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Orignal Articles

Suppression of Implanted MDA-MB 231 Human Breast Cancer Growth in Nude Mice by Dietary Walnut

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Pages 666-674 | Received 04 Sep 2007, Accepted 02 Jan 2008, Published online: 12 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Trang H.D. Nguyen & Danh C. Vu. (2023) A Review on Phytochemical Composition and Potential Health-promoting Properties of Walnuts. Food Reviews International 39:1, pages 397-423.
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Ho-Jae Lee, Young-Min Han, Jeong Min An, Eun A. Kang, Yong Jin Park, Ji-Young Cha & Ki Baik Hahm. (2018) Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives. Expert Review of Anticancer Therapy 18:12, pages 1189-1203.
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David Hayes, Michael J. Angove, Joe Tucci & Christina Dennis. (2016) Walnuts (Juglans regia) Chemical Composition and Research in Human Health. Critical Reviews in Food Science and Nutrition 56:8, pages 1231-1241.
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Vy Le, Debora Esposito, Mary H. Grace, Danny Ha, Anh Pham, Anthony Bortolazzo, Zackery Bevens, John Kim, Roy Okuda, Slavko Komarnytsky, Mary Ann Lila & Joseph Brandon White. (2014) Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells. Nutrition and Cancer 66:8, pages 1304-1314.
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Russel J. Reiter, Dun-Xian Tan, Lucien C. Manchester, Ahmet Korkmaz, Lorena Fuentes-Broto, W. Elaine Hardman, Sergio A. Rosales-Corral & Wenbo Qi. (2013) A Walnut-Enriched Diet Reduces the Growth of LNCaP Human Prostate Cancer Xenografts in Nude Mice. Cancer Investigation 31:6, pages 365-373.
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Johannes F. Fahrmann, Oscar F. Ballester, Gabriela Ballester, Theodore R. Witte, Alexander J. Salazar, Benjamin Kordusky, Kelsey G. Cowen, Gabriela Ion, Donald A. Primerano, Goran Boskovic, James Denvir & W. Elaine Hardman. (2013) Inhibition of Nuclear Factor Kappa B activation in Early-Stage Chronic Lymphocytic Leukemia by Omega-3 Fatty Acids. Cancer Investigation 31:1, pages 24-38.
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Mona Salimi, Ahmad Majd, Zahra Sepahdar, Kayhan Azadmanesh, Saeed Irian, Mohammad Hassan Ardestaniyan, Mohammad Hossein Hedayati & Nooshin Rastkari. (2012) Cytotoxicity effects of various Juglans regia (walnut) leaf extracts in human cancer cell lines. Pharmaceutical Biology 50:11, pages 1416-1422.
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John P. Vanden Heuvel, BenjaminJ. Belda, DanB. Hannon, PennyM. Kris-Etherton, JessicaA. Grieger, Jun Zhang & JerryT. Thompson. (2012) Mechanistic Examination of Walnuts in Prevention of Breast Cancer. Nutrition and Cancer 64:7, pages 1078-1086.
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W. Elaine Hardman, Gabriela Ion, JulianaA. Akinsete & TheodoreR. Witte. (2011) Dietary Walnut Suppressed Mammary Gland Tumorigenesis in the C(3)1 TAg Mouse. Nutrition and Cancer 63:6, pages 960-970.
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Articles from other publishers (53)

Nuoxi Fan, Jennifer L. Fusco & Daniel W. Rosenberg. (2023) Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome. Antioxidants 12:5, pages 982.
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Bradley W. Bolling, Dagfinn Aune, Hwayoung Noh, Kristina S. Petersen & Heinz Freisling. (2023) Dried Fruits, Nuts, and Cancer Risk and Survival: A Review of the Evidence and Future Research Directions. Nutrients 15:6, pages 1443.
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Lauri O. Byerley, Hsiao-Man Chang, Brittany Lorenzen, Jessie Guidry & W. Elaine Hardman. (2022) Impact of dietary walnuts, a nutraceutical option, on circulating markers of metabolic dysregulation in a rodent cachectic tumor model. Biomedicine & Pharmacotherapy 155, pages 113728.
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Armando Manuel Martín OrtegaLeydi Maribel Carrillo CocomMaira Rubi Segura Campos. (2022) Salvia hispanica L. Seed Oil: Effect on Cell Viability in Colon Cancer Line Caco2 and Breast Cancer Line MCF7 . Journal of Medicinal Food 25:5, pages 529-533.
