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Journal of Liquid Chromatography Volume 14, 1991 - Issue 4
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Original Articles

HPLC Separation of Taxol and Cephalomannine

John H. Cardellina II Laboratory of Drug Discovery Research, Development National Cancer Institute, Building 1052, Room 121, Frederick, Maryland, 21702-1201
Pages 659-665 | Published online: 23 Oct 2006

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Khisal A. Alvi, Songjie Wang & Guillermo Tous. (2008) New and Rapid Ultra‐Performance Liquid Chromatography Assay of Paclitaxel. Journal of Liquid Chromatography & Related Technologies 31:7, pages 941-949.
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Haihong Sun, Xiunan Li, Guanghui Ma & Zhiguo Su. (2005) A Facile Two‐Column Chromatographic Process for Efficient Purification of Paclitaxel from Crude Extract. Journal of Liquid Chromatography & Related Technologies 28:4, pages 605-617.
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Young Kwang Park, Sung Taik Chung & Kyung Ho Row. (1999) PREPARATIVE CHROMATOGRAPHIC SEPARATION OF TAXOL FROM YEW TREES. Journal of Liquid Chromatography & Related Technologies 22:18, pages 2755-2761.
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Raymond E. B. Ketchum, Judy V. Luong & Donna M. Gibson. (1999) EFFICIENT EXTRACTION OF PACLITAXEL AND RELATED TAXOIDS FROM LEAF TISSUE OF TAXUS USING A POTABLE SOLVENT SYSTEM. Journal of Liquid Chromatography & Related Technologies 22:11, pages 1715-1732.
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R.E. B. Ketchum & D.M. Gibson. (1995) A Novel Method of Isolating Taxanes from Cell Suspension Cultures of Yew (Taxus Spp.). Journal of Liquid Chromatography 18:6, pages 1093-1111.
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M. T. Huizing, V. H. Sewberath Misser, R. C. Pieters, W. W. ten Bokkel Huinink, C. H. N. Veenhof, J. B. Vermorken, H. M. Pinedo & J. H. Beijnen. (1995) Taxanes: A New Class of Antitumor Agents. Cancer Investigation 13:4, pages 381-404.
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W.J. Kopycki, H.N. Elsohly & J.D. McChesney. (1994) HPLC Determination of Taxol and Related Compounds in Taxus Plant Extracts. Journal of Liquid Chromatography 17:12, pages 2569-2591.
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EnakshaR. M. Wickremesinhe & RichardN. Arteca. (1993) Methodology for the Identification and Purification of Taxol and Cephalomannine from Taxus Callus Cultures. Journal of Liquid Chromatography 16:15, pages 3263-3274.
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RaymondE. B. Ketchum & DonnaM. Gibson. (1993) Rapid Isocratic Reversed Phase HPLC of Taxanes on New Columns Developed Specifically for Taxol Analysis. Journal of Liquid Chromatography 16:12, pages 2519-2530.
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TrevorP. Castor & TheodoreA. Tyler. (1993) Determination of Taxol in Taxus Media Needles in the Presence of Interfering Components. Journal of Liquid Chromatography 16:3, pages 723-731.
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R. Vanhaelen-Fastre, B. Diallo, M. Jaziri, M-L. Faes, J. Homes & M. Vanhaelen. (1992) High-Speed Countercurrent Chromatography Separation of Taxol and Related Diterpenoids from Taxus Baccata . Journal of Liquid Chromatography 15:4, pages 697-706.
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Articles from other publishers (54)

Asmaa Gamal, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Ashraf S. A. El-Sayed & Maher M. El-Domiaty. (2024) Production and bioprocessing of Taxol from Aspergillus niger, an endophyte of Encephalartos whitelockii, with a plausible biosynthetic stability: antiproliferative activity and cell cycle analysis. Microbial Cell Factories 23:1.
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El-Sayed R. El-Sayed, Ashraf S. Ahmed, Ismail A. Hassan, Ahmed A. Ismaiel & Al-Zahraa A. Karam El-Din. (2020) Semi-continuous production of the anticancer drug taxol by Aspergillus fumigatus and Alternaria tenuissima immobilized in calcium alginate beads. Bioprocess and Biosystems Engineering 43:6, pages 997-1008.
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Mugesh Subramanian & Murugan Marudhamuthu. (2020) Hitherto Unknown Terpene Synthase Organization in Taxol-Producing Endophytic Bacteria Isolated from Marine Macroalgae. Current Microbiology 77:6, pages 918-923.
