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GENERAL PAPER

A Rapid Microscale Method for the Determination of Partition Coefficients by HPLC

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Pages 3365-3386 | Published online: 23 Oct 2006

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F. Péhourcq, J. Thomas & C. Jarry. (2000) A MICROSCALE HPLC METHOD FOR THE EVALUATION OF OCTANOL-WATER PARTITION COEFFICIENTS IN A SERIES OF NEW 2-AMINO-2-OXAZOLINES. Journal of Liquid Chromatography & Related Technologies 23:3, pages 443-453.
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Harry Ford$suffix/text()$suffix/text(), JohnS. Driscoll, Maqbool Siddiqui, JamesA. Kelley, Hioraki Mitsuya, Takuma Shirasaka, DavidG. Johns & VictorE. Marquez. (1994) Chemistry and Anti-HIV Activity of 2′-β-Fluoro-2′,3′-dideoxyguanosine. Nucleosides and Nucleotides 13:1-3, pages 213-234.
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Articles from other publishers (20)

Yongfen Ma, Xiaowei Chen, Huma Javeria & Zhenxia Du. (2023) High-throughput screening of LogD by using a sample pooling approach based on the traditional shake flask method. Journal of Chromatography B 1227, pages 123804.
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Asmita Magotra, Anjna Sharma, Samsher Singh, Probir Kumar Ojha, Sunil Kumar, Naveen Bokolia, Priya Wazir, Shweta Sharma, Inshad Ali Khan, Parvinder Pal Singh, Ram A. Vishwakarma, Gurdarshan Singh & Utpal Nandi. (2018) Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silico – in-vitro – in-vivo approach. Pulmonary Pharmacology & Therapeutics 48, pages 151-160.
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Ankit Saneja, Debasis Nayak, M. Srinivas, Amit Kumar, Vaibhav Khare, Archana Katoch, Anindya Goswami, Ram A. Vishwakarma, Sanghapal D. Sawant & Prem N. Gupta. (2017) Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells. European Journal of Pharmaceutical Sciences 97, pages 79-91.
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Ying Wei (Ivan) Low, Francesca Blasco & Prakash Vachaspati. (2016) Optimised method to estimate octanol water distribution coefficient (logD) in a high throughput format. European Journal of Pharmaceutical Sciences 92, pages 110-116.
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Ravindra Dhar Dubey, Ankit Saneja, Arem Qayum, Amarinder Singh, Girish Mahajan, Gousia Chashoo, Amit Kumar, Samar S. Andotra, Shashank K. Singh, Gurdarshan Singh, Surinder Koul, Dilip M. Mondhe & Prem N. Gupta. (2016) PLGA nanoparticles augmented the anticancer potential of pentacyclic triterpenediol in vivo in mice. RSC Advances 6:78, pages 74586-74597.
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Marina Shalaeva, Giulia Caron, Yuriy A. Abramov, Thomas N. O’Connell, Mark S. Plummer, Geeta Yalamanchi, Kathleen A. Farley, Gilles H. Goetz, Laurence Philippe & Michael J. Shapiro. (2013) Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool. Journal of Medicinal Chemistry 56:12, pages 4870-4879.
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Chenyu WeiAndrew Pohorille. (2013) Permeation of Aldopentoses and Nucleosides Through Fatty Acid and Phospholipid Membranes: Implications to the Origins of Life. Astrobiology 13:2, pages 177-188.
Crossref
Maria Henczi, Jeno Nagy & Donald F Weaver. (1995) Determination of Octanol-water Partition Coefficients by an HPLC Method for Anticonvulsant Structure-activity Studies. Journal of Pharmacy and Pharmacology 47:4, pages 345-347.
Crossref
Yun W. Alelyunas, Luciana Pelosi-Kilby, Pascal Turcotte, Mary-Britt Kary & Russell C. Spreen. (2010) A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection. Journal of Chromatography A 1217:12, pages 1950-1955.
Crossref
Isabelle Lefebvre, Thierry Beltran, Suzanne Peyrottes & Christian Périgaud. (2009) Decomposition of 3′-azido-2′,3′-dideoxythymidine 5′-monophosphate (AZTMP) prodrugs in biological media studied by on-line solid-phase extraction coupled to liquid chromatography mass spectrometry. Biomedical Chromatography 23:11, pages 1160-1168.
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Rajesh Rathore, Jay Prakash Jain, Amit Srivastava, S.M. Jachak & Neeraj Kumar. (2008) Simultaneous determination of hydrazinocurcumin and phenol red in samples from rat intestinal permeability studies: HPLC method development and validation. Journal of Pharmaceutical and Biomedical Analysis 46:2, pages 374-380.
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Yining Zhao, Janan Jona, David T. Chow, Haojing Rong, David Semin, Xiaoyang Xia, Roger Zanon, Chris Spancake & Ed Maliski. (2002) High-throughput logP measurement using parallel liquid chromatography/ultraviolet/mass spectrometry and sample-pooling. Rapid Communications in Mass Spectrometry 16:16, pages 1548-1555.
Crossref
Thierry Beltran, David Egron, Alain Pompon, Isabelle Lefebvre, Christian Périgaud, Gilles Gosselin, Anne-Marie Aubertin & Jean-Louis Imbach. (2001) Rational design of a new series of pronucleotide. Bioorganic & Medicinal Chemistry Letters 11:13, pages 1775-1777.
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Heping Zhang, Harry FordJr.Jr., Jeri S. Roth & James A. Kelley. (2001) Evaluation of a fluorogenic derivatization method for the reversed-phase HPLC analysis of 2?-?-fluoro-2?,3?-dideoxyadenosine, a new anti-AIDS drug. Journal of Pharmaceutical and Biomedical Analysis 25:2, pages 285-297.
Crossref
M. Shafiee, S. Deferme, A.‐L. Villard, D. Egron, G. Gosselin, J.‐L. Imbach, T. Lioux, A. Pompon, S. Varray, A.‐M. Aubertin, G.Van Den Mooter, R. Kinget, C. Périgaud & P. Augustijns. (2001) New bis(SATE) prodrug of AZT 5′‐monophosphate: In vitro anti‐HIV activity, stability, and potential oral absorption. Journal of Pharmaceutical Sciences 90:4, pages 448-463.
Crossref
Klára Valkó. 2000. Separation Methods in Drug Synthesis and Purification. Separation Methods in Drug Synthesis and Purification 535 583 .
KK Manouilov, Z-S Xu, LS Manouilova, FD Boudinot, RF Schinazi & CK Chu. (2016) Lymphatic Targeting of Anti-Human Immunodeficiency Virus Nucleosides: Pharmacokinetics of G′-Deoxy-2′,3′-Didehydrothymidine after Intravenous and Oral Administration of Dipalmitoylphosphatidyl Prodrug to Mice. Antiviral Chemistry and Chemotherapy 8:5, pages 409-415.
Crossref
H. van de Waterbeemd & R. Mannhold. 1996. Lipophilicity in Drug Action and Toxicology. Lipophilicity in Drug Action and Toxicology 401 418 .
Marc C. Nicklaus, Harry FordJr.Jr., Lajos Hegedũs, George W. A. Milne & James A. Kelley. (2006) Comparative Molecular Field Analysis of Hydrophobicity Descriptors of Cytosine Nucleosides. Quantitative Structure-Activity Relationships 14:4, pages 335-343.
Crossref
S KageyamaT MimotoY MurakawaM NomizuH FordJrJrT ShirasakaS GulnikJ EricksonK TakadaH Hayashi. (1993) In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine. Antimicrobial Agents and Chemotherapy 37:4, pages 810-817.
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