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Philippe T. Georgel & Philippe Georgel. (2021) Where Epigenetics Meets Food Intake: Their Interaction in the Development/Severity of Gout and Therapeutic Perspectives. Frontiers in Immunology 12.
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Pei Yee Tan & Kim Tiu Teng. (2021) Role of dietary fat on obesity-related postmenopausal breast cancer: insights from mouse models and methodological considerations. Breast Cancer 28:3, pages 556-571.
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Akula Ramakrishna & Atanu Bhattacharjee. 2021. Analytical Methods in the Determination of Bioactive Compounds and Elements in Food. Analytical Methods in the Determination of Bioactive Compounds and Elements in Food 227 241 .
Khanh-Van Ho, Anuradha Roy, Sarah Foote, Phuc H. Vo, Namrita Lall & Chung-Ho Lin. (2020) Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (Juglans nigra) Using a High-Throughput Screening Approach. Molecules 25:19, pages 4516.
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Yanfei Chen, Masako Nakanishi, Eddy J. Bautista, Veneta Qendro, Erica Sodergren, Daniel W. Rosenberg & George M. Weinstock. (2020) Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype–like Cluster. Cancer Prevention Research 13:1, pages 15-24.
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Zarghouna Chudhary, Rasheed Ahmad Khera, Muhammad Asif Hanif, Muhammad Adnan Ayub & Lamia Hamrouni. 2020. Medicinal Plants of South Asia. Medicinal Plants of South Asia 671 684 .
Jorge L. Gutierrez-Pajares, Celine Ben Hassen, Camille Oger, Jean-Marie Galano, Thierry Durand & Philippe G. Frank. (2019) Oxidized Products of α-Linolenic Acid Negatively Regulate Cellular Survival and Motility of Breast Cancer Cells. Biomolecules 10:1, pages 50.
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Rashmi Deshpande, Prerna Raina, Kavita Shinde, Prakash Mansara, Manjiri Karandikar & Ruchika Kaul-Ghanekar. (2019) Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer. Prostaglandins & Other Lipid Mediators 143, pages 106332.
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Marius Emil Rusu, Ramona Simedrea, Ana-Maria Gheldiu, Andrei Mocan, Laurian Vlase, Daniela-Saveta Popa & Isabel C.F.R. Ferreira. (2019) Benefits of tree nut consumption on aging and age-related diseases: Mechanisms of actions. Trends in Food Science & Technology 88, pages 104-120.
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W. Elaine Hardman, Donald A. Primerano, Mary T. Legenza, James Morgan, Jun Fan & James Denvir. (2019) Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast cancer patients: a pilot clinical trial. Nutrition Research 66, pages 82-94.
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Jina Choi, Phil-Kyung Shin, Yuri Kim, Chang Pyo Hong & Sang-Woon Choi. (2018) Metabolic influence of walnut phenolic extract on mitochondria in a colon cancer stem cell model. European Journal of Nutrition 58:4, pages 1635-1645.
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Masako Nakanishi, Alyssa Matz, Cory Klemashevich & Daniel W. Rosenberg. (2019) Dietary Walnut Supplementation Alters Mucosal Metabolite Profiles During DSS-Induced Colonic Ulceration. Nutrients 11:5, pages 1118.
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Saime Batirel, Ayse Mine Yilmaz, Ali Sahin, Nikolaos Perakakis, Nesrin Kartal Ozer & Christos S. Mantzoros. (2018) Antitumor and antimetastatic effects of walnut oil in esophageal adenocarcinoma cells. Clinical Nutrition 37:6, pages 2166-2171.
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Elena Catanzaro, Giulia Greco, Lucia Potenza, Cinzia Calcabrini & Carmela Fimognari. (2018) Natural Products to Fight Cancer: A Focus on Juglans regia. Toxins 10:11, pages 469.
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Mirazkar D. Pandareesh, Ved Chauhan & Abha Chauhan. (2018) Walnut Supplementation in the Diet Reduces Oxidative Damage and Improves Antioxidant Status in Transgenic Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's Disease 64:4, pages 1295-1305.