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E.R. El‐Sayed, A.S. Ahmed & O.E.A. Al‐Hagar. (2020) Agro‐industrial wastes for production of paclitaxel by irradiated Aspergillus fumigatus under solid‐state fermentation . Journal of Applied Microbiology 128:5, pages 1427-1439.
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Pradeep Kumar, Balwant Singh, Vikram Thakur, Abhishek Thakur, Nandita Thakur, Deepak Pandey & Duni Chand. (2019) Hyper-production of Taxol from Aspergillus fumigatus, an endophytic fungus isolated from Taxus sp. of the Northern Himalayan region. Biotechnology Reports, pages e00395.
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El-Sayed R. El-Sayed, Ashraf S. Ahmed, Ismail A. Hassan, Ahmed A. Ismaiel & Al-Zahraa A. Karam El-Din. (2019) Strain improvement and immobilization technique for enhanced production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima. Applied Microbiology and Biotechnology 103:21-22, pages 8923-8935.
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Ashraf S. A. El-Sayed, Nabil Z. Mohamed, Samia Safan, Marwa A. Yassin, Lamis Shaban, Ahmed A. Shindia, Gul Shad Ali & Mahmoud Z. Sitohy. (2019) Restoring the Taxol biosynthetic machinery of Aspergillus terreus by Podocarpus gracilior Pilger microbiome, with retrieving the ribosome biogenesis proteins of WD40 superfamily. Scientific Reports 9:1.
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El-Sayed R. El-Sayed, Ahmed A. Ismaiel, Ashraf S. Ahmed, Ismail A. Hassan & Al-Zahraa A. Karam El-Din. (2019) Bioprocess optimization using response surface methodology for production of the anticancer drug paclitaxel by Aspergillus fumigatus and Alternaria tenuissima: Enhanced production by ultraviolet and gamma irradiation. Biocatalysis and Agricultural Biotechnology 18, pages 100996.
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Ashraf S.A. El-Sayed, Dalia M.I. Ali, Marwa A. Yassin, Rawia A. Zayed & Gul Shad Ali. (2019) Sterol inhibitor “Fluconazole” enhance the Taxol yield and molecular expression of its encoding genes cluster from Aspergillus flavipes. Process Biochemistry 76, pages 55-67.
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Ashraf S.A. El-Sayed, Samia Safan, Nabil Z. Mohamed, Lamis Shaban, Gul Shad Ali & Mahmoud Z. Sitohy. (2018) Induction of Taxol biosynthesis by Aspergillus terreus, endophyte of Podocarpus gracilior Pilger, upon intimate interaction with the plant endogenous microbes. Process Biochemistry 71, pages 31-40.
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Sibel Bay&#;l Oguzkan, Bora Karagul, Ayse Uzun, Ozen Ozensoy Guler & Halil Ibrahim Ugras. (2017) Pre-purification of an Anticancer Drug (Paclitaxel) Obtained from Nut Husks. International Journal of Pharmacology 14:1, pages 76-82.
Crossref
Ahmed A. Ismaiel, Ashraf S. Ahmed, Ismail A. Hassan, El-Sayed R. El-Sayed & Al-Zahraa A. Karam El-Din. (2017) Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima. Applied Microbiology and Biotechnology 101:14, pages 5831-5846.
Crossref
Supunnika Somjaipeng, Angel Medina, Hanna Kwaśna, Jose Ordaz Ortiz & Naresh Magan. (2015) Isolation, identification, and ecology of growth and taxol production by an endophytic strain of Paraconiothyrium variabile from English yew trees (Taxus baccata). Fungal Biology 119:11, pages 1022-1031.
Crossref
Hojjat Sadeghi-aliabadi & Afsaneh Yegdaneh. 2013. Natural Products. Natural Products 3159 3171 .
M. A. Cremasco, B. J. Hritzko & N. -H. Linda Wang. (2009) Experimental purification of paclitaxel from a complex mixture of taxanes using a simulated moving bed. Brazilian Journal of Chemical Engineering 26:1, pages 207-218.
Crossref
Rangarajulu Senthil Kumaran, Johnpaul Muthumary, Eun-Ki Kim & Byung-Ki Hur. (2009) Production of taxol from Phyllosticta dioscoreae, a leaf spot fungus isolated from Hibiscus rosa-sinensis. Biotechnology and Bioprocess Engineering 14:1, pages 76-83.
Crossref
Gary A. Strobel, Berk Knighton, Katreena Kluck, Yuhao Ren, Tom Livinghouse, Meghan Griffin, Daniel Spakowicz & Joe Sears. (2008) The production of myco-diesel hydrocarbons and their derivatives by the endophytic fungus Gliocladium roseum (NRRL 50072). Microbiology 154:11, pages 3319-3328.
