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Original Articles

Direct Liquid Chromatographic Resolution of Acidic Drugs Using a Chiral α1-Acid Glycoprotein Column (Enantiopac®)

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Pages 621-639 | Published online: 19 Dec 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (24)

Fotios Tsopelas, Constantinos Giaginis & Anna Tsantili-Kakoulidou. (2017) Lipophilicity and biomimetic properties to support drug discovery. Expert Opinion on Drug Discovery 12:9, pages 885-896.
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PrakashM. Davadra, SnehalJ. Patel, MukulR. Jain, PankajR. Patel, HitendraS. Joshi & AtulH. Bapodra. (2011) A VALIDATED CHIRAL RP-HPLC METHOD FOR THE ENANTIOMERIC SEPARATION OF DULOXETINE HYDROCHLORIDE USING CHIRAL-AGP AS THE STATIONARY PHASE. Journal of Liquid Chromatography & Related Technologies 34:16, pages 1699-1711.
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Guy Felix & Alain Berthod. (2008) Part II: From Dermatologicals to Sensory Organ and Various Drugs. Separation & Purification Reviews 37:1-2, pages 1-227.
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Guy Felix & Alain Berthod. (2007) Commercial Chiral Stationary Phases for the Separations of Clinical Racemic Drugs. Separation & Purification Reviews 36:4, pages 285-481.
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Richard Thompson. (2005) A Practical Guide to HPLC Enantioseparations for Pharmaceutical Compounds. Journal of Liquid Chromatography & Related Technologies 28:7-8, pages 1215-1231.
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R. Thompson, V. Prasad, N. Grinberg, D. Ellison & J. Wyvratt. (2001) MECHANISTIC ASPECTS OF THE STEREOSPECIFIC INTERACTIONS OF IMMOBILIZED α1-ACID GLYCOPROTEIN. Journal of Liquid Chromatography & Related Technologies 24:6, pages 813-825.
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Ahsanul Haque & JamesT. Stewart. (1998) Chiral Separations of Selected Pharmaceuticals on Avidin Column. Journal of Liquid Chromatography & Related Technologies 21:17, pages 2675-2687.
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Gy. Szász, K. Gyimesi-Forrás & Zs. Budvári-Bárány. (1998) Optimized and Validated HPLC Methods for Compendial Quality Assessment. III. Testing of Optical Purity Applying α1-Acid-Glycoprotein Stationary Phase. Journal of Liquid Chromatography & Related Technologies 21:16, pages 2535-2547.
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Chun-Sheng Chang & Shau-Wei Tsai. (1998) Enantioselective Adsorption of (+)-(S)-Naproxen in a Crosslinked Lipase in Organic Solvents. Separation Science and Technology 33:14, pages 2113-2122.
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A. Van Overbeke, W. Baeyens & C. Dewaele. (1995) Comparative Study on the Enantiomeric Separation of Several Non-Steroidal Anti-Inflammatory Drugs on Two Cellulose-Based Chiral Stationary Phases. Journal of Liquid Chromatography 18:12, pages 2427-2443.
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L. Castellani, M. Flieger & M. Sinibaldi. (1994) Enantiomer Separation of 2-Arylpropionic Acids on an Ergot Alkaloid-Based Stationary Phase Microbore Column Application. Journal of Liquid Chromatography 17:17, pages 3695-3703.
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M.H. Hyun, S.M. Cho, J.-J. Ryoo & M.S. Kim. (1994) A Mechanistic Evaluation for the Resolution of Enantiomers of α-Arylpropionic Acid Derivatives on π-Basic Chiral Stationary Phases. Journal of Liquid Chromatography 17:2, pages 317-328.
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H. Fujima, H. Wada, T. Miwa & J. Haginaka. (1993) Chiral Separation of Lorazepam on Ovomucoid-Bonded Columns: Peak Coalescence Due to Racemization. Journal of Liquid Chromatography 16:4, pages 879-891.
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R.C. Williams, J.F. Edwards & M.J. Potter. (1993) Retention Characteristics of Protein-Based Chiral HPLC Columns. Journal of Liquid Chromatography 16:1, pages 171-196.
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HassanY. Aboul-Enein & SolimanA. Bakr. (1992) Simple Chiral Liquid Chromatographic Separation of Flurbiprofen Enantiomers in Biological Fluids. Journal of Liquid Chromatography 15:11, pages 1983-1992.
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WilliamH. Pirkle & ChristopherJ. Welch. (1991) Chromatographic Separation of Underivatized Naproxen Enantiomers. Journal of Liquid Chromatography 14:18, pages 3387-3396.
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J. Zukowski & R. Nowakowski. (1989) Dynamically Generated Chiral Stationary Phase Systems with β-Cyclodextrin Derivatives. Journal of Liquid Chromatography 12:9, pages 1545-1569.
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Yoshio Okamoto, Ryo Aburatani, Kazuhiro Hatano & Koichi Hatada. (1988) Optical Resolution of Racemic Drugs by Chiral HPLC on Cellulose and Amylose Tris(phenylcarbamate) Derivatives. Journal of Liquid Chromatography 11:9-10, pages 2147-2163.
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Daniel W. Armstrong, Soon M. Han & Willie L. Hinze. (1988) Enantiomeric Separations in Chromatography. C R C Critical Reviews in Analytical Chemistry 19:3, pages 175-224.
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Takashi Michishita, Pilar Franco & Tong Zhang. (2010) New approaches of LC‐MS compatible method development on α 1 ‐acid glycoprotein‐based stationary phase for resolution of enantiomers by HPLC . Journal of Separation Science 33:23-24, pages 3627-3637.
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Torgny Fornstedt. (2010) Characterization of adsorption processes in analytical liquid–solid chromatography. Journal of Chromatography A 1217:6, pages 792-812.
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Francesco Barbato, Carmen Carpentiero, Lucia Grumetto & Maria Immacolata La Rotonda. (2009) Enantioselective retention of β-blocking agents on human serum albumin and α1-acid glycoprotein HPLC columns: Relationships with different scales of lipophilicity. European Journal of Pharmaceutical Sciences 38:5, pages 472-478.
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