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Marius Emil Rusu, Ana-Maria Gheldiu, Andrei Mocan, Laurian Vlase & Daniela-Saveta Popa. (2018) Anti-aging potential of tree nuts with a focus on the phytochemical composition, molecular mechanisms and thermal stability of major bioactive compounds. Food & Function 9:5, pages 2554-2575.
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Lauri O. Byerley, Derrick Samuelson, Eugene BlanchardIVIV, Meng Luo, Brittany N. Lorenzen, Shelia Banks, Monica A. Ponder, David A. Welsh & Christopher M. Taylor. (2017) Changes in the gut microbial communities following addition of walnuts to the diet. The Journal of Nutritional Biochemistry 48, pages 94-102.
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Ying Lv, Kaihua Wei, Xiaoguang Meng, Yajuan Huang, Tuo Zhang & Zhen Li. (2017) Separation and identification of iron-chelating peptides from defatted walnut flake by nanoLC-ESI–MS/MS and de novo sequencing. Process Biochemistry 59, pages 223-228.
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Ryszard Amarowicz, Yi Gong & Ronald B. Pegg. 2016. Wild Plants, Mushrooms and Nuts. Wild Plants, Mushrooms and Nuts 377 409 .
Gihyun Lee & Sun Kim. (2016) Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy. Molecules 21:9, pages 1252.
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Nisha Panth, Keshav Raj Paudel & Rajendra Karki. (2016) Phytochemical profile and biological activity of Juglans regia. Journal of Integrative Medicine 14:5, pages 359-373.
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Masako Nakanishi, Yanfei Chen, Veneta Qendro, Shingo Miyamoto, Erica Weinstock, George M. Weinstock & Daniel W. Rosenberg. (2016) Effects of Walnut Consumption on Colon Carcinogenesis and Microbial Community Structure. Cancer Prevention Research 9:8, pages 692-703.
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Jisoo Lee, Yoo-Sun Kim, JaeHwan Lee, Seung Heo, Kook Lee, Sang-Woon Choi & Yuri Kim. (2016) Walnut Phenolic Extract and Its Bioactive Compounds Suppress Colon Cancer Cell Growth by Regulating Colon Cancer Stemness. Nutrients 8:7, pages 439.
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Dongdong Bi, Yicheng Zhao, Rui Jiang, Yan Wang, Yuxin Tian, Xiaoyi Chen, Shaojuan Bai & Gaimei She. (2016) Phytochemistry, Bioactivity and Potential Impact on Health of Juglans: the Original Plant of Walnut . Natural Product Communications 11:6, pages 1934578X1601100.
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Julie K. Mason-Ennis, Lauren P. LeMay-Nedjelski, Ashleigh K.A. Wiggins & Lilian U. Thompson. (2016) Exploration of mechanisms of α-linolenic acid in reducing the growth of oestrogen receptor positive breast cancer cells (MCF-7). Journal of Functional Foods 24, pages 513-519.
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Michael A. Tsoukas, Byung-Joon Ko, Theodore R. Witte, Fadime Dincer, W. Elaine Hardman & Christos S. Mantzoros. (2015) Dietary walnut suppression of colorectal cancer in mice: Mediation by miRNA patterns and fatty acid incorporation. The Journal of Nutritional Biochemistry 26:7, pages 776-783.
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Musthafa Mohamed Essa, Selvaraju Subash, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Samir Al-Adawi, Gilles J. Guillemin & Arokiasamy Justin Thenmozhi. (2015) Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson’s Disease. Neurochemical Research 40:6, pages 1283-1293.
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Lucia Laubertová, Katarína Koňariková, Helena Gbelcová, Zdeňka Ďuračková & Ingrid Žitňanová. (2014) Effect of walnut oil on hyperglycemia-induced oxidative stress and pro-inflammatory cytokines production. European Journal of Nutrition 54:2, pages 291-299.
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Hyunsook KimWallace YokoyamaPaul Andrew Davis. (2014) TRAMP Prostate Tumor Growth Is Slowed by Walnut Diets Through Altered IGF-1 Levels, Energy Pathways, and Cholesterol Metabolism. Journal of Medicinal Food 17:12, pages 1281-1286.
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Beate Pfundstein, Roswitha Haubner, Gerd Würtele, Nicole Gehres, Cornelia M. Ulrich & Robert W. Owen. (2014) Pilot Walnut Intervention Study of Urolithin Bioavailability in Human Volunteers. Journal of Agricultural and Food Chemistry 62:42, pages 10264-10273.