Crossref
B. V. S. K. Chakravarthi, Prasanta Das, Kalpana Surendranath, Anjali A. Karande & Chelliah Jayabaskaran. (2008) Production of paclitaxel by Fusarium solani isolated from Taxus celebica. Journal of Biosciences 33:2, pages 259-267.
Crossref
Sun Im Jeon, Sungyong Mun & Jin-Hyun Kim. (2006) Optimal temperature control in fractional precipitation for paclitaxel pre-purification. Process Biochemistry 41:2, pages 276-280.
Crossref
Boris Vaisman, Ariella Shikanov & Abraham J. Domb. (2005) Normal phase high performance liquid chromatography for determination of paclitaxel incorporated in a lipophilic polymer matrix. Journal of Chromatography A 1064:1, pages 85-95.
Crossref
Sang-Hyun Pyo, Heung-Bok Park, Bong-Kyu Song, Byung-Hee Han & Jin-Hyun Kim. (2004) A large-scale purification of paclitaxel from cell cultures of Taxus chinensis. Process Biochemistry 39:12, pages 1985-1991.
Crossref
J.H Kim. (2004) Prepurification of paclitaxel by micelle and precipitation. Process Biochemistry 39:11, pages 1567-1571.
Crossref
James K. Harper, Atta M. Arif, Eugene J. Ford, Gary A. Strobel, John A. PorcoJr.Jr., David P. Tomer, Kim L. Oneill, Elizabeth M. Heider & David M. Grant. (2003) Pestacin: a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities. Tetrahedron 59:14, pages 2471-2476.
Crossref
Gary Strobel, Eugene Ford, Jeerepun Worapong, James K. Harper, Atta M. Arif, David M. Grant, Peter C.W. Fung & Raymond Ming Wah Chau. (2002) Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities. Phytochemistry 60:2, pages 179-183.
Crossref
J.H. Kim, I.S. Kang, H.K. Choi, S.S. Hong & H.S. Lee. (2002) A novel prepurification for paclitaxel from plant cell cultures. Process Biochemistry 37:7, pages 679-682.
Crossref
Jia Yao Li & Gary A. Strobel. (2001) Jesterone and hydroxy-jesterone antioomycete cyclohexenone epoxides from the endophytic fungus Pestalotiopsis jesteri. Phytochemistry 57:2, pages 261-265.
Crossref
Keith J. Duff. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
Young Kwang Park, Kyung Ho Row & Sung Taik Chung. (2000) Adsorption characteristics and separation of taxol from yew tree by NP-HPLC. Separation and Purification Technology 19:1-2, pages 27-37.
Crossref
D.-J. Wu, Z. Ma & N.-H.L. Wang. (1999) Optimization of throughput and desorbent consumption in simulated moving-bed chromatography for paclitaxel purification. Journal of Chromatography A 855:1, pages 71-89.
Crossref
Stan R Svojanovsky, Kamal L Egodage, Jun Wu, Milan Slavik & George S Wilson. (1999) High sensitivity ELISA determination of taxol in various human biological fluids. Journal of Pharmaceutical and Biomedical Analysis 20:3, pages 549-555.
Crossref
Young Kwang Park, Sung Taik Chung & Kyung Ho Row. (1999) A simple method to determine the adsorption isotherm of taxol from a yew tree. Korean Journal of Chemical Engineering 16:3, pages 388-391.
Crossref
Xuefeng Yang, Kailu Liu & Man Xie. (1998) Purification of taxol by industrial preparative liquid chromatography. Journal of Chromatography A 813:1, pages 201-204.
Crossref
C. Bicamumpaka & M. Pagé. (1998) Development of a fluorescence polarization immunoassay (FPIA) for the quantitative determination of paclitaxel. Journal of Immunological Methods 212:1, pages 1-7.
Crossref
K. Hostettmann, A. Marston & M. HostettmannK. Hostettmann, A. Marston & M. Hostettmann. 1998. Preparative Chromatography Techniques. Preparative Chromatography Techniques 50 127 .
K. Hostettmann, A. Marston & M. HostettmannK. Hostettmann, A. Marston & M. Hostettmann. 1998. Preparative Chromatography Techniques. Preparative Chromatography Techniques 3 14 .
Gary A Strobel, Richard Torczynski & Arthur Bollon. (1997) Acremonium sp.—a leucinostatin A producing endophyte of European yew (Taxus baccata). Plant Science 128:1, pages 97-108.
Crossref
Jinping Liu, Kevin J Volk, Michelle J Mata, Edward H Kerns & Mike S Lee. (1997) Miniaturized HPLC and ionspray mass spectrometry applied to the analysis of Paclitaxel and taxanes. Journal of Pharmaceutical and Biomedical Analysis 15:11, pages 1729-1739.
