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Drug and Chemical Toxicology Volume 45, 2022 - Issue 4
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Research Articles

Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis

Iman O. Sherifa Emergency Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9487-3456View further author information
ORCID Icon &
Nora H. Al-Shaalanb Chemistry Department, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaView further author information
Pages 1723-1731 | Received 14 Apr 2020, Accepted 06 Dec 2020, Published online: 21 Dec 2020

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Mukaddes Gürler, Engin Burak Selçuk, Beyza Güzide Özerol, Kevser Tanbek, Elif Taşlıdere, Azibe Yıldız, Fatma Hilal Yağın & Elif Gürel. (2023) Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats. Drug and Chemical Toxicology 46:4, pages 708-716.
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Jie Yao, Shuming Tang, Chenyan Shi, Yunzhi Lin, Lanlan Ge, Qinghua Chen, Baoru Ou, Dongyu Liu, Yuyang Miao, Qiujie Xie, Xudong Tang, Jia Fei, Guangyi Yang, Jun Tian & Xiaobin Zeng. (2023) Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma. Autophagy 19:4, pages 1221-1238.
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Wenwen Zhao, Bufan Li, Jinjun Hao, Ruochen Sun, Peng He, Hongyu Lv, Mou He, Jie Shen & Yantao Han. (2024) Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm. Pharmacology & Therapeutics, pages 108652.
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Tanveer Ahmed Khan, Muhammad Rizwan Arshad & Muhammad Hamza Ikram. (2024) Phytological facets of extant maidenhair: Gingko biloba Linn. Pharmacy & Pharmacology International Journal 12:1, pages 1-3.
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Jyoti Rani, Sanju Bala Dhull, Pawan Kumar Rose & Mohd. Kashif Kidwai. (2024) Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective. Phytomedicine 122, pages 155142.
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Jing Yu, Jinghui Wang, Jianhua Yang, Ting Ouyang, Honglei Gao, Hongxing Kan & Yinfeng Yang. (2024) New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer. Phytomedicine 122, pages 155088.
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Zhwan Azad Abdalla, Asoo Nihad Abtar, Ahmed Azad Kareem, Zheen Aorahman Ahmed & Tavga Ahmed Aziz. (2023) Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin. Biochemistry and Biophysics Reports 36, pages 101582.
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Zhi Yao, Zhi Feng, Chunwen Wu, Longping Tang, Xiuzhong Wu, Dahua Chen, Qiye Wang, Kaifang Fan, Yiqiang Wang & Meng Li. (2023) Analysis of Genetic Diversity and Construction of a Core Collection of Ginkgo biloba Germplasm Using EST-SSR Markers. Forests 14:11, pages 2155.
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Jacob Wolf, Levi Hoffman & Carl Southern. (2023) Successful Management of Severe Manganese Toxicosis in Two Dogs. Journal of the American Animal Hospital Association 59:3, pages 152-157.
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Qingqing Wang, Zihou Liu, Rui Wang, Run Li, Xiaoru Lian, Yanquan Yang, Jiao Yan, Zhiqi Yin, Guangji Wang, Jianguo Sun & Ying Peng. (2023) Effect of Ginkgo biloba extract on pharmacology and pharmacokinetics of atorvastatin in rats with hyperlipidaemia . Food & Function 14:7, pages 3051-3066.
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Vincent Di Martino, Delphine Weil Verhoeven, Frank Verhoeven, François Aubin, Jérome Avouac, Lucine Vuitton, Frédéric Lioté, Thierry Thévenot & Daniel Wendling. (2022) Busting the myth of methotrexate chronic hepatotoxicity. Nature Reviews Rheumatology 19:2, pages 96-110.
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Al-Abbassi Lahib Mohammed, Sharba Intisar Razzaq & Al-Hatemy Kareem Talib. The protective efficacy of Aloe vera gel against leukopenia and thrombocytopenia caused by (methotrexate and azathioprine) drugs. The protective efficacy of Aloe vera gel against leukopenia and thrombocytopenia caused by (methotrexate and azathioprine) drugs.
Xue Sun, Yiming Zhu, Fang Li, Min Li & Guoxing Wan. (2022) Cardioprotective Mechanism and Active Compounds of Folium Ginkgo on Adriamycin-Induced Cardiotoxicity: A Network Pharmacology Study. Computational and Mathematical Methods in Medicine 2022, pages 1-10.
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Manal A. Alfwuaires. (2021) Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity. Environmental Science and Pollution Research 29:14, pages 20279-20288.
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Ewa Kilanczyk, Jesus M. Banales, Ewelina Jurewicz, Piotr Milkiewicz & Malgorzata Milkiewicz. (2021) p-STAT3 is a PDC-E2 interacting partner in human cholangiocytes and hepatocytes with potential pathobiological implications. Scientific Reports 11:1.
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