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W. Elaine Hardman. (2014) Walnuts Have Potential for Cancer Prevention and Treatment in Mice. The Journal of Nutrition 144:4, pages 555S-560S.
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Cheryl D. Toner. (2014) Communicating clinical research to reduce cancer risk through diet: Walnuts as a case example. Nutrition Research and Practice 8:4, pages 347.
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W. Elaine Hardman. (2014) Diet components can suppress inflammation and reduce cancer risk. Nutrition Research and Practice 8:3, pages 233.
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Flavia De Carlo, Theodore R. Witte, W. Elaine Hardman & Pier Paolo Claudio. (2013) Omega-3 Eicosapentaenoic Acid Decreases CD133 Colon Cancer Stem-Like Cell Marker Expression While Increasing Sensitivity to Chemotherapy. PLoS ONE 8:7, pages e69760.
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D.L. McNeil. 2013. Improving the Safety and Quality of Nuts. Improving the Safety and Quality of Nuts 245 273 .
Shibu M. Poulose & Barbara Shukitt-Hale. 2013. Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits. Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits 171 187 .
Michael R. Moore & Rebecca A. King. (2012) Effects of Omega-3 Fatty Acids on Progestin Stimulation of Invasive Properties in Breast Cancer. Hormones and Cancer 3:5-6, pages 205-217.
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Paul A. Davis, Vihas T. Vasu, Kishorchandra Gohil, Hyunsook Kim, Imran H. Khan, Carroll E. Cross & Wallace Yokoyama. (2012) A high-fat diet containing whole walnuts ( Juglans regia ) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model . British Journal of Nutrition 108:10, pages 1764-1772.
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Akula Ramakrishna, Parvatam Giridhar, Kadimi Udaya Sankar & Gokare Aswathanarayana Ravishankar. (2013) Melatonin and serotonin profiles in beans of Coffea species . Journal of Pineal Research 52:4, pages 470-476.
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Ali A. Alshatwi, Tarique N. Hasan, Gowhar Shafi, Naveed Ahmed Syed, Abdullah H. Al-Assaf, Mohammed S. Alamri & Abdrohman S. Al-Khalifa. (2012) Validation of the Antiproliferative Effects of Organic Extracts from the Green Husk of Juglans regia L. on PC-3 Human Prostate Cancer Cells by Assessment of Apoptosis-Related Genes . Evidence-Based Complementary and Alternative Medicine 2012, pages 1-8.
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Jutta M. Nagel, Mary Brinkoetter, Faidon Magkos, Xiaowen Liu, John P. Chamberland, Sunali Shah, Jinrong Zhou, George Blackburn & Christos S. Mantzoros. (2012) Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition 28:1, pages 67-75.
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Abha Chauhan & Ved Chauhan. 2012. Brain Aging and Therapeutic Interventions. Brain Aging and Therapeutic Interventions 239 252 .
Balu Muthaiyah, Musthafa M. Essa, Ved Chauhan & Abha Chauhan. (2011) Protective Effects of Walnut Extract Against Amyloid Beta Peptide-Induced Cell Death and Oxidative Stress in PC12 Cells. Neurochemical Research 36:11, pages 2096-2103.
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Diana Labuckas, Damián Maestri & Alicia Lamarque. (2011) Lipid and protein stability of partially defatted walnut flour ( Juglans regia L.) during storage . International Journal of Food Science & Technology 46:7, pages 1388-1397.
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Melinda E. Varney, James T. Buchanan, Yulia Dementieva, W. Elaine Hardman & Vincent E. Sollars. (2010) A High Omega‐3 Fatty Acid Diet has Different Effects on Early and Late Stage Myeloid Progenitors. Lipids 46:1, pages 47-57.
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Theodore R Witte, Alexander J Salazar, Oscar F Ballester & W Elaine Hardman. (2010) RBC and WBC fatty acid composition following consumption of an omega 3 supplement: Lessons for future clinical trials. Lipids in Health and Disease 9:1.
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Emilio Ros. (2010) Health Benefits of Nut Consumption. Nutrients 2:7, pages 652-682.
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Márcia Carvalho, Pedro J. Ferreira, Vanda S. Mendes, Renata Silva, José A. Pereira, Carmen Jerónimo & Branca M. Silva. (2010) Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.. Food and Chemical Toxicology 48:1, pages 441-447.
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