Crossref
D.‐J. Wu, Z. Ma, B. W. Au & N.‐H. L. Wang. (2004) Recovery and purification of paclitaxel using low‐pressure liquid chromatography. AIChE Journal 43:1, pages 232-242.
Crossref
GA Strobel, WM Hess, E. Ford, RS Sidhu & X Yang. (1996) Taxol from fungal endophytes and the issue of biodiversity. Journal of Industrial Microbiology & Biotechnology 17:5-6, pages 417-423.
Crossref
Mondher Jaziri, Abdesslam Zhiri, Yan-Wen Guo, Jean-Pierre Dupont, Koichiro Shimomura, Hiroki Hamada, Maurice Vanhaelen & Jacques Homès. (1996) Taxus sp. cell, tissue and organ cultures as alternative sources for taxoids production: a literature survey. Plant Cell, Tissue and Organ Culture 46:1, pages 59-75.
Crossref
Veronika Németh-Kiss, Esther Forgács, Tibor Cserháti & Gábor Schmidt. (1996) Taxol content of various Taxus species in Hungary. Journal of Pharmaceutical and Biomedical Analysis 14:8-10, pages 997-1001.
Crossref
Jeff T. Beckvermit, Dominick J. Anziano & Christopher K. Murray. (1996) An Improved Method for Separating Paclitaxel and Cephalomannine Using Ozone and Girard Reagents. The Journal of Organic Chemistry 61:25, pages 9038-9040.
Crossref
Hassan Y. Aboul-Enein & Vince Serignese. (1996) Liquid chromatographic determination of taxol and related derivatives using a new polyfluorinated reversed-phase column. Analytica Chimica Acta 319:1-2, pages 187-190.
Crossref
Dauh-Rurng Wu, Klaus Lohse & Hellen C. Greenblatt. (1995) Preparative separation of taxol in normal- and reversed-phase operations. Journal of Chromatography A 702:1-2, pages 233-241.
Crossref
King C. Chan, A. Belinda Alvarado, Mary T. McGuire, Gary M. Muschik, Haleem J. Issaq & Kenneth M. Snader. (1994) High-performance liquid chromatography and micellar electrokinetic chromatography of taxol and related taxanes from bark and needle extracts of Taxus species. Journal of Chromatography B: Biomedical Sciences and Applications 657:2, pages 301-306.
Crossref
Gary Strobel, Andrea Stierle & W.M. Hess. (1994) The stimulation of taxol production in Taxus brevifolia by various growth retardants. Plant Science 101:2, pages 115-124.
Crossref
King C. Chan, Gary M. Muschik, Haleem J. Issaq & Kenneth M. Snader. (2005) Separation of taxol and related compounds by micellar electrokinetic chromatography. Journal of High Resolution Chromatography 17:1, pages 51-52.
Crossref
P. K. S. Blay, P. Thibault, N. Thiberge, B. Kiecken, A. Lebrun & C. Mercure. (2005) Analysis of taxol and related taxanes from taxus canadensis using liquid chromatography combined with mass spectrometry or tandem mass spectrometry . Rapid Communications in Mass Spectrometry 7:7, pages 626-634.
Crossref
Francis Bitsch, Wenwen Ma, Fraser Macdonald, Matthew Nieder & Cedric H.L. Shackleton. (1993) Analysis of taxol and related diterpenoids from cell cultures by liquid chromatography—electrospray mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 615:2, pages 273-280.
Crossref
Andrea StierleGary StrobelDonald Stierle. (1993) Taxol and Taxane Production by Taxomyces andreanae , an Endophytic Fungus of Pacific Yew . Science 260:5105, pages 214-216.
Crossref
Gary A. Strobel, Andrea Stierle & W.M. Hess. (1993) Taxol formation in yew — Taxus. Plant Science 92:1, pages 1-12.
Crossref
Paul G. Grothaus, T.J.G. Raybould, Gary S. Bignami, Carolyn B. Lazo & Jilanne B. Brynes. (1993) An enzyme immunoassay for the determination of taxol and taxanes in Taxus sp. tissues and human plasma. Journal of Immunological Methods 158:1, pages 5-15.
Crossref
Gary A. Strobel, Andrea Stierle & Frederik J.G.M. van Kuijk. (1992) Factors influencing the in vitro production of radiolabeled taxol by Pacific yew, Taxus brevifolia. Plant Science 84:1, pages 65-74.
Crossref
David G.I. Kingston. (1991) The chemistry of taxol. Pharmacology & Therapeutics 52:1, pages 1-34.
Crossref

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