanka, Daniel Jun & Kamil Kuca. (2008) Amperometric Biosensors for Real Time Assays of Organophosphates. Sensors 8:9, pages 5303-5312.
Crossref
Crossref
D. E. Lorke, M. Y. Hasan, K. Arafat, K. Kuča, K. Musilek, A. Schmitt & G. A. Petroianu. (2008)
In vitro
oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl‐fluorophosphate
. Journal of Applied Toxicology 28:4, pages 422-429.
Crossref
Crossref
Jiri Kassa, Daniel Jun, Kamil Kuca & Jiri Bajgar. (2007) Comparison of Reactivating and Therapeutic Efficacy of Two Salts of the Oxime HI-6 against Tabun, Soman and Cyclosarin in Rats. Basic & Clinical Pharmacology & Toxicology 101:5, pages 328-332.
Crossref
Crossref
Miroslav Pohanka, Kamil Kuča & Daniel Jun. (2007) Amperometric Biosensor for Pesticide Methamidophos Assay. Acta Medica (Hradec Kralove, Czech Republic) 50:4, pages 239-241.
Crossref
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